Dr. Francisco Xavier del Espíritu Santo Soberon Mainero
Investigador Titular C Tiempo Completo
Estructura, Función y Manipulación de Péptidos y Proteínas
Genómica y transcriptomica de patógenos y parásitos
Número de registros: 6
- Vencidos
- Exploración del espacio de variantes del dominio de unión al receptor (ace2) del virus sars-cov-2 mediante redes neurales, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2022 - 2024
- Evolución dirigida del dominio de prefenato deshidrogenasa de la proteína t de e. coli, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2016 - 2019
- Evolución dirigida de proteínas, PRESUPUESTO UNAM, 2014 - 2020
- Estudios evoulutivos y mecanísticos de la enzima bifuncional fosforibosil isomerasa (pria) presente en bacterias del grupo de los actinomicetos., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2005 - 2006
- Diseño y desarrollo de un andamiaje estable para evolución dirigida de actividades catalíticas., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2007
- Evolución dirigida de proteínas: desarrollo de conceptos y metodologías para la generación de reconocimiento y catálisis de novo, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1997 - 2002
Nivel D del PRIDE
Nivel Investigador Emérito del SNII
Nivel Investigador Emérito del SNII
Doctorado, en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-CEINGEBI-UNAM (1984)
Maestría, en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-UNAM (1981)
Licenciatura, Química, Universidad Iberoamericana (1978)
Premio Nacional de Química "Andrés Manuel del Río", Sociedad Química de México, 1999
- Graduados
1 - Galeana Cadena, David (2024). Metagenoma en muestra clinica de pacientes con infecciones del tracto respiratorio.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
2 - Uribe Vazquez, Brenda Georgina (2024). Caracterizacion bioquimica, biofisica y estructural de variantes de KatG que confieren resistencia a isoniazida en Mycobacterium tuberculosis.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
3 - Guerrero Corona, Diego (2019). Microbioma de tracto respiratorio en pacientes con infecciones respiratorias agudas .
INMEGEN,
Maestria en Ciencias Bioquimicas,
UNAM.
*
4 - Cruz Correa, Omar Fernando (2019). Caracterizacion de la diversidad en genes importantes de farmacogenomica mediante secuenciacion de nueva generacion .
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
5 - Uribe Vazquez, Brenda Georgina (2017). Caracterizacion funcional de mutaciones nuevas en KatG de mycobacterium tuberculosis resistente a isoniazida encontradas en aislados clinicos de pacientes mexicanos .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
6 - Lopez de los Santos, Yossef (2014). Ingenieria de las proteinas del sistema pts en escherichia coli.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
7 - Cruz Correa, Omar Fernando (2013). Desarrollo de pruebas genomicas prioritarias para la salud publica de Mexico .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
8 - Cantu Alessio Robles, Vito Adrian (2013). Analisis de una libreria binaria de mutantes de NPR .
Instituto de Biotecnologia,
Maestria en Ciencias,
UNAM.
9 - Ochoa Leyva, Adrian (2011). Explorando la relacion estructurafuncion de las asas SS/a de un barril (SS/a)8 : implicaciones para el diseno de nuevas funciones enzimaticas .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
10 - Verdel Aranda, Karina (2009). Cinetica enzimatica de fosforribosil antranilato isomerasas (PRAI) obtenidas por evolucion dirigida .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
11 - Flores Escobar, Biviana (2008). Diseno y construccion de variantes de la enzima fosforribosil antranilato isomerasa (PRAI) con asas de aldolasas clase I .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
12 - Gaytan Colin, Ruben Paul (2003). Nuevas estrategias de sintesis de DNA para la evolucion dirigida de proteinas : generacion y enriquecimiento de bibliotecas con mutantes de baja multiplicidad.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
13 - Riano Umbarila, Lidia (2000). Desarrollo de un sistema de seleccion para la actividad de aldolasa .
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
UNAM.
14 - Ledezma Candanoza, Luis Moises (2000). Estudio de la catalisis y del reconocimiento especifico al ADN por la endonucleasa EcoRI .
Instituto de Biotecnologia,
Maestria en Ciencias Biomedicas,
UNAM.
15 - Gonzalez Zuniga, Victor Manuel (1998). El mecanismo de activacion trascripcional a distancia en bacteria y la region de control positivo de NifA .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
16 - Chihu Amparan, Lilia (1998). Mutagenesis combinatoria de la region del sitio activo de la beta lactamasa tem1 de Escherichia coli .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
Asesor: Soberon Mainero, Francisco Xavier, Fuchs Gomez, Lidia Yolanda
17 - Rio Guerra, Gabriel del (1997). Estudio del sitio catalitico de una alfaamilasa por medio de ingenieria de proteinas .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
18 - Flores Soto, Humberto (1995). Analisis del reconocimiento molecular por medio de ingenieria de proteinas.
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
19 - Cota Segura, Ernesto (1995). Estudio de regiones conservadas de la betalactamasa clase A de E. coli.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
20 - Viadiu Ilarraza, Hector (1994). Modificacion de la especificidad de la Blactamasa por mutagenesis combinatoria.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
21 - Rio Guerra, Gabriel del (1994). Mutagenesis de residuos involucrados en la estabilidad al PH alcalino de la penicilino acilasa de E. coli .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
22 - Ramirez Alvarado, Marina (1994). Ingenieria de proteinas para reacciones de alcoholisis mutagenesis combinatoria de alfaamilasa .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
23 - Flores Soto, Humberto (1994). Analisis de la intervencion DNA proteina de la endonucleasa Ecori, por medio de mutagenesis dirigida .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
24 - Osuna Quintero, Joel (1992). Analisis del sitio activo de enzimas mediante mutagenesis combinatoria .
Instituto de Biotecnologia,
Doctor en Investigacion Biomedica Basica,
UNAM.
25 - Munguia Zamudio, Maria Elena (1992). Clonacion y expresion del fragmento C de la toxina tetanica en Escherichia coli .
Instituto de Biotecnologia,
Maestroia en Biotecnologia,
UNAM.
26 - Flores Soto, Humberto (1991). Caracterizacion de mutantes en el sitio de reconocimiento de la endonucleasa Eco RI .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
27 - Osuna Quintero, Joel (1989). Aislamineto de un fragmento inmunogenico de toxina tetanica.
CEINGEBI,
Maestria en Investigacion Biomedica Basica,
UNAM.
28 - Cruz Reyes, Jorge Armando (1989). Un sistema experimental para el aislamiento del sustrato minimo de replicacion en plasmidos tipo Col E1 .
CEINGEBI,
Licenciatura en Investigacion Biomedica Basica,
UNAM.
29 - Munguia Zamudio, Maria Elena (1987). Estudios sobre estabilidad y replicacion inducible en plasmidos tipo col el .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
30 - Lomeli Buyoli, Hilda Maria (1987). Determinacion de una region hacia arriba del promotor requerida para la transcripcion optima del primero de replicacion del plasmido pBR327 .
CEINGEBI,
Maestria en Investigacion Biomedica Basica,
UNAM.
