Dr. Luis Caspeta Guadarrama
Ex-colaborador y/o ex-alumno
* Indica publicación con otra institución de adscripción
Total de publicaciones: 36
- Tipo
- Fecha
Revisión
1 - Perez-Morales,G., Merino,E., Cevallos,M.A., Gosset,G., Licona-Cassani,C., Caspeta,L., Martinez,A. (2026). Toward a systems metabolic engineering approach to improve thermotolerance of Escherichia coli.
Microbial Cell Factories,
25,
108.
Artículo
2 - Martinez,J.A., Bouchat,R., Gallet de St Aurin,T., Martinez,L.M., Caspeta,L., Telek,S., Zicler,A., Gosset,G., Delvigne,F. (2025). Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures.
Trends in Biotechnology,
43 (5),
1116-1139.
Artículo
3 - Molina-Vazquez,E.R., Caspeta,L., Gosset,G., Martinez,A. (2025). Tailoring Escherichia coli BL21 (DE3) for preferential xylose utilization via metabolic and regulatory engineering.
Applied Microbiology and Biotechnology,
109 (1),
54.
Artículo
4 - Perez-Morales,G., Martinez-Conde,K.V., Caspeta,L., Merino,E., Cevallos,M.A., Gosset,G., Martinez,A. (2025). Thermally adapted Escherichia coli keeps transcriptomic response during temperature upshift exposure.
Applied Microbiology and Biotechnology,
109 (1),
120.
Artículo
5 - Perez-Morales,G., Caspeta,L., Merino,E., Cevallos,M.A., Gosset,G., Martinez,A. (2024). Simultaneous saccharification and fermentation for D-lactic acid production using a metabolically engineered Escherichia coli adapted to high temperature.
Biotechnology for Biofuels and Bioproducts,
17 (1),
132.
Artículo
6 - Avila-Fernandez, A., Montiel,S., Rodriguez Alegria, M.E., Caspeta,L., Lopez-Munguia,A. (2023). Simultaneous enzyme production, Levan-type FOS synthesis and sugar by-products elimination using a recombinant Pichia pastoris strain expressing a levansucrase- endolevanase fusion enzyme.
Microbial Cell Factories,
22 (1),
18.
Artículo
7 - Salas-Navarrete,P.C., Rosas-Santiago,P., Suarez-Rodriguez,R., Martinez,A., Caspeta,L. (2023). Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature.
Applied Microbiology and Biotechnology,
107 (12),
4051-4068.
artículo
8 - Salas-Navarrete,P.C., Montees de Oca Miranda,A.I., Martinez,A., Caspeta,L. (2022). Evolutionary and reverse engineering to increase Saccharomyces cerevisiae tolerance to acetic acid, acidic pH, and high temperature.
Applied Microbiology and Biotechnology,
106 (1),
383-399.
Artículo
Artículo
10 - Caspeta,L., Kerkhoven,E.J., Martinez,A., Nielsen,J. (2021). The yeastGemMap: A process diagram to assist yeast systems-metabolic studies.
Biotechnology and Bioengineering,
118 (12),
4800-4814.
Artículo
11 - Bertrand,B., Trejo-Hernandez,M.R., Morales-Guzman,D., Caspeta,L., Suarez-Rodriguez R., Martinez-Morales,F. (2016). Functional expression, production, and biochemical characterization of a laccase using yeast surface display technology.
Fungal Biology,
120 (12),
1609-1622.
*
Artículo
12 - Caspeta,L., Chen,Y., Nielsen,J. (2016). Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C.
Scientific Reports,
6,
27003.
*
Artículo
13 - Caspeta,L., Nielsen,J. (2015). Thermotolerant Yeast Strains Adapted by Laboratory Evolution Show Trade-Off at Ancestral Temperatures and Preadaptation to Other Stresses.
MBio,
6 (4),
e00431.
*
Revisión
14 - Caspeta,L., Castillo,T., Nielsen,J. (2015). Modifying Yeast Tolerance to Inhibitory Conditions of Ethanol Production Processes.
Frontiers in Bioengineering and Biotechnology,
3,
184.
