Dra. Georgina Gurrola Briones
Investigador
Nivel B del PRIDE
Nivel II del SNI
Nivel II del SNI
Doctorado, en Investigacion Biomedica Basica, IBt-UNAM (1995)
Maestría, Bioquímica, Fac. de Química-UNAM (1986)
Licenciatura, Químico Farmaceutico Biologo, FES-Cuautitlan-UNAM (1979)
- Activos
- Graduados
-
Maestría
-
Licenciatura
-
Estancia Temporal
1 - Vázquez Ramírez, José Noé (2021). Caracterización bioquímica de los componentes del veneno del alacrán Centruroides nigrescens.
Escuela de Estudios Superiores del Jicarero, Jojutla,
Licenciatura en Biología,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola Briones, Georgina
2 - Garcia Guerrero, Ivan Alberto (2018). Caracterizacion bioquimica del veneno del alacran Centruroides ornatus, una especie de interes medico .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
3 - Uribe Mendonza, Ivett (2015). Estudio de la interacción de la Imperatoxina A con el receptor de la Ryanodina por medio de ensayos de entrecruzamiento.
Facultad de Ciencias Biológicas ,
Bióloga,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola Briones, Georgina
4 - Sanchez Vasquez, Lorenzo (2011). Diseno de nuevos peptidos : sinteticos antimicrobianos.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
5 - Gomez Utrera, Dora Luz (2010). Identificacion de eventos moleculares asociados a la intoxicacion con la toxina Cn2 mediante electroforesis bidimensional .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
6 - Cazares Ordonez, Verna (2009). Busqueda y evaluacion de un marcador molecular para el estudio de los canales de potasio tipo hERG3 a partir del veneno del alacran Centruroides gracilis .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gurrola Briones, Georgina
7 - Hernández Aponte,Cynthia Annabel (2009). Búsqueda, identificación y caracterización de componentes de venenos de alacranes Mexicanos con actividad antibacteriana.
Centro de Investigación en Biotecnología ,
Maestro en Biotecnología,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola-Briones, Georgina
8 - Hernández Aponte,Cynthia Annabel (2007). Caracterización bioquímica de componentes de bajo peso molecular del veneno del alacrán Centruroides noxius Hoffmann.
Facultad de Ciencias Químicas e Ingeniería,
Ingeniero Químico,
Universidad Autónoma del Estado de Morelos.
*
Asesor: Gurrola Briones, Georgina
9 - Espino Solis, Gerardo Pavel (2004). Desarrollo de un peptido sintetico capaz de inducir anticuerpos neutralizantes en contra del veneno del alacran Centruroides noxius Hoffmann.
Instituto de Biotecnologia,
Maestro en Ciencias (Bioquimica),
UNAM.
Asesor: Gurrola Briones, Georgina
10 - Chavira Suarez, Erika (2004). Estudio del uso de una vacuna de DNA, como un posible tratamiento en contra del envenenamiento por picadura de alacran.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Gurrola Briones, Georgina
11 - Pimienta Rosales, Genaro (2000). Aislamiento y caracterizacion de un peptido del veneno del alacran Centruroides noxiushoffmann, que bloquea especificamente el canal de potasio Herg.
Instituto de Biotecnologia,
Maestro en Ciencias (Bioquimica),
UNAM.
Asesor: Gurrola Briones, Georgina
Total de publicaciones: 70
- Tipo
- Fecha
Artículo
12 - Haji-Ghassemi,O., Chen,Y.S., Woll,K., Gurrola,G.B., Valdivia,C.R., Cai,W., Li,S., Valdivia,H.H., Van Petegem,F. (2023). Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation.
Science Advances,
9 (21),
eadf4936.
Artículo
13 - Naseem,M.U., Gurrola-Briones,G., Romero-Imbachi,M.R., Borrego,J., Carcamo-Noriega,E., Beltran-Vidal,J., Zamudio,F.Z., Shakeel,K., Possani,L.D., Panyi,G. (2023). Characterization and Chemical Synthesis of Cm39 (à-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1.
Toxins (Basel),
15 (1),
41.
Artículo
14 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G. (2022). sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochemical Pharmacology,
199,
115023.
Artículo
15 - Garcia-Guerrero,I.A., Carcamo-Noriega,E., Gomez-Lagunas,F., Gonzalez-Santillan,E., Zamudio,F.Z., Gurrola,G.B., Possani,L.D. (2020). Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans.
Toxicon,
173,
27-38.
