Dra. Georgina Gurrola Briones
Investigador
Nivel B del PRIDE
Nivel II del SNI
Nivel II del SNI
Doctorado, en Investigacion Biomedica Basica, IBt-UNAM (1995)
Maestría, Bioquímica, Fac. de Química-UNAM (1986)
Licenciatura, Químico Farmaceutico Biologo, FES-Cuautitlan-UNAM (1979)
- Activos
- Graduados
-
Licenciatura
-
Estancia Temporal
-
Maestría.
1 - Vázquez Ramírez, José Noé (2021). Caracterización bioquímica de los componentes del veneno del alacrán Centruroides nigrescens.
Escuela de Estudios Superiores del Jicarero, Jojutla,
Licenciatura en Biología,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola Briones, Georgina
2 - Garcia Guerrero, Ivan Alberto (2018). Caracterizacion bioquimica del veneno del alacran Centruroides ornatus, una especie de interes medico .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
3 - Uribe Mendonza, Ivett (2015). Estudio de la interacción de la Imperatoxina A con el receptor de la Ryanodina por medio de ensayos de entrecruzamiento.
Facultad de Ciencias Biológicas ,
Bióloga,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola Briones, Georgina
4 - Sanchez Vasquez, Lorenzo (2011). Diseno de nuevos peptidos : sinteticos antimicrobianos.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
5 - Gomez Utrera, Dora Luz (2010). Identificacion de eventos moleculares asociados a la intoxicacion con la toxina Cn2 mediante electroforesis bidimensional .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
6 - Cazares Ordonez, Verna (2009). Busqueda y evaluacion de un marcador molecular para el estudio de los canales de potasio tipo hERG3 a partir del veneno del alacran Centruroides gracilis .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
7 - Hernández Aponte,Cynthia Annabel (2009). Búsqueda, identificación y caracterización de componentes de venenos de alacranes Mexicanos con actividad antibacteriana.
Centro de Investigación en Biotecnología ,
Maestro en Biotecnología,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola-Briones, Georgina
8 - Hernández Aponte,Cynthia Annabel (2007). Caracterización bioquímica de componentes de bajo peso molecular del veneno del alacrán Centruroides noxius Hoffmann.
Facultad de Ciencias Químicas e Ingeniería,
Ingeniero Químico,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola Briones, Georgina
9 - Espino Solis, Gerardo Pavel (2004). Desarrollo de un peptido sintetico capaz de inducir anticuerpos neutralizantes en contra del veneno del alacran Centruroides noxius Hoffmann.
Instituto de Biotecnologia,
Maestro en Ciencias (Bioquimica),
UNAM.
Asesor: Gurrola Briones, Georgina
10 - Chavira Suarez, Erika (2004). Estudio del uso de una vacuna de DNA, como un posible tratamiento en contra del envenenamiento por picadura de alacran.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Gurrola Briones, Georgina
11 - Pimienta Rosales, Genaro (2000). Aislamiento y caracterizacion de un peptido del veneno del alacran Centruroides noxiushoffmann, que bloquea especificamente el canal de potasio Herg.
Instituto de Biotecnologia,
Maestro en Ciencias (Bioquimica),
UNAM.
Asesor: Gurrola Briones, Georgina
Total de publicaciones: 68
- Tipo
- Fecha
Artículo
12 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G. (2022). sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochemical Pharmacology,
199,
115023.
Artículo
13 - Garcia-Guerrero,I.A., Carcamo-Noriega,E., Gomez-Lagunas,F., Gonzalez-Santillan,E., Zamudio,F.Z., Gurrola,G.B., Possani,L.D. (2020). Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans.
Toxicon,
173,
27-38.
Artículo
14 - Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., Possani, L. D. (2019). Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function.
Toxicon,
167,
184-191.
Artículo
Artículo
16 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H. (2016). Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.
Journal of General Physiology,
147 (5),
375-394.
Revisión
17 - Ortiz,E., Gurrola,G.B., Schwartz,E.F., Possani,L.D. (2015). Scorpion venom components as potential candidates for drug development.