*
Artículo
15 - Caspeta,L., Chen,Y., Ghiaci,P., Feizi,A., Buskov,S., Hallstrom,B.M., Petranovic,D., Nielsen,J. (2014). Biofuels. Altered sterol composition renders yeast thermotolerant.
Science,
346 (6205),
75-78.
*
Carta
16 - Caspeta,L., Nielsen,J. (2013). Economic and environmental impacts of microbial biodiesel.
Nature Biotechnology,
31 (9),
789-793.
*
Artículo
17 - Caspeta,L., Lara,A.R., Perez,N.O., FLORES,N., Bolivar,F., Ramirez,O.T. (2013). Enhancing thermo-induced recombinant protein production in Escherichia coli by temperature oscillations and post-induction nutrient feeding strategies.
Journal of Biotechnology,
167 (1),
47-55.
Revisión
18 - Caspeta,L., Nielsen,J. (2013). Toward systems metabolic engineering of Aspergillus and Pichia species for the production of chemicals and biofuels.
Biotechnology Journal,
8 (5),
534-544.
*
Artículo
19 - Caspeta,L., Shoaie,S., Agren,R., Nookaew,I., Nielsen,J. (2012). Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials.
BMC Systems Biology,
6,
24.
*
Artículo
20 - Lara,A.R., Knabben,I., Regestein,L., Sassi,J., Caspeta,L., Ramirez,O.T., Buchs,J. (2011). Comparison of oxygen enriched air vs. pressure cultivations to increase oxygen transfer and to scale-up plasmid DNA production fermentations.
Engineering in Life Sciences,
11 (4),
382-386.
Artículo
21 - Soto,R., Caspeta,L., Barron,B., Gosset,G., Ramirez,O.T., Lara,A.R. (2011). High cell-density cultivation in batch mode for plasmid DNA production by a metabolically engineered E. coli strain with minimized overflow metabolism.
Biochemical Engineering Journal,
56 (3),
165-171.
Revisión
22 - Valdez-Cruz,N.A., Caspeta,L., Perez,N.O., Ramirez,O.T., Trujillo-Roldan,M.A. (2010). Production of recombinant proteins in E. coli by the heat inducible expression system based on the phage lambda pL and/or pR promoters.
Microbial Cell Factories,
9 (1),
18.
Artículo
23 - Caspeta,L., FLORES,N., Perez,N.O., Bolivar,F., Ramirez,O.T. (2009). The effect of heating rate on Escherichia coli metabolism, physiological stress, transcriptional response, and production of temperature-induced recombinant protein: a scale-down study.
Biotechnology and Bioengineering,
102 (2),
468-482.
Artículo
24 - Lara,A.R., Caspeta,L., Gosset,G., Bolivar,F., Ramirez,O.T. (2008). Utility of an Escherichia coli strain engineered in the substrate uptake system for improved culture performance at high glucose and cell concentrations: An alternative to fed-batch cultures.
Biotechnology and Bioengineering,
99 (4),
893-901.
Artículo
25 - Villarreal,M.L., Caspeta,L., Quintero-Ramirez,R. (2008). From the Mayan Highlands to the Bioreactors: In Vitro Tissue Culture of the Mexican Medicinal Plant Solanum chrysotrichum.
Electronic Journal of Integrative Biosciences,
3 (1),
20-28.
*
Artículo
26 - Caspeta,L., Quintero,R., Villarreal,M.L. (2005). Novel airlift reactor fitting for hairy root cultures: developmental and performance studies.
Biotechnology Progress,
21 (3),
735-740.
*
Artículo
27 - Caspeta,L., Nieto,I., Zamilpa,A., Alvarez,L., Quintero,R., Villarreal,M.L. (2005). Solanum chrysotrichum hairy root cultures: characterization, scale-up and production of five antifungal saponins for human use.
Planta Medica,
71 (11),
1084-1087.
*
Internacional
28 - Caspeta,L., Salas-Navarrete,P.C. (2019). Reduction of the Saccharomyces cerevisiae Genome: Challenges and Perspectives. Minimal Cells: Design, Construction, Biotechnological Applications.
