Biología Molecular y Bioquímica de venenos de animales ponzoñosos

Nivel C del PRIDE
  • Doctorado, en Investigacion Biomedica Basica, IBt-UNAM (1995)

  • Maestría, Bioquímica, Fac. de Química-UNAM (1986)

  • Licenciatura, Químico Farmaceutico Biologo, FES-Cuautitlan-UNAM (1979)

  • Maestría
  • Rodolfo Miranda Espino

    Síntesis de péptidos sin puentes disulfuro derivados del transcriptoma de la glándula venenosa del alacrán Superstitionia donensis: evaluación de su actividad antimicrobiana

  • Licenciatura
2 - Vázquez Ramírez, José Noé (2021). Caracterización bioquímica de los componentes del veneno del alacrán Centruroides nigrescens. Escuela de Estudios Superiores del Jicarero, Jojutla, Licenciatura en Biología, Universidad Autónoma del Estado de Morelos. *
4 - Uribe Mendonza, Ivett (2015). Estudio de la interacción de la Imperatoxina A con el receptor de la Ryanodina por medio de ensayos de entrecruzamiento. Facultad de Ciencias Biológicas , Bióloga, Universidad Autónoma del Estado de Morelos. *
5 - Sanchez Vasquez, Lorenzo (2011). Diseno de nuevos peptidos : sinteticos antimicrobianos. Instituto de Biotecnologia, Maestria en Ciencias Bioquimicas, UNAM.
8 - Hernández Aponte,Cynthia Annabel (2009). Búsqueda, identificación y caracterización de componentes de venenos de alacranes Mexicanos con actividad antibacteriana. Centro de Investigación en Biotecnología , Maestro en Biotecnología, Universidad Autónoma del Estado de Morelos. *
9 - Hernández Aponte,Cynthia Annabel (2007). Caracterización bioquímica de componentes de bajo peso molecular del veneno del alacrán Centruroides noxius Hoffmann. Facultad de Ciencias Químicas e Ingeniería, Ingeniero Químico, Universidad Autónoma del Estado de Morelos. *
Total de publicaciones: 71
  • Tipo
  • Fecha
Open Access Artículo
13 - Haji-Ghassemi,O., Chen,Y.S., Woll,K., Gurrola,G.B., Valdivia,C.R., Cai,W., Li,S., Valdivia,H.H., Van Petegem,F. (2023). Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Science Advances, 9 (21), eadf4936.
Open Access Artículo
15 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G. (2022). sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity. Biochemical Pharmacology, 199, 115023.
Artículo
19 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H. (2016). Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands. Journal of General Physiology, 147 (5), 375-394.
Revisión
Artículo
21 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Powers,P.P., Willis,B.C., Moss,R.L., Jalife,J., Valdivia,H.H. (2015). Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function. Proceedings of the National Academy of Sciences of the United States of America, 112 (13), E1669-E1677.
Revisión
22 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Hernandez,J.J., Valdivia,H.H. (2015). Arrhythmogenic mechanisms in ryanodine receptor channelopathies. Science China Life Sciences, 58 (1), 54-58.
Artículo
25 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D. (2013). Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin. Biochimica et Biophysica Acta (BBA) - General Subjects, 1830 (6), 3427-3436.
Artículo
26 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D. (2012). Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry, 51 (19), 4049-4061.
Artículo
28 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G. (2012). Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells. Molecular Pharmacology, 82 (3), 372-382.
Revisión
32 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D. (2009). Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells. Toxicology Letters, 187 (1), 1-9.
Artículo; Actas Paper
34 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E. (2006). Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS. Molecular Pharmacology, 69 (5), 1673-1683.
Artículo
37 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M. (2004). Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels. Proteins, 56 (2), 367-375.
Artículo
38 - Rosales-Castillo,J.A., Acosta-Saavedra,L.C., Torres,R., Ochoa-Fierro,J., Borja-Aburto,V.H., Lopez-Carrillo,L., Garcia-Vargas,G.G., Gurrola,G.B., Cebrian,M.E., Calderon-Aranda,E.S. (2004). Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study. International Archives of Occupational and Environmental Health, 77 (6), 418-423.
Artículo