Toxicon,
93,
125-135.
Artículo
18 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Powers,P.P., Willis,B.C., Moss,R.L., Jalife,J., Valdivia,H.H. (2015). Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.
Proceedings of the National Academy of Sciences of the United States of America,
112 (13),
E1669-E1677.
Revisión
19 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Hernandez,J.J., Valdivia,H.H. (2015). Arrhythmogenic mechanisms in ryanodine receptor channelopathies.
Science China Life Sciences,
58 (1),
54-58.
Revisión
20 - Quintero-Hernandez,V., Jimenez-Vargas,J.M., Gurrola,G.B., Valdivia,H.H., Possani,L.D. (2013). Scorpion venom components that affect ion-channels function.
Toxicon,
76,
328-342.
Artículo
21 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B. (2013). A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
22 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D. (2013). Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1830 (6),
3427-3436.
Artículo
23 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D. (2012). Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry,
51 (19),
4049-4061.
Artículo
24 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D. (2012). Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
25 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G. (2012). Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells.
Molecular Pharmacology,
82 (3),
372-382.
Artículo
26 - Hernandez-Aponte,C.A., Silva-Sanchez,J., Quintero-Hernandez,V., Rodriguez-Romero,A., Balderas,C., Possani,L.D., Gurrola,G.B. (2011). Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.
Toxicon,
57 (1),
84-92.
Artículo; Actas Paper
27 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Quintero-Hernandez,V., Gurrola,G.B., Possani,L.D. (2011). Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.
Peptides,
32 (3),
560-567.
Artículo
28 - Gurrola,G.B., Capes,E.M., Zamudio,F.Z., Possani,L.D., Valdivia,H.H. (2010). Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.
Pharmaceuticals.(Basel),
3 (4),
1093-1107.
Revisión
29 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D. (2009). Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells.
Toxicology Letters,
187 (1),
1-9.
Artículo
30 - Aparicio-Fabre,R., Guillen,G., Estrada,G., Olivares-Grajales,J., Gurrola,G., Sanchez,F. (2006). Profilin tyrosine phosphorylation in poly-l-proline-binding regions inhibits binding to phosphoinositide 3-kinase in Phaseolus vulgaris.
Plant Journal,
47 (4),
491-500.
Artículo; Actas Paper
31 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E. (2006). Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS.
Molecular Pharmacology,
69 (5),
1673-1683.
Artículo
32 - Schiavon,E., Sacco,T., Restano-Cassulini,R., Gurrola,G., Tempia,F., Possani,L.D., Wanke,E. (2006). Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons.
Journal of Biological Chemistry,
281 (29),
20326-20337.
Artículo
33 - Coronas,F.I., Balderas,C., Lopez,L.P., Possani,L.D., Gurrola,G.B. (2005). Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus.
Journal of the Brazilian Chemical Society,
16 (3A),
404-411.
Artículo
34 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M. (2004). Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels.
Proteins,
56 (2),
367-375.
Artículo
35 - Rosales-Castillo,J.A., Acosta-Saavedra,L.C., Torres,R., Ochoa-Fierro,J., Borja-Aburto,V.H., Lopez-Carrillo,L., Garcia-Vargas,G.G., Gurrola,G.B., Cebrian,M.E., Calderon-Aranda,E.S. (2004). Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study.
International Archives of Occupational and Environmental Health,
77 (6),
418-423.
Artículo
36 - Gazarian,T.G., Selisko,B., Gurrola,G.B., Possani,L.D., Gazarian,K.G. (2003). Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2.
Combinatorial Chemistry & High Throughput Screening,
6 (2),
119-132.
Artículo
37 - Corona,M., Gurrola,G.B., Merino,E., Cassulini,R.R., Valdez-Cruz,N.A., Garcia,B, Ramirez-Dominguez,M.E., Coronas,F.I., Zamudio,F.Z., Wanke,E., Possani,L.D. (2002). A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides.
FEBS Letters,
532 (1-2),
121-126.
Artículo
38 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E. (2002). Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Journal of Neuroscience,
22 (9),
3414-3425.