117-139,
Cham: Springer International Publishing.
Internacional
29 - Caspeta, L., Castillo, T. (2017). Systems Metabolic Engineering of Saccharomyces cerevisiae for Production of Biochemicals from Biomass. Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources.
31-65,
Cham.
*
Preprint
30 - Martinez-Alvarez,J.A., Bouchat,R., Gallet de St Aurin,T., Martinez,L.M., Caspeta,L., Telek,S., Zicler,A., Gosset,G., Delvigne,F. (2024). Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures.
bioRxiv,
Preprint posted May 14.
Preprint
31 - Caspeta,L., Salas-Navarrete,P.C., Rosas-Santiago,P., Suarez-Rodriguez,R., Martinez,A. (2023). Adaptive responses of evolved Saccharomyces cerevisiae strains tolerant to acidic pH, acetic acid, and supraoptimal temperature.
Authorea,
Preprint Feb 9.
Editorial material
32 - Caspeta,L., Bustamante,V.H. (2022). Inducing Self-Poisoning: a Feasible Antibacterial Strategy?.
Journal of Bacteriology,
204 (12),
e0041122.
Editorial material
33 - Fletcher,E., Chen,Y., Caspeta,L., Feizi,A. (2022). Editorial: Genomic strategies for efficient microbial cell factories.
Frontiers in Bioengineering and Biotechnology,
10,
962828.
nacional divulgación
34 - Balderas,E., Caspeta,L. (2021). Cadenas de valor: de la refinería actual a las biorrefinerías.
Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM,
27,
31-35.
Editorial Material
35 - Caspeta,L., Buijs,N.A.A., Nielsen,J. (2013). The role of biofuels in the future energy supply.
Energy & Environmental Science,
6 (4),
1077-1082.
*
36 - Caspeta Guadarrama, Luis (2009). Escalamiento descendente del proceso de produccion de proteina heterologa por termoinduccion de cultivos de alta densidad celular de Escherichia coli : estudio de la respuesta transcripcional al choque termico .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Ramirez, Octavio T.
Revisión
37 - Perez-Morales,G., Merino,E., Cevallos,M.A., Gosset,G., Licona-Cassani,C., Caspeta,L., Martinez,A.. Toward a systems metabolic engineering approach to improve thermotolerance of Escherichia coli.
Microbial Cell Factories,
25,
108.
Artículo
38 - Martinez,J.A., Bouchat,R., Gallet de St Aurin,T., Martinez,L.M., Caspeta,L., Telek,S., Zicler,A., Gosset,G., Delvigne,F.. Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures.
Trends in Biotechnology,
43 (5),
1116-1139.
Artículo
39 - Molina-Vazquez,E.R., Caspeta,L., Gosset,G., Martinez,A.. Tailoring Escherichia coli BL21 (DE3) for preferential xylose utilization via metabolic and regulatory engineering.
Applied Microbiology and Biotechnology,
109 (1),
54.
Artículo
40 - Perez-Morales,G., Martinez-Conde,K.V., Caspeta,L., Merino,E., Cevallos,M.A., Gosset,G., Martinez,A.. Thermally adapted Escherichia coli keeps transcriptomic response during temperature upshift exposure.
Applied Microbiology and Biotechnology,
109 (1),
120.
Artículo
41 - Perez-Morales,G., Caspeta,L., Merino,E., Cevallos,M.A., Gosset,G., Martinez,A.. Simultaneous saccharification and fermentation for D-lactic acid production using a metabolically engineered Escherichia coli adapted to high temperature.
Biotechnology for Biofuels and Bioproducts,
17 (1),
132.
Preprint
42 - Martinez-Alvarez,J.A., Bouchat,R., Gallet de St Aurin,T., Martinez,L.M., Caspeta,L., Telek,S., Zicler,A., Gosset,G., Delvigne,F.. Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures.
bioRxiv,
Preprint posted May 14.