Artículo
16 - Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., Possani, L. D. (2019). Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function.
Toxicon,
167,
184-191.
Artículo
Artículo
18 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H. (2016). Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.
Journal of General Physiology,
147 (5),
375-394.
Revisión
19 - Ortiz,E., Gurrola,G.B., Schwartz,E.F., Possani,L.D. (2015). Scorpion venom components as potential candidates for drug development.
Toxicon,
93,
125-135.
Artículo
20 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Powers,P.P., Willis,B.C., Moss,R.L., Jalife,J., Valdivia,H.H. (2015). Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.
Proceedings of the National Academy of Sciences of the United States of America,
112 (13),
E1669-E1677.
Revisión
21 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Hernandez,J.J., Valdivia,H.H. (2015). Arrhythmogenic mechanisms in ryanodine receptor channelopathies.
Science China Life Sciences,
58 (1),
54-58.
Revisión
22 - Quintero-Hernandez,V., Jimenez-Vargas,J.M., Gurrola,G.B., Valdivia,H.H., Possani,L.D. (2013). Scorpion venom components that affect ion-channels function.
Toxicon,
76,
328-342.
Artículo
23 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B. (2013). A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
24 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D. (2013). Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1830 (6),
3427-3436.
Artículo
25 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D. (2012). Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry,
51 (19),
4049-4061.
Artículo
26 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D. (2012). Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
27 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G. (2012). Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells.
Molecular Pharmacology,
82 (3),
372-382.
Artículo
28 - Hernandez-Aponte,C.A., Silva-Sanchez,J., Quintero-Hernandez,V., Rodriguez-Romero,A., Balderas,C., Possani,L.D., Gurrola,G.B. (2011). Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.
Toxicon,
57 (1),
84-92.
Artículo; Actas Paper
29 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Quintero-Hernandez,V., Gurrola,G.B., Possani,L.D. (2011). Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.
Peptides,
32 (3),
560-567.
Artículo
30 - Gurrola,G.B., Capes,E.M., Zamudio,F.Z., Possani,L.D., Valdivia,H.H. (2010). Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.
Pharmaceuticals.(Basel),
3 (4),
1093-1107.
Revisión
31 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D. (2009). Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells.
Toxicology Letters,
187 (1),
1-9.
Artículo
32 - Aparicio-Fabre,R., Guillen,G., Estrada,G., Olivares-Grajales,J., Gurrola,G., Sanchez,F. (2006). Profilin tyrosine phosphorylation in poly-l-proline-binding regions inhibits binding to phosphoinositide 3-kinase in Phaseolus vulgaris.
Plant Journal,
47 (4),
491-500.
Artículo; Actas Paper
33 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E. (2006). Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS.
Molecular Pharmacology,
69 (5),
1673-1683.
Artículo
34 - Schiavon,E., Sacco,T., Restano-Cassulini,R., Gurrola,G., Tempia,F., Possani,L.D., Wanke,E. (2006). Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons.
Journal of Biological Chemistry,
281 (29),
20326-20337.
Artículo
35 - Coronas,F.I., Balderas,C., Lopez,L.P., Possani,L.D., Gurrola,G.B. (2005). Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus.
Journal of the Brazilian Chemical Society,
16 (3A),
404-411.
Artículo
36 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M. (2004). Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels.
Proteins,
56 (2),
367-375.
Artículo
37 - Rosales-Castillo,J.A., Acosta-Saavedra,L.C., Torres,R., Ochoa-Fierro,J., Borja-Aburto,V.H., Lopez-Carrillo,L., Garcia-Vargas,G.G., Gurrola,G.B., Cebrian,M.E., Calderon-Aranda,E.S. (2004). Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study.
International Archives of Occupational and Environmental Health,
77 (6),
418-423.
Artículo
38 - Gazarian,T.G., Selisko,B., Gurrola,G.B., Possani,L.D., Gazarian,K.G. (2003). Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2.
Combinatorial Chemistry & High Throughput Screening,
6 (2),
119-132.
Artículo
39 - Corona,M., Gurrola,G.B., Merino,E., Cassulini,R.R., Valdez-Cruz,N.A., Garcia,B, Ramirez-Dominguez,M.E., Coronas,F.I., Zamudio,F.Z., Wanke,E., Possani,L.D. (2002). A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides.
FEBS Letters,
532 (1-2),
121-126.
Artículo
40 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E. (2002). Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Journal of Neuroscience,
22 (9),
3414-3425.