Artículo
39 - Pardo-Lopez,L., Garcia-Valdes,J., Gurrola,G.B., Robertson,G.A., Possani,L.D. (2002). Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Letters,
510 (1-2),
45-49.
Artículo
40 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G. (2001). Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells.
European Biophysics Journal,
29 (8),
569-573.
Artículo
41 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A. (2001). Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Journal of Physiology,
534 (Pt 3),
721-732.
Carta
42 - Bottiglieri,C., Ferrara,L., Corona,M., Gurrola,G.B., Batista,C., Wanke,E., Possani,L.D. (2000). Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel.
FEBS Letters,
479 (3),
156-157 .
Artículo
43 - Torres-Larios,A., Gurrola,G.B., Zamudio,F.Z., Possani,L.D. (2000). Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
European Journal of Biochemistry,
267 (16),
5023-5031.
Artículo
44 - Calderon-Aranda,E.S., Selisko,B., York,E.J., Gurrola,G.B., Stewart,J.M., Possani,L.D. (1999). Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
European Journal of Biochemistry,
264 (3),
746-755.
Artículo
45 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E. (1999). A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom.
FASEB Journal,
13 (8),
953-962.
Artículo
46 - Gurrola,G.B., Arevalo,C., Sreekumar,R., Lokuta,A.J., Walker,J.W., Valdivia,H.H. (1999). Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor.
Journal of Biological Chemistry,
274 (12),
7879-7886.
*
Revisión
47 - Possani,L.D., Selisko,B., Gurrola,G.B. (1999). Structure and function of scorpion toxins affecting K+-channels.
Perspectives In Drug Discovery And Design,
16,
15-40.
Artículo
48 - Samso,M., Trujillo,R., Gurrola,G.B., Valdivia,H.H., Wagenknecht,T. (1999). Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor.
Journal of Cell Biology,
146 (2),
493-499.
*
Artículo
49 - Zhu,X., Gurrola,G., Jiang,M.T., Walker,J.W., Valdivia,H.H. (1999). Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors.
FEBS Letters,
450 (3),
221-226.
*
Artículo
50 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B. (1998). Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Artículo
Artículo
52 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D. (1997). Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.
FEBS Letters,
405 (3),
385-389.
Artículo
53 - Dehesa-Davila,M., Ramirez,A.N., Zamudio,F.Z., Gurrola-Briones,G., Lievano,A., Darszon,A., Possani,L.D. (1996). Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
113 (2),
331-339.
Artículo
54 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D. (1996). Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
55 - Nieto,A.R., Gurrola,G.B., Vaca,L., Possani,L.D. (1996). Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
913-922.
Artículo
56 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D. (1996). A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
57 - Dauplais,M., Gilquin,B., Possani,L.D., Gurrola-Briones,G., Roumestand,C., Menez,A. (1995). Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins.
Biochemistry,
34 (51),
16563-16573.
Artículo
58 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C. (1995). Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.
Biochemical and Biophysical Research Communications,
213 (3),
901-907.
Artículo
59 - Gurrola,G.B., Possani,L.D. (1995). Structural and functional features of noxiustoxin: a K+ channel blocker.
Biochemistry and Molecular Biology International,
37 (3),
527-535.
Artículo
60 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D. (1995). Monoclonal antibodies against noxiustoxin.
Hybridoma,
14 (3),
247-251.
Artículo
61 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D. (1994). The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Artículo
62 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D. (1994). Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemical Journal,
304 (Pt 1),
51-56.
Artículo
63 - Ramirez,A.N., Martin,B.M., Gurrola,G.B., Possani,L.D. (1994). Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Toxicon,
32 (4),
479-490.
Artículo
64 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L. (1993). Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker.
Journal of Membrane Biology,
134 (2),
123-129.
Artículo
65 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M. (1992). Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels.
Toxicon,
30 (11),
1343-1364.
Artículo
66 - Zamudio,F., Saavedra,R., Martin,B.M., Gurrola-Briones,G., Herion,P., Possani,L.D. (1992). Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann.
European Journal of Biochemistry,
204 (1),
281-292.