41 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E. (2002). Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release. Journal of Neuroscience, 22 (9), 3414-3425.
Artículo
43 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G. (2001). Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells. European Biophysics Journal, 29 (8), 569-573.
Artículo
44 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A. (2001). Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. Journal of Physiology, 534 (Pt 3), 721-732.
Open Access Artículo
48 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E. (1999). A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom. FASEB Journal, 13 (8), 953-962.
Open Access Artículo
49 - Gurrola,G.B., Arevalo,C., Sreekumar,R., Lokuta,A.J., Walker,J.W., Valdivia,H.H. (1999). Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor. Journal of Biological Chemistry, 274 (12), 7879-7886. *
Revisión
50 - Possani,L.D., Selisko,B., Gurrola,G.B. (1999). Structure and function of scorpion toxins affecting K+-channels. Perspectives In Drug Discovery And Design, 16, 15-40.
Artículo
51 - Samso,M., Trujillo,R., Gurrola,G.B., Valdivia,H.H., Wagenknecht,T. (1999). Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor. Journal of Cell Biology, 146 (2), 493-499. *
Artículo
55 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D. (1997). Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors. FEBS Letters, 405 (3), 385-389.
Artículo
61 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C. (1995). Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels. Biochemical and Biophysical Research Communications, 213 (3), 901-907.
Artículo
62 - Gurrola,G.B., Possani,L.D. (1995). Structural and functional features of noxiustoxin: a K+ channel blocker. Biochemistry and Molecular Biology International, 37 (3), 527-535.
Artículo
63 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D. (1995). Monoclonal antibodies against noxiustoxin. Hybridoma, 14 (3), 247-251.
Artículo
65 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D. (1994). Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch. Biochemical Journal, 304 (Pt 1), 51-56.
Artículo
67 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L. (1993). Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker. Journal of Membrane Biology, 134 (2), 123-129.
Artículo
68 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M. (1992). Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels. Toxicon, 30 (11), 1343-1364.
Artículo
71 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D. (1988). Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann. Toxicon, 26 (9), 785-794.
Artículo
Artículo
73 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D. (1987). Neurotoxins that act selectively on voltage-dependent cardiac calcium channels. Circulation Research, 61 (4 Pt 2), I6-I9.
Internacional
74 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R. (2011). Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas . 147-180, Mexico.
Internacional
75 - Gurrola,G.B., Zhu,X., Valdivia,H (2005). Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function. Ryanodine receptors : structure, function and dysfunction in clinical disease. Developments in Cardiovascular Medicine, 191-200, 254, New York.
Memoria in extenso
76 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D. (1991). Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America. 7 p, Caracas.
Memoria in extenso
77 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E. (1991). Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins. 352-367, Brasil.
Nacional
78 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D. (1984). Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos. 35-50.
Open Access Preprint
80 - Sheard,T.M.D., Howlett,L., Kirton,H., Yang,Z., Gurrola,G., Steele,D., Jayasinghe,I., Valdivia,H.H., Colyer,J. (2020). Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes. bioRxiv, Preprint posted June 28.
81 - Gurrola Briones, Georgina (1994). Caracterizacion funcional estructural de la noxiustoxina. Instituto de Biotecnologia, Doctorado en Investigacion Biomedica Basica, UNAM.
83 - Gurrola Briones, Georgina (1981). Busqueda e identificacion de anticuerpos contra antigenos del sistema hla . FES Cuautitlan, Quimico Farmaceutico Biologo, UNAM. *
Asesor: Teran Ortiz, Luis Angel