Artículo
41 - Pardo-Lopez,L., Garcia-Valdes,J., Gurrola,G.B., Robertson,G.A., Possani,L.D. (2002). Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Letters,
510 (1-2),
45-49.
Artículo
42 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G. (2001). Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells.
European Biophysics Journal,
29 (8),
569-573.
Artículo
43 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A. (2001). Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Journal of Physiology,
534 (Pt 3),
721-732.
Carta
44 - Bottiglieri,C., Ferrara,L., Corona,M., Gurrola,G.B., Batista,C., Wanke,E., Possani,L.D. (2000). Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel.
FEBS Letters,
479 (3),
156-157 .
Artículo
45 - Torres-Larios,A., Gurrola,G.B., Zamudio,F.Z., Possani,L.D. (2000). Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
European Journal of Biochemistry,
267 (16),
5023-5031.
Artículo
46 - Calderon-Aranda,E.S., Selisko,B., York,E.J., Gurrola,G.B., Stewart,J.M., Possani,L.D. (1999). Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
European Journal of Biochemistry,
264 (3),
746-755.
Artículo
47 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E. (1999). A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom.
FASEB Journal,
13 (8),
953-962.
Artículo
48 - Gurrola,G.B., Arevalo,C., Sreekumar,R., Lokuta,A.J., Walker,J.W., Valdivia,H.H. (1999). Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor.
Journal of Biological Chemistry,
274 (12),
7879-7886.
*
Revisión
49 - Possani,L.D., Selisko,B., Gurrola,G.B. (1999). Structure and function of scorpion toxins affecting K+-channels.
Perspectives In Drug Discovery And Design,
16,
15-40.
Artículo
50 - Samso,M., Trujillo,R., Gurrola,G.B., Valdivia,H.H., Wagenknecht,T. (1999). Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor.
Journal of Cell Biology,
146 (2),
493-499.
*
Artículo
51 - Zhu,X., Gurrola,G., Jiang,M.T., Walker,J.W., Valdivia,H.H. (1999). Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors.
FEBS Letters,
450 (3),
221-226.
*
Artículo
52 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B. (1998). Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Artículo
Artículo
54 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D. (1997). Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.
FEBS Letters,
405 (3),
385-389.
Artículo
55 - Dehesa-Davila,M., Ramirez,A.N., Zamudio,F.Z., Gurrola-Briones,G., Lievano,A., Darszon,A., Possani,L.D. (1996). Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
113 (2),
331-339.
Artículo
56 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D. (1996). Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
57 - Nieto,A.R., Gurrola,G.B., Vaca,L., Possani,L.D. (1996). Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
913-922.
Artículo
58 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D. (1996). A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
59 - Dauplais,M., Gilquin,B., Possani,L.D., Gurrola-Briones,G., Roumestand,C., Menez,A. (1995). Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins.
Biochemistry,
34 (51),
16563-16573.
Artículo
60 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C. (1995). Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.
Biochemical and Biophysical Research Communications,
213 (3),
901-907.
Artículo
61 - Gurrola,G.B., Possani,L.D. (1995). Structural and functional features of noxiustoxin: a K+ channel blocker.
Biochemistry and Molecular Biology International,
37 (3),
527-535.
Artículo
62 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D. (1995). Monoclonal antibodies against noxiustoxin.
Hybridoma,
14 (3),
247-251.
Artículo
63 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D. (1994). The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Artículo
64 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D. (1994). Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemical Journal,
304 (Pt 1),
51-56.
Artículo
65 - Ramirez,A.N., Martin,B.M., Gurrola,G.B., Possani,L.D. (1994). Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Toxicon,
32 (4),
479-490.
Artículo
66 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L. (1993). Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker.
Journal of Membrane Biology,
134 (2),
123-129.
Artículo
67 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M. (1992). Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels.
Toxicon,
30 (11),
1343-1364.
Artículo
68 - Zamudio,F., Saavedra,R., Martin,B.M., Gurrola-Briones,G., Herion,P., Possani,L.D. (1992). Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann.
European Journal of Biochemistry,
204 (1),
281-292.
Artículo
69 - Gurrola,G.B., Molinar-Rode,R., Sitges,M., Bayon,A., Possani,L.D. (1989). Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion.
Journal of Neural Transmission,
77 (1),
11-20.
Artículo
70 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D. (1988). Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
785-794.
Artículo
71 - Ramirez,A.N., Gurrola,G.B., Martin,B.M., Possani,L.D. (1988). Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
773-783.
Artículo
72 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D. (1987). Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.
Circulation Research,
61 (4 Pt 2),
I6-I9.
Internacional
73 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R. (2011). Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas .
147-180,
Mexico.
Internacional
74 - Gurrola,G.B., Zhu,X., Valdivia,H (2005). Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function. Ryanodine receptors : structure, function and dysfunction in clinical disease.
Developments in Cardiovascular Medicine,
191-200,
254,
New York.
Memoria in extenso
75 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D. (1991). Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America.
7 p,
Caracas.
Memoria in extenso
76 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E. (1991). Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Nacional
77 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D. (1984). Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos.
35-50.
Preprint
78 - Sheard,T.M.D., Howlett,L., Kirton,H., Yang,Z., Gurrola,G., Steele,D., Jayasinghe,I., Valdivia,H.H., Colyer,J. (2020). Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes.
bioRxiv,
Preprint posted June 28.
79 - Gurrola Briones, Georgina (1994). Caracterizacion funcional estructural de la noxiustoxina.
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Possani, Lourival Domingos
80 - Gurrola Briones, Georgina (1986). Sintesis quimica de peptidos correspondientes a secuencias de aminoacidos de toxinas de alacran y sus propiedades.
Instituto de Biotecnologia,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Possani, Lourival Domingos
81 - Gurrola Briones, Georgina (1981). Busqueda e identificacion de anticuerpos contra antigenos del sistema hla .
FES Cuautitlan,
Quimico Farmaceutico Biologo,
UNAM.
*
Asesor: Teran Ortiz, Luis Angel
Artículo
82 - Haji-Ghassemi,O., Chen,Y.S., Woll,K., Gurrola,G.B., Valdivia,C.R., Cai,W., Li,S., Valdivia,H.H., Van Petegem,F.. Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation.
Science Advances,
9 (21),
eadf4936.
Artículo
83 - Naseem,M.U., Gurrola-Briones,G., Romero-Imbachi,M.R., Borrego,J., Carcamo-Noriega,E., Beltran-Vidal,J., Zamudio,F.Z., Shakeel,K., Possani,L.D., Panyi,G.. Characterization and Chemical Synthesis of Cm39 (à-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1.
Toxins (Basel),
15 (1),
41.
Artículo
84 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G.. sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochemical Pharmacology,
199,
115023.
Artículo
85 - Garcia-Guerrero,I.A., Carcamo-Noriega,E., Gomez-Lagunas,F., Gonzalez-Santillan,E., Zamudio,F.Z., Gurrola,G.B., Possani,L.D.. Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans.
Toxicon,
173,
27-38.
Preprint
86 - Sheard,T.M.D., Howlett,L., Kirton,H., Yang,Z., Gurrola,G., Steele,D., Jayasinghe,I., Valdivia,H.H., Colyer,J.. Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes.
bioRxiv,
Preprint posted June 28.
Artículo
87 - Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., Possani, L. D.. Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function.
Toxicon,
167,
184-191.
Artículo
89 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H.. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.
Journal of General Physiology,
147 (5),
375-394.
Revisión
90 - Ortiz,E., Gurrola,G.B., Schwartz,E.F., Possani,L.D.. Scorpion venom components as potential candidates for drug development.
Toxicon,
93,
125-135.
Artículo
91 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Powers,P.P., Willis,B.C., Moss,R.L., Jalife,J., Valdivia,H.H.. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.
Proceedings of the National Academy of Sciences of the United States of America,
112 (13),
E1669-E1677.
Revisión
92 - Zhao,Y.T., Valdivia,C.R., Gurrola,G.B., Hernandez,J.J., Valdivia,H.H.. Arrhythmogenic mechanisms in ryanodine receptor channelopathies.
Science China Life Sciences,
58 (1),
54-58.
Revisión
93 - Quintero-Hernandez,V., Jimenez-Vargas,J.M., Gurrola,G.B., Valdivia,H.H., Possani,L.D.. Scorpion venom components that affect ion-channels function.
Toxicon,
76,
328-342.
Artículo
94 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B.. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
95 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D.. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1830 (6),
3427-3436.
Artículo
96 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D.. Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry,
51 (19),
4049-4061.
Artículo
97 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D.. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
98 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G.. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells.
Molecular Pharmacology,
82 (3),
372-382.
Artículo
99 - Hernandez-Aponte,C.A., Silva-Sanchez,J., Quintero-Hernandez,V., Rodriguez-Romero,A., Balderas,C., Possani,L.D., Gurrola,G.B.. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.
Toxicon,
57 (1),
84-92.
Artículo; Actas Paper
100 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Quintero-Hernandez,V., Gurrola,G.B., Possani,L.D.. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.