Artículo
43 - Avila-Fernandez, A., Montiel,S., Rodriguez Alegria, M.E., Caspeta,L., Lopez-Munguia,A.. Simultaneous enzyme production, Levan-type FOS synthesis and sugar by-products elimination using a recombinant Pichia pastoris strain expressing a levansucrase- endolevanase fusion enzyme.
Microbial Cell Factories,
22 (1),
18.
Artículo
44 - Salas-Navarrete,P.C., Rosas-Santiago,P., Suarez-Rodriguez,R., Martinez,A., Caspeta,L.. Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature.
Applied Microbiology and Biotechnology,
107 (12),
4051-4068.
Preprint
45 - Caspeta,L., Salas-Navarrete,P.C., Rosas-Santiago,P., Suarez-Rodriguez,R., Martinez,A.. Adaptive responses of evolved Saccharomyces cerevisiae strains tolerant to acidic pH, acetic acid, and supraoptimal temperature.
Authorea,
Preprint Feb 9.
artículo
46 - Salas-Navarrete,P.C., Montees de Oca Miranda,A.I., Martinez,A., Caspeta,L.. Evolutionary and reverse engineering to increase Saccharomyces cerevisiae tolerance to acetic acid, acidic pH, and high temperature.
Applied Microbiology and Biotechnology,
106 (1),
383-399.
Artículo
47 - Vera-Lopez-Portillo,F., Sierra-Ibarra,E., Vera-Estrella,R., Revah,S., Ramirez,O.T., Caspeta,L., Martinez,A.. Growth and phycocyanin production with Galdieria sulphuraria UTEX 2919 using xylose, glucose, and corn stover hydrolysates under heterotrophy and mixotrophy.
Algal Research,
65.
Editorial material
48 - Caspeta,L., Bustamante,V.H.. Inducing Self-Poisoning: a Feasible Antibacterial Strategy?.
Journal of Bacteriology,
204 (12),
e0041122.
Editorial material
49 - Fletcher,E., Chen,Y., Caspeta,L., Feizi,A.. Editorial: Genomic strategies for efficient microbial cell factories.
Frontiers in Bioengineering and Biotechnology,
10,
962828.
Artículo
50 - Caspeta,L., Kerkhoven,E.J., Martinez,A., Nielsen,J.. The yeastGemMap: A process diagram to assist yeast systems-metabolic studies.
Biotechnology and Bioengineering,
118 (12),
4800-4814.
nacional divulgación
51 - Balderas,E., Caspeta,L.. Cadenas de valor: de la refinería actual a las biorrefinerías.
Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM,
27,
31-35.
Internacional
52 - Caspeta,L., Salas-Navarrete,P.C.. Reduction of the Saccharomyces cerevisiae Genome: Challenges and Perspectives. Minimal Cells: Design, Construction, Biotechnological Applications.
117-139,
Cham: Springer International Publishing.
Internacional
53 - Caspeta, L., Castillo, T.. Systems Metabolic Engineering of Saccharomyces cerevisiae for Production of Biochemicals from Biomass. Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources.
31-65,
Cham.
*
Artículo
54 - Bertrand,B., Trejo-Hernandez,M.R., Morales-Guzman,D., Caspeta,L., Suarez-Rodriguez R., Martinez-Morales,F.. Functional expression, production, and biochemical characterization of a laccase using yeast surface display technology.
Fungal Biology,
120 (12),
1609-1622.
*
Artículo
55 - Caspeta,L., Chen,Y., Nielsen,J.. Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C.
Scientific Reports,
6,
27003.
*
Artículo
56 - Caspeta,L., Nielsen,J.. Thermotolerant Yeast Strains Adapted by Laboratory Evolution Show Trade-Off at Ancestral Temperatures and Preadaptation to Other Stresses.
MBio,
6 (4),
e00431.
*
Revisión
57 - Caspeta,L., Castillo,T., Nielsen,J.. Modifying Yeast Tolerance to Inhibitory Conditions of Ethanol Production Processes.
Frontiers in Bioengineering and Biotechnology,
3,
184.
*
Artículo
58 - Caspeta,L., Chen,Y., Ghiaci,P., Feizi,A., Buskov,S., Hallstrom,B.M., Petranovic,D., Nielsen,J.. Biofuels. Altered sterol composition renders yeast thermotolerant.