Open Access Artículo
85 - Haji-Ghassemi,O., Chen,Y.S., Woll,K., Gurrola,G.B., Valdivia,C.R., Cai,W., Li,S., Valdivia,H.H., Van Petegem,F.. Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Science Advances, 9 (21), eadf4936.
Open Access Artículo
Open Access Artículo
87 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G.. sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity. Biochemical Pharmacology, 199, 115023.
Artículo
Open Access Preprint
89 - Sheard,T.M.D., Howlett,L., Kirton,H., Yang,Z., Gurrola,G., Steele,D., Jayasinghe,I., Valdivia,H.H., Colyer,J.. Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes. bioRxiv, Preprint posted June 28.
Artículo
92 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H.. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands. Journal of General Physiology, 147 (5), 375-394.
Revisión
Artículo
94 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Powers,P.P., Willis,B.C., Moss,R.L., Jalife,J., Valdivia,H.H.. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function. Proceedings of the National Academy of Sciences of the United States of America, 112 (13), E1669-E1677.
Revisión
95 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Hernandez,J.J., Valdivia,H.H.. Arrhythmogenic mechanisms in ryanodine receptor channelopathies. Science China Life Sciences, 58 (1), 54-58.
Revisión
106 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D.. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells. Toxicology Letters, 187 (1), 1-9.
Open Access Artículo
Internacional
111 - Gurrola,G.B., Zhu,X., Valdivia,H. Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function. Ryanodine receptors : structure, function and dysfunction in clinical disease. Developments in Cardiovascular Medicine, 191-200, 254, New York.
Artículo
112 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M.. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels. Proteins, 56 (2), 367-375.
Artículo
113 - Rosales-Castillo,J.A., Acosta-Saavedra,L.C., Torres,R., Ochoa-Fierro,J., Borja-Aburto,V.H., Lopez-Carrillo,L., Garcia-Vargas,G.G., Gurrola,G.B., Cebrian,M.E., Calderon-Aranda,E.S.. Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study. International Archives of Occupational and Environmental Health, 77 (6), 418-423.
Artículo
Artículo
116 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E.. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release. Journal of Neuroscience, 22 (9), 3414-3425.
Artículo
Artículo
Artículo
119 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A.. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. Journal of Physiology, 534 (Pt 3), 721-732.
Open Access Artículo
Open Access Artículo
123 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E.. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom. FASEB Journal, 13 (8), 953-962.
Open Access Artículo
124 - Gurrola,G.B., Arevalo,C., Sreekumar,R., Lokuta,A.J., Walker,J.W., Valdivia,H.H.. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor. Journal of Biological Chemistry, 274 (12), 7879-7886. *
Revisión
125 - Possani,L.D., Selisko,B., Gurrola,G.B.. Structure and function of scorpion toxins affecting K+-channels. Perspectives In Drug Discovery And Design, 16, 15-40.
Artículo
126 - Samso,M., Trujillo,R., Gurrola,G.B., Valdivia,H.H., Wagenknecht,T.. Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor. Journal of Cell Biology, 146 (2), 493-499. *
Artículo
Artículo
Artículo
Artículo
136 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C.. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels. Biochemical and Biophysical Research Communications, 213 (3), 901-907.
Artículo
137 - Gurrola,G.B., Possani,L.D.. Structural and functional features of noxiustoxin: a K+ channel blocker. Biochemistry and Molecular Biology International, 37 (3), 527-535.
Artículo
138 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D.. Monoclonal antibodies against noxiustoxin. Hybridoma, 14 (3), 247-251.
Artículo
143 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L.. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker. Journal of Membrane Biology, 134 (2), 123-129.
Memoria in extenso
146 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D.. Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America. 7 p, Caracas.
Memoria in extenso
147 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E.. Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins. 352-367, Brasil.
Artículo
151 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D.. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels. Circulation Research, 61 (4 Pt 2), I6-I9.
152 - Gurrola Briones, Georgina. Sintesis quimica de peptidos correspondientes a secuencias de aminoacidos de toxinas de alacran y sus propiedades. Instituto de Biotecnologia, Maestro en Ciencias Quimicas (Bioquimica), UNAM.
Asesor: Teran Ortiz, Luis Angel

Nacional
153 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D.. Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos. 35-50.
154 - Gurrola Briones, Georgina. Busqueda e identificacion de anticuerpos contra antigenos del sistema hla . FES Cuautitlan, Quimico Farmaceutico Biologo, UNAM. *
Asesor: Teran Ortiz, Luis Angel