Artículo
67 - Gurrola,G.B., Molinar-Rode,R., Sitges,M., Bayon,A., Possani,L.D. (1989). Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion.
Journal of Neural Transmission,
77 (1),
11-20.
Artículo
68 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D. (1988). Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
785-794.
Artículo
69 - Ramirez,A.N., Gurrola,G.B., Martin,B.M., Possani,L.D. (1988). Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
773-783.
Artículo
70 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D. (1987). Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.
Circulation Research,
61 (4 Pt 2),
I6-I9.
Internacional
71 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R. (2011). Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas .
147-180,
Mexico.
Internacional
72 - Gurrola,G.B., Zhu,X., Valdivia,H (2005). Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function. Ryanodine receptors : structure, function and dysfunction in clinical disease.
Developments in Cardiovascular Medicine,
191-200,
254,
New York.
Memoria in extenso
73 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D. (1991). Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America.
7 p,
Caracas.
Memoria in extenso
74 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E. (1991). Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Nacional
75 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D. (1984). Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos.
35-50.
Preprint
76 - Sheard,T.M.D., Howlett,L., Kirton,H., Yang,Z., Gurrola,G., Steele,D., Jayasinghe,I., Valdivia,H.H., Colyer,J. (2020). Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes.
bioRxiv,
Preprint posted June 28.
77 - Gurrola Briones, Georgina (1994). Caracterizacion funcional estructural de la noxiustoxina.
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Possani, Lourival Domingos
78 - Gurrola Briones, Georgina (1986). Sintesis quimica de peptidos correspondientes a secuencias de aminoacidos de toxinas de alacran y sus propiedades.
Instituto de Biotecnologia,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Possani, Lourival Domingos
79 - Gurrola Briones, Georgina (1981). Busqueda e identificacion de anticuerpos contra antigenos del sistema hla .
FES Cuautitlan,
Quimico Farmaceutico Biologo,
UNAM.
*
Asesor: Teran Ortiz, Luis Angel
Artículo
80 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G.. sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochemical Pharmacology,
199,
115023.
Artículo
81 - Garcia-Guerrero,I.A., Carcamo-Noriega,E., Gomez-Lagunas,F., Gonzalez-Santillan,E., Zamudio,F.Z., Gurrola,G.B., Possani,L.D.. Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans.
Toxicon,
173,
27-38.
Preprint
82 - Sheard,T.M.D., Howlett,L., Kirton,H., Yang,Z., Gurrola,G., Steele,D., Jayasinghe,I., Valdivia,H.H., Colyer,J.. Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes.
bioRxiv,
Preprint posted June 28.
Artículo
83 - Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., Possani, L. D.. Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function.
Toxicon,
167,
184-191.
Artículo
85 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H.. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.
Journal of General Physiology,
147 (5),
375-394.
Revisión
86 - Ortiz,E., Gurrola,G.B., Schwartz,E.F., Possani,L.D.. Scorpion venom components as potential candidates for drug development.
Toxicon,
93,
125-135.
Artículo
87 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Powers,P.P., Willis,B.C., Moss,R.L., Jalife,J., Valdivia,H.H.. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.
Proceedings of the National Academy of Sciences of the United States of America,
112 (13),
E1669-E1677.
Revisión
88 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Hernandez,J.J., Valdivia,H.H.. Arrhythmogenic mechanisms in ryanodine receptor channelopathies.
Science China Life Sciences,
58 (1),
54-58.
Revisión
89 - Quintero-Hernandez,V., Jimenez-Vargas,J.M., Gurrola,G.B., Valdivia,H.H., Possani,L.D.. Scorpion venom components that affect ion-channels function.
Toxicon,
76,
328-342.
Artículo
90 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B.. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
91 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D.. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1830 (6),
3427-3436.
Artículo
92 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D.. Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry,
51 (19),
4049-4061.
Artículo
93 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D.. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
94 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G.. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells.
Molecular Pharmacology,
82 (3),
372-382.
Artículo
95 - Hernandez-Aponte,C.A., Silva-Sanchez,J., Quintero-Hernandez,V., Rodriguez-Romero,A., Balderas,C., Possani,L.D., Gurrola,G.B.. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.