31 - Lomeli Buyoli, Hilda Maria (1984). Introduccion de un sitio de restriccion adyacente al origen de replicacion del plasmido pBR327.
Escuela Nacional de Estudios Superiores Zaragoza,
Quimico Farmaceutico Biologo,
UNAM.
*
32 - Cuevas Guerrero, Mario Alberto (1983). Sintesis de polinucleotidos mediante tecnica estandarizada .
FES Zaragoza,
Quimico Farmaceutico Biologo,
UNAM.
*
* Indica publicación con otra institución de adscripción
Total de publicaciones: 133
- Tipo
- Fecha
Artículo
33 - Oropeza-Valdez,J.J., Padron-Manrique,C., Arellano-Villavicencio,J.E., Vazquez-Jimenez,A., Hernandez-Juarez,L.E., Soberon,X., Reyes-Escogido,M.L., Guardado-Mendoza,R., Resendis-Antonio,O. (2026). Digital modeling of metformin and diet interactions on gut-microbiota metabolism in prediabetic patients.
Computational and Structural Biotechnology Journal,
31,
250-262.
Artículo
34 - Alvarado-Pena,N., Munoz-Torrico,M., Narvaez-Diaz,L., Mejia-Ponce,P.M, Becerril-Vargas,E., Zuniga,J., Muniz-Salazar,R., Laniado-Laborin,R., Licona-Cassani,C., Soberon,X., Silva-Herzog,E. (2025). Mycobacterium tuberculosis genomic surveillance in Mexico. Characterization of variants in drug resistance and efflux pump genes.
Frontiers in Microbiology,
16,
1666838.
Artículo
35 - Anwar,S., Lamaudiere,M., Hassall,J., Dehinsilu,J., Bhuller,R.K., Hold,G.L., VAzquez-Campos,X., Mahnert,A., Moissl-Eichinger,C., Galle,B., Kainz,G., Pjevac,P., Hausmann,B., Schwarz,J., Kohl,G., Berry,D., Vancuren,S.J., len-Vercoe,E., Nielsen,N., Sorensen,N., Eklund,A., Nielsen,H.B., Riedel,R., Krause,J.L., Chang,H.-D., Park,S., Song,H.-Y., Seo,H., Ul-Haq,A., Kim,S., Kwon,Y., Park,S., Soberon,X., Silva-Herzog,E., Verlouw,J.A.M., Arp,P., Jhamai,M., Kraaij,R., Geelen,A.R., Ducarmon,Q.R., Smits,W.K., Kuijper,E.J., Zwittink,R.D., van,Best N., Penders,J., Le,G., Driessen,C., Kool,J., Shetty,S.A., Fuentes,S., Demirci,M., Yigin,A., Whalley,C., Beggs,A.D., Quince,C., James,R., Raguideau,S., Gordon,M., Mate,R., Fritzsche,M., Danckert,N.P., Blanco,J.M., Marchesi,J.R., Rauch,M., Williamson,R.A., Van't Wout,A.B., Kritz,A., Rosecker,S., Stevens,R., Laws,L., Sayavedra,L., Romano,S., Telatin,A., Baker,D., Narbad,A., Servetas,S.L., Kralj,J.G., Forry,S.P., Hunter,M.E., Dootz,J.N., Jackson,S.A., Mason,C.E., Butler,D.J., Mozsary,C., Foox,J., Damle,N., Resh,A., Busswitz,A., Lenz,P., Sontag,S., Cross,A., Sanchez,C., Guo,M., Olson,K., Smith,E.A., La Reau,A.J., Ward,T., Kuersten,S., Hyde,F., Khrebtukova,I., Schroth,G., Rijpkema,S., Amos,G.C.A., Sergaki,C. (2025). DNA reference reagents isolate biases in microbiome profiling: a global multi-lab study.
mSystems,
10 (11),
e00466-25.
Artículo
36 - Arevalo-Salina,E.L., Nishigaki,T., Olvera,L., Gonzalez-Andrade,M., Xolalpa-Villanueva,W., Lopez-Romero,E.O., Soberon,X., Saab-Rincon,G. (2025). Change in selectivity of estrogen receptor alpha ligand-binding domain by mutations at residues H524/L525.
Biochimica et Biophysica Acta.General Subjects,
1869 (4),
130775.
Artículo
37 - Tobon,E., Riano-Umbarila,L., Flores,H., Gutierrez,M., Soberon,X., Becerril-Lujan,B., Ramirez,O.T., Rudino-Pinera,E. (2025). Functional expression of five refolded recombinant variants of RBD from SARS-CoV-2 in Escherichia coli.
Protein Expression and Purification,
235,
106781.
Artículo
38 - Galeana-Cadena,D., Ramirez-Martinez,G., Choreno-Parra,J.A., Silva-Herzog,E., Hernandez-Cardenas,C.M., Soberon,X., Zuniga,J. (2024). Microbiome in the Nasopharynx: Insights into the Impact of COVID-19 Severity.
Heliyon,
10 (10),
e31562.
Artículo
39 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O. (2024). Exploring metabolic anomalies in COVID-19 and post-COVID-19: a machine learning approach with explainable artificial intelligence.
Frontiers in Molecular Biosciences,
11,
1429281.
Artículo
40 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X (2024). Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Revisión
41 - Alvarado-Pena,N., Galeana-Cadena,D., Gomez-Garcia,I.A, Soberon-Mainero,X, Silva-Herzog,E (2023). The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment.
Frontiers in Microbiology,
14,
1237998.
Artículo
42 - Barbosa-Amezcua,M., Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Carrillo-Sanchez,K., Mata-Rocha,M., Munoz-Torrico,M., Backer,C., Gonzalez-Covarrubias,V., Alaez-Verson,C., Soberon,X. (2022). Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Microbiology Spectrum,
10 (5),
e0125222.
Artículo
43 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Juarez-Rojop,I.E., Tovilla-Zarate,C.A., Soberon,X., Lanzagorta,N., Nicolini,H. (2022). Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.
Brazilian Journal of Psychiatry,
44 (2),
164-170.
*
Artículo
44 - Aguilar-Ordonez,I., Perez-Villatoro,F., Garcia-Ortiz,H., Barajas-Olmos,F., Ballesteros-Villascan,J., Gonzalez-Buenfil,R., Fresno,C., Garciarrubio,A., Fernandez-Lopez,J.C., Tovar,H., Hernandez-Lemus,E., Orozco,L., Soberon,X., Morett,E. (2021). Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.
PLoS ONE,
16 (4),
e0249773,
[correction May 25 2022].
artículo
45 - Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Barbosa-Amezcua,M., Mata-Rocha,M., Munoz-Torrico,M., Salazar-Lezama,M.A., Martinez-Orozco,J.A., Narvaez-Diaz,L.A., Salas-Hernandez,J., Gonzalez-Covarrubias,V., Soberon,X. (2021). A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.
PLoS ONE,
16 (10),
e0258774.