Science,
346 (6205),
75-78.
*
Carta
59 - Caspeta,L., Nielsen,J.. Economic and environmental impacts of microbial biodiesel.
Nature Biotechnology,
31 (9),
789-793.
*
Artículo
60 - Caspeta,L., Lara,A.R., Perez,N.O., FLORES,N., Bolivar,F., Ramirez,O.T.. Enhancing thermo-induced recombinant protein production in Escherichia coli by temperature oscillations and post-induction nutrient feeding strategies.
Journal of Biotechnology,
167 (1),
47-55.
Revisión
61 - Caspeta,L., Nielsen,J.. Toward systems metabolic engineering of Aspergillus and Pichia species for the production of chemicals and biofuels.
Biotechnology Journal,
8 (5),
534-544.
*
Editorial Material
62 - Caspeta,L., Buijs,N.A.A., Nielsen,J.. The role of biofuels in the future energy supply.
Energy & Environmental Science,
6 (4),
1077-1082.
*
Artículo
63 - Caspeta,L., Shoaie,S., Agren,R., Nookaew,I., Nielsen,J.. Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials.
BMC Systems Biology,
6,
24.
*
Artículo
64 - Lara,A.R., Knabben,I., Regestein,L., Sassi,J., Caspeta,L., Ramirez,O.T., Buchs,J.. Comparison of oxygen enriched air vs. pressure cultivations to increase oxygen transfer and to scale-up plasmid DNA production fermentations.
Engineering in Life Sciences,
11 (4),
382-386.
Artículo
65 - Soto,R., Caspeta,L., Barron,B., Gosset,G., Ramirez,O.T., Lara,A.R.. High cell-density cultivation in batch mode for plasmid DNA production by a metabolically engineered E. coli strain with minimized overflow metabolism.
Biochemical Engineering Journal,
56 (3),
165-171.
Revisión
66 - Valdez-Cruz,N.A., Caspeta,L., Perez,N.O., Ramirez,O.T., Trujillo-Roldan,M.A.. Production of recombinant proteins in E. coli by the heat inducible expression system based on the phage lambda pL and/or pR promoters.
Microbial Cell Factories,
9 (1),
18.
Artículo
67 - Caspeta,L., FLORES,N., Perez,N.O., Bolivar,F., Ramirez,O.T.. The effect of heating rate on Escherichia coli metabolism, physiological stress, transcriptional response, and production of temperature-induced recombinant protein: a scale-down study.
Biotechnology and Bioengineering,
102 (2),
468-482.
68 - Caspeta Guadarrama, Luis. Escalamiento descendente del proceso de produccion de proteina heterologa por termoinduccion de cultivos de alta densidad celular de Escherichia coli : estudio de la respuesta transcripcional al choque termico .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Ramirez, Octavio T.
Artículo
69 - Lara,A.R., Caspeta,L., Gosset,G., Bolivar,F., Ramirez,O.T.. Utility of an Escherichia coli strain engineered in the substrate uptake system for improved culture performance at high glucose and cell concentrations: An alternative to fed-batch cultures.
Biotechnology and Bioengineering,
99 (4),
893-901.
Artículo
70 - Villarreal,M.L., Caspeta,L., Quintero-Ramirez,R.. From the Mayan Highlands to the Bioreactors: In Vitro Tissue Culture of the Mexican Medicinal Plant Solanum chrysotrichum.
Electronic Journal of Integrative Biosciences,
3 (1),
20-28.
*
Artículo
71 - Caspeta,L., Quintero,R., Villarreal,M.L.. Novel airlift reactor fitting for hairy root cultures: developmental and performance studies.
Biotechnology Progress,
21 (3),
735-740.
*
Artículo
72 - Caspeta,L., Nieto,I., Zamilpa,A., Alvarez,L., Quintero,R., Villarreal,M.L.. Solanum chrysotrichum hairy root cultures: characterization, scale-up and production of five antifungal saponins for human use.
Planta Medica,
71 (11),
1084-1087.
*