Toxicon,
57 (1),
84-92.
Artículo; Actas Paper
96 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Quintero-Hernandez,V., Gurrola,G.B., Possani,L.D.. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.
Peptides,
32 (3),
560-567.
Internacional
97 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R.. Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas .
147-180,
Mexico.
Artículo
98 - Gurrola,G.B., Capes,E.M., Zamudio,F.Z., Possani,L.D., Valdivia,H.H.. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.
Pharmaceuticals.(Basel),
3 (4),
1093-1107.
Revisión
99 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D.. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells.
Toxicology Letters,
187 (1),
1-9.
Artículo
100 - Aparicio-Fabre,R., Guillen,G., Estrada,G., Olivares-Grajales,J., Gurrola,G., Sanchez,F.. Profilin tyrosine phosphorylation in poly-l-proline-binding regions inhibits binding to phosphoinositide 3-kinase in Phaseolus vulgaris.
Plant Journal,
47 (4),
491-500.
Artículo; Actas Paper
101 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E.. Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS.
Molecular Pharmacology,
69 (5),
1673-1683.
Artículo
102 - Schiavon,E., Sacco,T., Restano-Cassulini,R., Gurrola,G., Tempia,F., Possani,L.D., Wanke,E.. Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons.
Journal of Biological Chemistry,
281 (29),
20326-20337.
Artículo
103 - Coronas,F.I., Balderas,C., Lopez,L.P., Possani,L.D., Gurrola,G.B.. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus.
Journal of the Brazilian Chemical Society,
16 (3A),
404-411.
Internacional
104 - Gurrola,G.B., Zhu,X., Valdivia,H. Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function. Ryanodine receptors : structure, function and dysfunction in clinical disease.
Developments in Cardiovascular Medicine,
191-200,
254,
New York.
Artículo
105 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M.. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels.
Proteins,
56 (2),
367-375.
Artículo
106 - Rosales-Castillo,J.A., Acosta-Saavedra,L.C., Torres,R., Ochoa-Fierro,J., Borja-Aburto,V.H., Lopez-Carrillo,L., Garcia-Vargas,G.G., Gurrola,G.B., Cebrian,M.E., Calderon-Aranda,E.S.. Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study.
International Archives of Occupational and Environmental Health,
77 (6),
418-423.
Artículo
107 - Gazarian,T.G., Selisko,B., Gurrola,G.B., Possani,L.D., Gazarian,K.G.. Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2.
Combinatorial Chemistry & High Throughput Screening,
6 (2),
119-132.
Artículo
108 - Corona,M., Gurrola,G.B., Merino,E., Cassulini,R.R., Valdez-Cruz,N.A., Garcia,B, Ramirez-Dominguez,M.E., Coronas,F.I., Zamudio,F.Z., Wanke,E., Possani,L.D.. A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides.
FEBS Letters,
532 (1-2),
121-126.
Artículo
109 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E.. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Journal of Neuroscience,
22 (9),
3414-3425.
Artículo
110 - Pardo-Lopez,L., Garcia-Valdes,J., Gurrola,G.B., Robertson,G.A., Possani,L.D.. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Letters,
510 (1-2),
45-49.
Artículo
111 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G.. Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells.
European Biophysics Journal,
29 (8),
569-573.
Artículo
112 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A.. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Journal of Physiology,
534 (Pt 3),
721-732.
Carta
113 - Bottiglieri,C., Ferrara,L., Corona,M., Gurrola,G.B., Batista,C., Wanke,E., Possani,L.D.. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel.
FEBS Letters,
479 (3),
156-157 .
Artículo
114 - Torres-Larios,A., Gurrola,G.B., Zamudio,F.Z., Possani,L.D.. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
European Journal of Biochemistry,
267 (16),
5023-5031.
Artículo
115 - Calderon-Aranda,E.S., Selisko,B., York,E.J., Gurrola,G.B., Stewart,J.M., Possani,L.D.. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
European Journal of Biochemistry,
264 (3),
746-755.