*
Artículo
46 - Gonzalez-Covarrubias,V,, Sanchez-Ibarra,H., Lozano-Gonzalez, K., Villicana, S., Texis,T., Rodriguez-Dorantes,M., Cortes-Ramirez,S., Lavalle-Gonzalez,F,, Soberon,X., Barrera-Saldana,H. (2021). Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.
Pharmacology,
106 (11-12),
588-596.
Artículo
47 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P. (2021). Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
162[comentario vol 162 (9) pp 1-2] (8).
Artículo
48 - Valdez-Palomares,F., Munoz-Torrico,M., Palacios-Gonzalez,B., Soberon,X., Silva-Herzog,E. (2021). Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers.
Microorganisms,
9 (8),
1762.
Revisión
49 - Gonzalez-Covarrubias,V., Lozano,K., Texis,T., Guzman-Cruz,C.K., Rodriguez-Dorantes,M., Rubio-Carrasco,K., Mendez-Lorenzo,L.H., Soberon,X. (2020). Pharmacogenomics: Current Actionable Variants.
Revista de Investigacion Clinica,
73 (3).
*
Artículo
50 - Cabrera-Contreras,R., Santamaria,R.I., Bustos,P., Martinez-Flores,I., Melendez-Herrada,E., Morelos-Ramirez,R., Barbosa-Amezcua,M., Gonzalez-Covarrubias,V., Silva-Herzog,E., Soberon,X., Gonzalez,V. (2019). Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey.
PeerJ,
7,
e8068.
*
Artículo
51 - Flannick,J., Mercader,J.M., Fuchsberger,C., Udler,M.S., Mahajan,A., Wessel,J., Teslovich,T.M., Caulkins,L., Koesterer,R., Barajas-Olmos,F., Blackwell,T.W., Boerwinkle,E., Brody,J.A., Centeno-Cruz,F., Chen,L., Chen,S., Contreras-Cubas,C., Cordova,E., Correa,A., Cortes,M., Defronzo,R.A., Dolan,L., Drews,K.L., Elliott,A., Floyd,J.S., Gabriel,S., Garay-Sevilla,M.E., Garcia-Ortiz,H., Gross,M., Han,S., Heard-Costa,N.L., Jackson,A.U., Jorgensen,M.E., Kang,H.M., Kelsey,M., Kim,B.J., Koistinen,H.A., Kuusisto,J., Leader,J.B., Linneberg,A., Liu,C.T., Liu,J., Lyssenko,V., Manning,A.K., Marcketta,A., Malacara-Hernandez,J.M., Martinez-Hernandez,A., Matsuo,K., Mayer-Davis,E., Mendoza-Caamal,E., Mohlke,K.L., Morrison,A.C., Ndungu,A., Ng,M.C.Y., O'Dushlaine,C., Payne,A.J., Pihoker,C., Post,W.S., Preuss,M., Psaty,B.M., Vasan,R.S., Rayner,N.W., Reiner,A.P., Revilla-Monsalve,C., Robertson,N.R., Santoro,N., Schurmann,C., So,W.Y., Soberon,X., Stringham,H.M., Strom,T.M., Tam,C.H.T., Thameem,F., Tomlinson,B., Torres,J.M., Tracy,R.P., van Dam,R.M., Vujkovic,M., Wang,S., Welch,R.P., Witte,D.R., Wong,T.Y., Atzmon,G., Barzilai,N., Blangero,J., Bonnycastle,L.L., Bowden,D.W., Chambers,J.C., Chan,E., Cheng,C.Y., Cho,Y.S., Collins,F.S., de Vries,P.S., Duggirala,R., Glaser,B., Gonzalez,C., Gonzalez,M.E., Groop,L., Kooner,J.S., Kwak,S.H., Laakso,M., Lehman,D.M., Nilsson,P., Spector,T.D., Tai,E.S., Tuomi,T., Tuomilehto,J., Wilson,J.G., guilar-Salinas,C.A., Bottinger,E., Burke,B., Carey,D.J., Chan,J.C.N., Dupuis,J., Frossard,P., Heckbert,S.R., Hwang,M.Y., Kim,Y.J., Kirchner,H.L., Lee,J.Y., Lee,J., Loos,R.J.F., Ma,R.C.W., Morris,A.D., O'Donnell,C.J., Palmer,C.N.A., Pankow,J., Park,K.S., Rasheed,A., Saleheen,D., Sim,X., Small,K.S., Teo,Y.Y., Haiman,C., Hanis,C.L., Henderson,B.E., Orozco,L., Tusie-Luna,T., Dewey,F.E., Baras,A., Gieger,C., Meitinger,T., Strauch,K., Lange,L., Grarup,N., Hansen,T., Pedersen,O., Zeitler,P., Dabelea,D., Abecasis,G., Bell,G.I., Cox,N.J., Seielstad,M., Sladek,R., Meigs,J.B., Rich,S.S., Rotter,J.I., Altshuler,D., Burtt,N.P., Scott,L.J., Morris,A.P., Florez,J.C., McCarthy,M.I., Boehnke,M. (2019). Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature,
570 (7759),
71-76.
*
Artículo
52 - Gonzalez-Covarrubias,V., Morales-Franco,M., Cruz-Correa,O.F., Martinez-Hernandez,A., Garcia-Ortiz,H., Barajas-Olmos,F., Genis-Mendoza,A.D., Martinez-Magana,J.J., Nicolini,H., Orozco,L., Soberon,X. (2019). Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.
Frontiers in Pharmacology,
10,
1169.
*
Artículo
53 - Madrazo-Moya,C.F., Cancino-Munoz,I., Cuevas-Cordoba,B., Gonzalez-Covarrubias,V., Barbosa-Amezcua,M., Soberon,X., Muniz-Salazar,R., Martinez-Guarneros,A., Backer,C., Zarrabal-Meza,J., Sampieri-Ramirez,C., Enciso-Moreno,A., Lauzardo,M., Comas,I., Zenteno-Cuevas,R. (2019). Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
PLoS ONE,
14 (6),
e0213046.
*
Artículo
54 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Jimenez-Guenchi,J., Galindo-Chavez,A.G., Roche-Bergua,A., Castaneda-Gonzalez,C., Lanzagorta,N., Soberon,X., Nicolini,H. (2019). Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia.
Revista de Investigacion Clinica,
71 (4),
246-254.
*
Artículo
55 - Ayon-Nunez, D.A., Fragoso, G., Espitia, C., Garcia-Varela, M., Soberon, X., Rosas, G., Laclette, J.P., Bobes, R.J. (2018). Identification and characterization of Taenia solium enolase as a plasminogen-binding protein.
Acta Tropica,
182,
69-79.
*
Artículo
56 - Flores-Bautista, J., Navarrete-Perea, J., Fragoso, G., Flisser, A., Soberon, X., Laclette, J.P. (2018). Fate of uptaken host proteins in Taenia solium and Taenia crassiceps cysticerci.
Bioscience Reports,
38 (4),
BSR20180636.
*
Artículo
57 - Bikel, S., Jacobo-Albavera, L., Sanchez-Munoz, F., Cornejo-Granados, F., Canizales-Quinteros, S., Soberon, X., Sotelo-Mundo, R.R., Del Rio-Navarro, B.E., Mendoza-Vargas, A., Sanchez, F., Ochoa-Leyva, A. (2017). A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data.
PeerJ,
5,
e4133.
Artículo
58 - Bobes, R.J., Navarrete-Perea, J., Ochoa-Leyva, A., Anaya, V.H., Hernandez, M., Cervantes-Torres, J., Estrada, K., Sanchez-Lopez, F., Soberon, X., Rosas, G., Maroni-Nunes C., Garcia-Varela, M., Sotelo-Mundo, R.R., Lopez-Zavala, A.A., Gevorkian, G., Acero, G., Laclette, J.P., Fragoso, G., Sciutto, E. (2017). Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen.
Infection and Immunity,
85,
e00395-17.
Artículo
59 - Cruz-Correa, O.F., Leon-Cachon, R.B., Barrera-Saldana, H.A., Soberon, X. (2017). Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing.
Pharmacogenomics,
18 (2),
121-131.
Artículo
60 - Gonzalez-Covarrubias, V., Urena-Carrion, J., Villegas-Torres, B., Cossio-Aranda, J.E., Trevethan-Cravioto, S., Izaguirre-Avila, R., Fiscal-Lopez, O.J., Soberon, X. (2017). Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol.
Frontiers in Pharmacology,
8,
863.
*
Artículo in consortium
61 - Marquez-Luna,C., Loh,P.R., Price,A.L., South Asian Type 2 Diabet SAT2D, SIGMA Type 2 Diabet Consortium, Soberon,X. (2017). Multiethnic polygenic risk scores improve risk prediction in diverse populations.
Genetic Epidemiology,
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121 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D. (1994). The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
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Revisión
122 - Osuna,J., Flores,H., Soberon,X. (1994). Microbial systems and directed evolution of protein activities.
Critical Reviews in Microbiology,
20 (2),
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Artículo
123 - Merino,E., Osuna,J., Bolivar,F., Soberon,X. (1992). A general, PCR-based method for single or combinatorial oligonucleotide-directed mutagenesis on pUC/M13 vectors.
Biotechniques,
12 (4),
508-510.
Artículo
124 - Pereyra-Alferez,B., Bravo,A., Quintero,R., Soberon,X. (1992). The delta-endotoxin protein family displays a hydrophobic motif that might be implicated in toxicity.
Molecular Microbiology,
6 (15),
2095-2098.
Artículo
125 - Lopez,S., Lopez,I., Romero,P., Mendez,E., Soberon,X., Arias,C.F. (1991). Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein.
Journal of Virology,
65 (7),
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Artículo
Note
127 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L. (1990). Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
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128 - Pastor,N., Pinero,D., Valdes,A.M., Soberon,X. (1990). Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation.
Molecular Microbiology,
4 (11),
1957-1965.
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129 - Balbas,P., Soberon,X., Merino,E., Zurita,M., Lomeli,H., Valle,F., FLORES,N., Bolivar,F. (1986). Plasmid vector pBR322 and its special-purpose derivatives--a review.
Gene,
50 (1-3),
3-40.
Note
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131 - Rossi,J.J., Soberon,X., Marumoto,Y., McMahon,J., Itakura,K. (1983). Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.
Proceedings of the National Academy of Sciences of the United States of America,
80 (11),
3203-3207.
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Artículo
132 - Inouye,S., Soberon,X., Franceschini,T., Nakamura,K., Itakura,K., Inouye,M. (1982). Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
Proceedings of the National Academy of Sciences of the United States of America,
79 (11),
3438-3441 .
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Artículo
133 - Miyada,C.G., Soberon,X., Itakura,K., Wilcox,G. (1982). The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r.
Gene,
17 (2),
167-177.
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Artículo
134 - Zarucki-Schulz,T., Tsai,S.Y., Itakura,K., Soberon,X., Wallace,R.B., Tsai,M.J., Woo,S.L., O'Malley,B.W. (1982). Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription.
Journal of Biological Chemistry,
257 (18),
11070-11077.
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Artículo
135 - Covarrubias,L., Cervantes,L., Covarrubias,A., Soberon,X., Vichido,I., Blanco,A., Kupersztoch-Portnoy,Y.M., Bolivar,F. (1981). Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328.
Gene,
13 (1),
25-35.
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Artículo
136 - Soberon,X., Covarrubias,L., Bolivar,F. (1980). Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.
Gene,
9 (3-4),
287-305.
*
Nacional
137 - Soberon,X. (2012). La medicina genómica en México, consideraciones para su desarrollo. Fortalezas y desafíos de los servicios de salud de México en el siglo XXI.
202-205.
Internacional
138 - Frausto-Solis,J., Soberon-Mainero,X., Linan-Garcia,E. (2009). MultiQuenching annealing algorithm for protein folding problem. Mexican International Conference on Artificial Intelligence. MICAI 2009: Advances in Artificial Intelligence .
Lecture Notes in Computer Science ,
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Nacional
139 - Segovia,L., Soberon,X. (2008). Evolución experimental de proteínas. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 26.
291-302,
Mexico, D.F..
Internacional
140 - Barona-Gomez,F., Ochoa-Leyva,A., Soberon,X. (2007). Advances and perspectives in protein engineering: from natural history to directed evolution of enzymes. Advances in Protein Physical Chemistry.
407-438,
Kerala: Research Signpost.
Memoria in extenso
141 - Frausto-Solis,J., Roman,E.F., Romero,D., Soberon,X., Linan-Garcia,E. (2007). Analytically tuned simulated annealing applied to the protein folding problem. Lecture Notes in Computer Science vol 4488.
370-377.
Nacional
142 - Soberon,X., Montero,G.M. (2004). Ingeniería de proteínas y evolución dirigida. Fundamentos y casos exitosos de la biotecnologia moderna cap 7.
195-217,
Mexico.
Nacional
143 - Soberon,X. (2003). Biocatálisis y evolución dirigida de proteínas. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.
35-45,
Mexico,D.F..
Nacional
Memoria in extenso
145 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A. (2002). Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Nacional
146 - Soberon,X., Bolivar,F. (2001). Evolución de los conceptos de gen y genoma. Ciencias de la vida.
61-83.
Internacional
147 - Balbas,P., Soberon,X., Bolivar,F., Rodriguez,R.L. (1988). The plasmid, pBR322. Biotechnology (Reading, Mass.).
5-41,
10.
Divulgación
148 - Soberon, X., Bergna, M., Valez, M. A. (2018). Iguales o difererentes? Genómica.
64 pp,
Ciudad de Mexico: Ediciones Tecolote.