Artículo
116 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E.. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom.
FASEB Journal,
13 (8),
953-962.
Artículo
117 - Gurrola,G.B., Arevalo,C., Sreekumar,R., Lokuta,A.J., Walker,J.W., Valdivia,H.H.. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor.
Journal of Biological Chemistry,
274 (12),
7879-7886.
*
Revisión
118 - Possani,L.D., Selisko,B., Gurrola,G.B.. Structure and function of scorpion toxins affecting K+-channels.
Perspectives In Drug Discovery And Design,
16,
15-40.
Artículo
119 - Samso,M., Trujillo,R., Gurrola,G.B., Valdivia,H.H., Wagenknecht,T.. Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor.
Journal of Cell Biology,
146 (2),
493-499.
*
Artículo
120 - Zhu,X., Gurrola,G., Jiang,M.T., Walker,J.W., Valdivia,H.H.. Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors.
FEBS Letters,
450 (3),
221-226.
*
Artículo
121 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B.. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Artículo
Artículo
123 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D.. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.
FEBS Letters,
405 (3),
385-389.
Artículo
124 - Dehesa-Davila,M., Ramirez,A.N., Zamudio,F.Z., Gurrola-Briones,G., Lievano,A., Darszon,A., Possani,L.D.. Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
113 (2),
331-339.
Artículo
125 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D.. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
126 - Nieto,A.R., Gurrola,G.B., Vaca,L., Possani,L.D.. Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
913-922.
Artículo
127 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D.. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
128 - Dauplais,M., Gilquin,B., Possani,L.D., Gurrola-Briones,G., Roumestand,C., Menez,A.. Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins.
Biochemistry,
34 (51),
16563-16573.
Artículo
129 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C.. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.
Biochemical and Biophysical Research Communications,
213 (3),
901-907.
Artículo
130 - Gurrola,G.B., Possani,L.D.. Structural and functional features of noxiustoxin: a K+ channel blocker.
Biochemistry and Molecular Biology International,
37 (3),
527-535.
Artículo
131 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D.. Monoclonal antibodies against noxiustoxin.
Hybridoma,
14 (3),
247-251.
Artículo
132 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D.. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Artículo
133 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D.. Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemical Journal,
304 (Pt 1),
51-56.
Artículo
134 - Ramirez,A.N., Martin,B.M., Gurrola,G.B., Possani,L.D.. Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Toxicon,
32 (4),
479-490.
135 - Gurrola Briones, Georgina. Caracterizacion funcional estructural de la noxiustoxina.
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Teran Ortiz, Luis Angel
Artículo
136 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L.. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker.
Journal of Membrane Biology,
134 (2),
123-129.
Artículo
137 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M.. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels.
Toxicon,
30 (11),
1343-1364.
Artículo
138 - Zamudio,F., Saavedra,R., Martin,B.M., Gurrola-Briones,G., Herion,P., Possani,L.D.. Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann.
European Journal of Biochemistry,
204 (1),
281-292.
Memoria in extenso
139 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D.. Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America.
7 p,
Caracas.
Memoria in extenso
140 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E.. Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Artículo
141 - Gurrola,G.B., Molinar-Rode,R., Sitges,M., Bayon,A., Possani,L.D.. Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion.
Journal of Neural Transmission,
77 (1),
11-20.
Artículo
142 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D.. Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
785-794.
Artículo
143 - Ramirez,A.N., Gurrola,G.B., Martin,B.M., Possani,L.D.. Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
773-783.
Artículo
144 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D.. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.
Circulation Research,
61 (4 Pt 2),
I6-I9.
145 - Gurrola Briones, Georgina. Sintesis quimica de peptidos correspondientes a secuencias de aminoacidos de toxinas de alacran y sus propiedades.
Instituto de Biotecnologia,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Teran Ortiz, Luis Angel
Nacional
146 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D.. Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos.
35-50.
147 - Gurrola Briones, Georgina. Busqueda e identificacion de anticuerpos contra antigenos del sistema hla .
FES Cuautitlan,
Quimico Farmaceutico Biologo,
UNAM.
*
Asesor: Teran Ortiz, Luis Angel