Nacional
149 - Bolivar-Zapata, F.G., Arias-Ortiz, C. F., Artega-Vazquez, M. A., Barrera-Saldana, H. A., Galindo-Fentanes, E., Gracia-Gasca, A., Herrera-Estrella, L. R., Higuera-Ciapara, I., Larque-Saavedra, F. A., Lopez-Munguia Canales, A., Ramirez-Reivich, O. T., Revah-Moiseev, S., Soberon-Mainero, X., Torres-Pacheco, I., Uribe de la Mora, J. M., Vazquez-Ramos, J. M., Viniegra-Gonzalez, G. (2017). Transgénicos: Grandes beneficios, ausencia de daños y mitos.
Mexico.
Nacional
150 - Bolivar-Zapata,F.G., Arias-Ortiz,C.F., Arriaga-Arellano,E., Barrera-Saldaña,H., de la Torres-Martinez,M., Espinosa-Fernandez,J., Galindo-Fentanes,E., Galvez-Mariscal,A, Gracia-Gasca,A., Herrera-Estrella,L., Larque-Saavedra,A., Lopez-Munguia Canales,A., Noyola-Robles,A., Paredes-Lopez,O., Ramirez-Reivich,O.T., Revah-Moiseev,S., Soberon-Mainero,J., Soberon-Mainero,X., Torres-Pacheco,I., Uribe de la Mora,J., Viniegra-Gonzalez,G. (2011). Por un uso responsable de los organismos genéticamente modificados.
Mexico.
Preprint
151 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O. (2024). Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence.
bioRxiv,
Preprint posted April 17,
2024.
Nacional divulgacion
152 - Soberon-Mainero,X. (2023). La Ingeniería Genética: una muy poderosa técnica, definidora de una carrera científica.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
35.
Editorial Material, Meeting Report
153 - Cornejo-Granados,F., Calderon de la Barca,A.M., Torres,N., Martinez-Romero,E., Torres,J., Lopez-Vidal,Y., Soberon,X., Partida-Martinez,L.P., Pinto-Cardoso,S., Alcaraz,L.D., Pardo-Lopez,L., Canizales-Quinteros,S., Puente,J.L., Ochoa-Leyva,A. (2019). Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country.
Research in Microbiology,
170 (4-5),
235-241.
Divulgación
154 - Soberon-Mainero,X., Gonzalez-Covarrubias,V. (2014). Enfermedades infecciosas, hacia una medicina personalizada.
Revista Digital Universitaria,
15 (6),
art 43.
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Editorial Material
155 - Soberon-Mainero,X., Melendez-Zajgla,J. (2010). [The Instituto Nacional de Medicina Genomica. Vocation and challenges].
Revista de Investigacion Clinica,
62 (5),
391-392.
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Nacional
156 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G. (2006). Metabolic via engineering for the production of aromatic substances in Escherichia coli.
Revista Latinoamericana de Microbiologia,
48 (2),
92.
Nacional
157 - Yanez,J., Soberon,X., Gaytan,P. (2004). Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos.
Revista de la Sociedad Química de México,
48 (1),
26-37.
Divulgación
158 - Soberon Mainero,X (2003). Veinte años del Instituto de Biotecnología.
Revista Universidad de Mexico,
629.
Divulgación
159 - Soberon Mainero, X. (2002). La revolución de las ciencias genómicas.
Revista Universidad Nacional,
617.
Divulgación
160 - Soberon-Mainero,X. (2002). La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia.
Mensaje Bioquimico,
26,
1-18.
Divulgación
161 - Soberon,X. (2001). Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales.
Revista Universidad de Mexico,
605-606,
59-63.
Divulgación
162 - Soberon,X. (2000). El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.
BioTecnologia. Sociedad Mexicana de Biotecnologia y Bioingenieria,
5,
14-15.
News Item
163 - Soberon,X. (1999). Enzymes directly evolving toward commercial applications.
Nature Biotechnology,
17 (6),
539-540.
Nacional
164 - Oliver,G., Balbas,P., Valle,F., Soberon,X., Bolivar,F. (1985). [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].
Revista Latinoamericana de Microbiologia,
27 (2),
141-150.
165 - Soberon Mainero, Francisco Xavier (1982). Uso de vehiculos moleculares de clonacion y de sintesis quimica de polinucleotidos para el estadio de la expresion genica.
Instituto de Investigaciones Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Itakura, Keiichi, Bolivar Zapata, Francisco
Artículo
166 - Oropeza-Valdez,J.J., Padron-Manrique,C., Arellano-Villavicencio,J.E., Vazquez-Jimenez,A., Hernandez-Juarez,L.E., Soberon,X., Reyes-Escogido,M.L., Guardado-Mendoza,R., Resendis-Antonio,O.. Digital modeling of metformin and diet interactions on gut-microbiota metabolism in prediabetic patients.
Computational and Structural Biotechnology Journal,
31,
250-262.
Artículo
167 - Alvarado-Pena,N., Munoz-Torrico,M., Narvaez-Diaz,L., Mejia-Ponce,P.M, Becerril-Vargas,E., Zuniga,J., Muniz-Salazar,R., Laniado-Laborin,R., Licona-Cassani,C., Soberon,X., Silva-Herzog,E.. Mycobacterium tuberculosis genomic surveillance in Mexico. Characterization of variants in drug resistance and efflux pump genes.
Frontiers in Microbiology,
16,
1666838.
Artículo
168 - Anwar,S., Lamaudiere,M., Hassall,J., Dehinsilu,J., Bhuller,R.K., Hold,G.L., VAzquez-Campos,X., Mahnert,A., Moissl-Eichinger,C., Galle,B., Kainz,G., Pjevac,P., Hausmann,B., Schwarz,J., Kohl,G., Berry,D., Vancuren,S.J., len-Vercoe,E., Nielsen,N., Sorensen,N., Eklund,A., Nielsen,H.B., Riedel,R., Krause,J.L., Chang,H.-D., Park,S., Song,H.-Y., Seo,H., Ul-Haq,A., Kim,S., Kwon,Y., Park,S., Soberon,X., Silva-Herzog,E., Verlouw,J.A.M., Arp,P., Jhamai,M., Kraaij,R., Geelen,A.R., Ducarmon,Q.R., Smits,W.K., Kuijper,E.J., Zwittink,R.D., van,Best N., Penders,J., Le,G., Driessen,C., Kool,J., Shetty,S.A., Fuentes,S., Demirci,M., Yigin,A., Whalley,C., Beggs,A.D., Quince,C., James,R., Raguideau,S., Gordon,M., Mate,R., Fritzsche,M., Danckert,N.P., Blanco,J.M., Marchesi,J.R., Rauch,M., Williamson,R.A., Van't Wout,A.B., Kritz,A., Rosecker,S., Stevens,R., Laws,L., Sayavedra,L., Romano,S., Telatin,A., Baker,D., Narbad,A., Servetas,S.L., Kralj,J.G., Forry,S.P., Hunter,M.E., Dootz,J.N., Jackson,S.A., Mason,C.E., Butler,D.J., Mozsary,C., Foox,J., Damle,N., Resh,A., Busswitz,A., Lenz,P., Sontag,S., Cross,A., Sanchez,C., Guo,M., Olson,K., Smith,E.A., La Reau,A.J., Ward,T., Kuersten,S., Hyde,F., Khrebtukova,I., Schroth,G., Rijpkema,S., Amos,G.C.A., Sergaki,C.. DNA reference reagents isolate biases in microbiome profiling: a global multi-lab study.
mSystems,
10 (11),
e00466-25.
Artículo
169 - Arevalo-Salina,E.L., Nishigaki,T., Olvera,L., Gonzalez-Andrade,M., Xolalpa-Villanueva,W., Lopez-Romero,E.O., Soberon,X., Saab-Rincon,G.. Change in selectivity of estrogen receptor alpha ligand-binding domain by mutations at residues H524/L525.
Biochimica et Biophysica Acta.General Subjects,
1869 (4),
130775.
Artículo
170 - Tobon,E., Riano-Umbarila,L., Flores,H., Gutierrez,M., Soberon,X., Becerril-Lujan,B., Ramirez,O.T., Rudino-Pinera,E.. Functional expression of five refolded recombinant variants of RBD from SARS-CoV-2 in Escherichia coli.
Protein Expression and Purification,
235,
106781.
Artículo
171 - Galeana-Cadena,D., Ramirez-Martinez,G., Choreno-Parra,J.A., Silva-Herzog,E., Hernandez-Cardenas,C.M., Soberon,X., Zuniga,J.. Microbiome in the Nasopharynx: Insights into the Impact of COVID-19 Severity.
Heliyon,
10 (10),
e31562.
Artículo
172 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O.. Exploring metabolic anomalies in COVID-19 and post-COVID-19: a machine learning approach with explainable artificial intelligence.
Frontiers in Molecular Biosciences,
11,
1429281.
Artículo
173 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X. Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Preprint
174 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O.. Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence.
bioRxiv,
Preprint posted April 17,
2024.
Revisión
175 - Alvarado-Pena,N., Galeana-Cadena,D., Gomez-Garcia,I.A, Soberon-Mainero,X, Silva-Herzog,E. The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment.
Frontiers in Microbiology,
14,
1237998.
Nacional divulgacion
176 - Soberon-Mainero,X.. La Ingeniería Genética: una muy poderosa técnica, definidora de una carrera científica.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
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Artículo
177 - Barbosa-Amezcua,M., Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Carrillo-Sanchez,K., Mata-Rocha,M., Munoz-Torrico,M., Backer,C., Gonzalez-Covarrubias,V., Alaez-Verson,C., Soberon,X.. Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Microbiology Spectrum,
10 (5),
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Artículo
178 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Juarez-Rojop,I.E., Tovilla-Zarate,C.A., Soberon,X., Lanzagorta,N., Nicolini,H.. Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.
Brazilian Journal of Psychiatry,
44 (2),
164-170.
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Artículo
179 - Aguilar-Ordonez,I., Perez-Villatoro,F., Garcia-Ortiz,H., Barajas-Olmos,F., Ballesteros-Villascan,J., Gonzalez-Buenfil,R., Fresno,C., Garciarrubio,A., Fernandez-Lopez,J.C., Tovar,H., Hernandez-Lemus,E., Orozco,L., Soberon,X., Morett,E.. Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.
PLoS ONE,
16 (4),
e0249773,
[correction May 25 2022].
artículo
180 - Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Barbosa-Amezcua,M., Mata-Rocha,M., Munoz-Torrico,M., Salazar-Lezama,M.A., Martinez-Orozco,J.A., Narvaez-Diaz,L.A., Salas-Hernandez,J., Gonzalez-Covarrubias,V., Soberon,X.. A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.
PLoS ONE,
16 (10),
e0258774.
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Artículo
181 - Gonzalez-Covarrubias,V,, Sanchez-Ibarra,H., Lozano-Gonzalez, K., Villicana, S., Texis,T., Rodriguez-Dorantes,M., Cortes-Ramirez,S., Lavalle-Gonzalez,F,, Soberon,X., Barrera-Saldana,H.. Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.
Pharmacology,
106 (11-12),
588-596.
Artículo
182 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P.. Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
162[comentario vol 162 (9) pp 1-2] (8).
Artículo
183 - Valdez-Palomares,F., Munoz-Torrico,M., Palacios-Gonzalez,B., Soberon,X., Silva-Herzog,E.. Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers.
Microorganisms,
9 (8),
1762.
Revisión
184 - Gonzalez-Covarrubias,V., Lozano,K., Texis,T., Guzman-Cruz,C.K., Rodriguez-Dorantes,M., Rubio-Carrasco,K., Mendez-Lorenzo,L.H., Soberon,X.. Pharmacogenomics: Current Actionable Variants.
Revista de Investigacion Clinica,
73 (3).
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Artículo
185 - Cabrera-Contreras,R., Santamaria,R.I., Bustos,P., Martinez-Flores,I., Melendez-Herrada,E., Morelos-Ramirez,R., Barbosa-Amezcua,M., Gonzalez-Covarrubias,V., Silva-Herzog,E., Soberon,X., Gonzalez,V.. Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey.
PeerJ,
7,
e8068.
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Artículo
186 - Flannick,J., Mercader,J.M., Fuchsberger,C., Udler,M.S., Mahajan,A., Wessel,J., Teslovich,T.M., Caulkins,L., Koesterer,R., Barajas-Olmos,F., Blackwell,T.W., Boerwinkle,E., Brody,J.A., Centeno-Cruz,F., Chen,L., Chen,S., Contreras-Cubas,C., Cordova,E., Correa,A., Cortes,M., Defronzo,R.A., Dolan,L., Drews,K.L., Elliott,A., Floyd,J.S., Gabriel,S., Garay-Sevilla,M.E., Garcia-Ortiz,H., Gross,M., Han,S., Heard-Costa,N.L., Jackson,A.U., Jorgensen,M.E., Kang,H.M., Kelsey,M., Kim,B.J., Koistinen,H.A., Kuusisto,J., Leader,J.B., Linneberg,A., Liu,C.T., Liu,J., Lyssenko,V., Manning,A.K., Marcketta,A., Malacara-Hernandez,J.M., Martinez-Hernandez,A., Matsuo,K., Mayer-Davis,E., Mendoza-Caamal,E., Mohlke,K.L., Morrison,A.C., Ndungu,A., Ng,M.C.Y., O'Dushlaine,C., Payne,A.J., Pihoker,C., Post,W.S., Preuss,M., Psaty,B.M., Vasan,R.S., Rayner,N.W., Reiner,A.P., Revilla-Monsalve,C., Robertson,N.R., Santoro,N., Schurmann,C., So,W.Y., Soberon,X., Stringham,H.M., Strom,T.M., Tam,C.H.T., Thameem,F., Tomlinson,B., Torres,J.M., Tracy,R.P., van Dam,R.M., Vujkovic,M., Wang,S., Welch,R.P., Witte,D.R., Wong,T.Y., Atzmon,G., Barzilai,N., Blangero,J., Bonnycastle,L.L., Bowden,D.W., Chambers,J.C., Chan,E., Cheng,C.Y., Cho,Y.S., Collins,F.S., de Vries,P.S., Duggirala,R., Glaser,B., Gonzalez,C., Gonzalez,M.E., Groop,L., Kooner,J.S., Kwak,S.H., Laakso,M., Lehman,D.M., Nilsson,P., Spector,T.D., Tai,E.S., Tuomi,T., Tuomilehto,J., Wilson,J.G., guilar-Salinas,C.A., Bottinger,E., Burke,B., Carey,D.J., Chan,J.C.N., Dupuis,J., Frossard,P., Heckbert,S.R., Hwang,M.Y., Kim,Y.J., Kirchner,H.L., Lee,J.Y., Lee,J., Loos,R.J.F., Ma,R.C.W., Morris,A.D., O'Donnell,C.J., Palmer,C.N.A., Pankow,J., Park,K.S., Rasheed,A., Saleheen,D., Sim,X., Small,K.S., Teo,Y.Y., Haiman,C., Hanis,C.L., Henderson,B.E., Orozco,L., Tusie-Luna,T., Dewey,F.E., Baras,A., Gieger,C., Meitinger,T., Strauch,K., Lange,L., Grarup,N., Hansen,T., Pedersen,O., Zeitler,P., Dabelea,D., Abecasis,G., Bell,G.I., Cox,N.J., Seielstad,M., Sladek,R., Meigs,J.B., Rich,S.S., Rotter,J.I., Altshuler,D., Burtt,N.P., Scott,L.J., Morris,A.P., Florez,J.C., McCarthy,M.I., Boehnke,M.. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature,
570 (7759),
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187 - Gonzalez-Covarrubias,V., Morales-Franco,M., Cruz-Correa,O.F., Martinez-Hernandez,A., Garcia-Ortiz,H., Barajas-Olmos,F., Genis-Mendoza,A.D., Martinez-Magana,J.J., Nicolini,H., Orozco,L., Soberon,X.. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.
Frontiers in Pharmacology,
10,
1169.
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Artículo
188 - Madrazo-Moya,C.F., Cancino-Munoz,I., Cuevas-Cordoba,B., Gonzalez-Covarrubias,V., Barbosa-Amezcua,M., Soberon,X., Muniz-Salazar,R., Martinez-Guarneros,A., Backer,C., Zarrabal-Meza,J., Sampieri-Ramirez,C., Enciso-Moreno,A., Lauzardo,M., Comas,I., Zenteno-Cuevas,R.. Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
PLoS ONE,
14 (6),
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208 - Navarrete-Perea,J., Toledano-Magana,Y., Torre,P., Sciutto,E., Bobes,R.J., Soberon,X., Laclette,J.P.. Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis.
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1677-1683.
Artículo
240 - Moreno,A., Saab-Rincon,G., Santamaria,R.I., Soberon,X., Lopez-Munguia,A.. A more efficient starch degradation by the combination of hydrolase and transferase activities of alpha-amylase and cyclomaltodextrin glucanotransferase.
Starch-Starke,
56 (2),
63-68.
Artículo
241 - Osuna,J., Yanez,J., Soberon,X., Gaytan,P.. Protein evolution by codon-based random deletions.
Nucleic Acids Research,
32 (17),
e136.
Artículo
242 - Soberon,X., Fuentes-Gallego,P., Saab-Rincon,G.. In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.
FEBS Letters,
560 (1-3),
167-172.
Artículo
243 - Yanez,J., Arguello,M., Osuna,J., Soberon,X., Gaytan,P.. Combinatorial codon-based amino acid substitutions.
Nucleic Acids Research,
32 (20),
e158.
Nacional
244 - Soberon,X., Montero,G.M.. Ingeniería de proteínas y evolución dirigida. Fundamentos y casos exitosos de la biotecnologia moderna cap 7.
195-217,
Mexico.
Nacional
245 - Yanez,J., Soberon,X., Gaytan,P.. Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos.
Revista de la Sociedad Química de México,
48 (1),
26-37.
Artículo
246 - Rivera,M.H., Lopez-Munguia,A., Soberon,X., Saab-Rincon,G.. alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.
Protein Engineering,
16 (7),
505-514.
Nacional
247 - Soberon,X.. Biocatálisis y evolución dirigida de proteínas. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.
35-45,
Mexico,D.F..
Nacional
Divulgación
249 - Soberon Mainero,X. Veinte años del Instituto de Biotecnología.
Revista Universidad de Mexico,
629.
Artículo
250 - Gaytan,P., Osuna,J., Soberon,X.. Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.
Nucleic Acids Research,
30 (16),
e84-e84.
Artículo
251 - Osuna,J., Perez-Blancas,A., Soberon,X.. Improving a circularly permuted TEM-1 beta-lactamase by directed evolution.
Protein Engineering,
15 (6),
463-470.
Memoria in extenso
252 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A.. Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Divulgación
253 - Soberon Mainero, X.. La revolución de las ciencias genómicas.
Revista Universidad Nacional,
617.
Divulgación
254 - Soberon-Mainero,X.. La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia.
Mensaje Bioquimico,
26,
1-18.
Artículo
255 - Gaytan,P., Yanez,J., Sanchez,F., Soberon,X.. Orthogonal combinatorial mutagenesis: a codon-level combinatorial mutagenesis method useful for low multiplicity and amino acid-scanning protocols.
Nucleic Acids Research,
29 (3),
E9.
Artículo
256 - Saab-Rincon,G., Juarez,V.R., Osuna,J., Sanchez,F., Soberon,X.. Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution.
Protein Engineering,
14 (3),
149-155.
Nacional
257 - Soberon,X., Bolivar,F.. Evolución de los conceptos de gen y genoma. Ciencias de la vida.
61-83.
Divulgación
258 - Soberon,X.. Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales.
Revista Universidad de Mexico,
605-606,
59-63.
Divulgación
259 - Soberon,X.. El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.
BioTecnologia. Sociedad Mexicana de Biotecnologia y Bioingenieria,
5,
14-15.
Artículo
260 - Moreno-Hagelsieb,G., Gomez-Puyou,A., Soberon,X.. Escherichia coli TEM1 beta-lactamase in CTAB reverse micelles: exchange/diffusion-limited catalysis.
FEBS Letters,
459 (1),
111-114.
Artículo
261 - Saab-Rincon,G., Del Rio,G., Santamaria,R.I., Lopez-Munguia,A., Soberon,X.. Introducing transglycosylation activity in a liquefying alpha-amylase.
FEBS Letters,
453 (1-2),
100-106.
Artículo
262 - Santamaria,R.I., Del Rio,G., Saab,G., Rodriguez,M.E., Soberon,X., Lopez-Manguia,A.. Alcoholysis reactions from starch with alpha-amylases.
FEBS Letters,
452 (3),
346-350.
News Item
263 - Soberon,X.. Enzymes directly evolving toward commercial applications.
Nature Biotechnology,
17 (6),
539-540.
Artículo
264 - Galindo,E., Lagunas,F., Osuna,J., Soberon,X., Garcia,J.L.. A microbial biosensor for 6-aminopenicillanic acid.
Enzyme and Microbial Technology,
23 (5),
331-334.
Artículo
265 - Garcia,J.L., Nunez,C.J., Gonzalez,E.G., Osuna,J., Soberon,X., Galindo,E.. Microbial sensor for new-generation cephalosporins based in a protein-engineered beta-lactamase.
Applied Biochemistry and Biotechnology,
73 (2-3),
243-256.
Artículo
266 - Gaytan,P., Yanez,J., Sanchez,F., Mackie,H., Soberon,X.. Combination of DMT-mononucleotide and Fmoc-trinucleotide phosphoramidites in oligonucleotide synthesis affords an automatable codon-level mutagenesis method.
Chemistry and Biology,
5 (9),
519-527.
Artículo
267 - Gonzalez,V., Olvera,L., Soberon,X., Morett,E.. In vivo studies on the positive control function of NifA: a conserved hydrophobic amino acid patch at the central domain involved in transcriptional activation.
Molecular Microbiology,
28 (1),
55-67.
Artículo
268 - Del Rio,G., Morett,E., Soberon,X.. Did cyclodextrin glycosyltransferases evolve from alpha-amylases?.
FEBS Letters,
416 (2),
221-224.
Artículo
269 - Flores,H., Soberon,X., Sanchez,J., Bravo,A.. Isolated domain II and III from the Bacillus thuringiensis Cry1Ab delta-endotoxin binds to lepidopteran midgut membranes.
FEBS Letters,
414 (2),
313-318.
Artículo
270 - Gaytan,P., Yanez,J., Soberon,X., Martinez,R.. A new method for oligonucleotide derivatization of the 3' or 5'-termini with a CPG-support carrying the natural product isoargentatin-D.
Tetrahedron Letters,
38 (35),
6123-6126.
Artículo
271 - Muir,R.S., Flores,H., Zinder,N.D., Model,P., Soberon,X., Heitman,J.. Temperature-sensitive mutants of the EcoRI endonuclease.
Journal of Molecular Biology,
274 (5),
722-737.
Artículo
272 - Osuna,J., Soberon,X., Morett,E.. A proposed architecture for the central domain of the bacterial enhancer-binding proteins based on secondary structure prediction and fold recognition.
Protein Science,
6 (3),
543-555.
Artículo
273 - Del Rio,G., Lopez-Munguia,A., Soberon,X.. An engineered penicillin acylase with altered surface charge is more stable in alkaline pH.
Annals of the New York Academy of Sciences,
799,
61-64.
Artículo
274 - Moreno-Hagelsieb,G., Soberon,X.. Protein engineering as a powerful tool for the chemical modification of enzymes.
Biological Research,
29 (1),
127-140.
Artículo
275 - Del Rio,G., Rodriguez,M.E., Munguia,M.E., Lopez-Munguia,A., Soberon,X.. Mutant Escherichia coli penicillin acylase with enhanced stability at alkaline pH.
Biotechnology and Bioengineering,
48 (2),
141-148.
Artículo
276 - Flores,H., Osuna,J., Heitman,J., Soberon,X.. Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants.
Gene,
157 (1-2),
295-301.
Artículo
277 - Osuna,J., Viadiu,H., Fink,A.L., Soberon,X.. Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.
Journal of Biological Chemistry,
270 (2),
775-780.
Artículo
278 - Viadiu,H., Osuna,J., Fink,A.L., Soberon,X.. A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
Journal of Biological Chemistry,
270 (2),
781-787.
Artículo
279 - Del Rio,G., Osuna,J., Soberon,X.. Combinatorial libraries of proteins: analysis of efficiency of mutagenesis techniques.
Biotechniques,
17 (6),
1132-1139.
Artículo
280 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D.. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Revisión
281 - Osuna,J., Flores,H., Soberon,X.. Microbial systems and directed evolution of protein activities.
Critical Reviews in Microbiology,
20 (2),
107-116.
Artículo
282 - Merino,E., Osuna,J., Bolivar,F., Soberon,X.. A general, PCR-based method for single or combinatorial oligonucleotide-directed mutagenesis on pUC/M13 vectors.
Biotechniques,
12 (4),
508-510.
Artículo
283 - Pereyra-Alferez,B., Bravo,A., Quintero,R., Soberon,X.. The delta-endotoxin protein family displays a hydrophobic motif that might be implicated in toxicity.
Molecular Microbiology,
6 (15),
2095-2098.
Artículo
284 - Lopez,S., Lopez,I., Romero,P., Mendez,E., Soberon,X., Arias,C.F.. Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein.
Journal of Virology,
65 (7),
3738-3745.
Artículo
Note
286 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L.. Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Artículo
287 - Pastor,N., Pinero,D., Valdes,A.M., Soberon,X.. Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation.
Molecular Microbiology,
4 (11),
1957-1965.
Internacional
288 - Balbas,P., Soberon,X., Bolivar,F., Rodriguez,R.L.. The plasmid, pBR322. Biotechnology (Reading, Mass.).
5-41,
10.
Artículo
289 - Balbas,P., Soberon,X., Merino,E., Zurita,M., Lomeli,H., Valle,F., FLORES,N., Bolivar,F.. Plasmid vector pBR322 and its special-purpose derivatives--a review.
Gene,
50 (1-3),
3-40.
Nacional
290 - Oliver,G., Balbas,P., Valle,F., Soberon,X., Bolivar,F.. [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].
Revista Latinoamericana de Microbiologia,
27 (2),
141-150.
Artículo
292 - Rossi,J.J., Soberon,X., Marumoto,Y., McMahon,J., Itakura,K.. Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.
Proceedings of the National Academy of Sciences of the United States of America,
80 (11),
3203-3207.
*
Artículo
293 - Inouye,S., Soberon,X., Franceschini,T., Nakamura,K., Itakura,K., Inouye,M.. Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
Proceedings of the National Academy of Sciences of the United States of America,
79 (11),
3438-3441 .
*
Artículo
294 - Miyada,C.G., Soberon,X., Itakura,K., Wilcox,G.. The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r.
Gene,
17 (2),
167-177.
*
Artículo
295 - Zarucki-Schulz,T., Tsai,S.Y., Itakura,K., Soberon,X., Wallace,R.B., Tsai,M.J., Woo,S.L., O'Malley,B.W.. Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription.
Journal of Biological Chemistry,
257 (18),
11070-11077.
*
296 - Soberon Mainero, Francisco Xavier. Uso de vehiculos moleculares de clonacion y de sintesis quimica de polinucleotidos para el estadio de la expresion genica.
Instituto de Investigaciones Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Itakura, Keiichi, Bolivar Zapata, Francisco
Artículo
297 - Covarrubias,L., Cervantes,L., Covarrubias,A., Soberon,X., Vichido,I., Blanco,A., Kupersztoch-Portnoy,Y.M., Bolivar,F.. Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328.
Gene,
13 (1),
25-35.
*
Artículo
298 - Soberon,X., Covarrubias,L., Bolivar,F.. Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.
Gene,
9 (3-4),
287-305.
*
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