Peptides,
32 (3),
560-567.
Internacional
101 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R.. Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas .
147-180,
Mexico.
Artículo
102 - Gurrola,G.B., Capes,E.M., Zamudio,F.Z., Possani,L.D., Valdivia,H.H.. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.
Pharmaceuticals.(Basel),
3 (4),
1093-1107.
Revisión
103 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D.. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells.
Toxicology Letters,
187 (1),
1-9.
Artículo
104 - Aparicio-Fabre,R., Guillen,G., Estrada,G., Olivares-Grajales,J., Gurrola,G., Sanchez,F.. Profilin tyrosine phosphorylation in poly-l-proline-binding regions inhibits binding to phosphoinositide 3-kinase in Phaseolus vulgaris.
Plant Journal,
47 (4),
491-500.
Artículo; Actas Paper
105 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E.. Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS.
Molecular Pharmacology,
69 (5),
1673-1683.
Artículo
106 - Schiavon,E., Sacco,T., Restano-Cassulini,R., Gurrola,G., Tempia,F., Possani,L.D., Wanke,E.. Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons.
Journal of Biological Chemistry,
281 (29),
20326-20337.
Artículo
107 - Coronas,F.I., Balderas,C., Lopez,L.P., Possani,L.D., Gurrola,G.B.. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus.
Journal of the Brazilian Chemical Society,
16 (3A),
404-411.
Internacional
108 - Gurrola,G.B., Zhu,X., Valdivia,H. Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function. Ryanodine receptors : structure, function and dysfunction in clinical disease.
Developments in Cardiovascular Medicine,
191-200,
254,
New York.
Artículo
109 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M.. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels.
Proteins,
56 (2),
367-375.
Artículo
110 - Rosales-Castillo,J.A., Acosta-Saavedra,L.C., Torres,R., Ochoa-Fierro,J., Borja-Aburto,V.H., Lopez-Carrillo,L., Garcia-Vargas,G.G., Gurrola,G.B., Cebrian,M.E., Calderon-Aranda,E.S.. Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study.
International Archives of Occupational and Environmental Health,
77 (6),
418-423.
Artículo
111 - Gazarian,T.G., Selisko,B., Gurrola,G.B., Possani,L.D., Gazarian,K.G.. Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2.
Combinatorial Chemistry & High Throughput Screening,
6 (2),
119-132.
Artículo
112 - Corona,M., Gurrola,G.B., Merino,E., Cassulini,R.R., Valdez-Cruz,N.A., Garcia,B, Ramirez-Dominguez,M.E., Coronas,F.I., Zamudio,F.Z., Wanke,E., Possani,L.D.. A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides.
FEBS Letters,
532 (1-2),
121-126.
Artículo
113 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E.. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Journal of Neuroscience,
22 (9),
3414-3425.
Artículo
114 - Pardo-Lopez,L., Garcia-Valdes,J., Gurrola,G.B., Robertson,G.A., Possani,L.D.. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Letters,
510 (1-2),
45-49.
Artículo
115 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G.. Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells.
European Biophysics Journal,
29 (8),
569-573.
Artículo
116 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A.. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Journal of Physiology,
534 (Pt 3),
721-732.
Carta
117 - Bottiglieri,C., Ferrara,L., Corona,M., Gurrola,G.B., Batista,C., Wanke,E., Possani,L.D.. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel.
FEBS Letters,
479 (3),
156-157 .
Artículo
118 - Torres-Larios,A., Gurrola,G.B., Zamudio,F.Z., Possani,L.D.. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
European Journal of Biochemistry,
267 (16),
5023-5031.
Artículo
119 - Calderon-Aranda,E.S., Selisko,B., York,E.J., Gurrola,G.B., Stewart,J.M., Possani,L.D.. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
European Journal of Biochemistry,
264 (3),
746-755.
Artículo
120 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E.. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom.
FASEB Journal,
13 (8),
953-962.
Artículo
121 - Gurrola,G.B., Arevalo,C., Sreekumar,R., Lokuta,A.J., Walker,J.W., Valdivia,H.H.. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor.
Journal of Biological Chemistry,
274 (12),
7879-7886.
*
Revisión
122 - Possani,L.D., Selisko,B., Gurrola,G.B.. Structure and function of scorpion toxins affecting K+-channels.
Perspectives In Drug Discovery And Design,
16,
15-40.
Artículo
123 - Samso,M., Trujillo,R., Gurrola,G.B., Valdivia,H.H., Wagenknecht,T.. Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor.
Journal of Cell Biology,
146 (2),
493-499.
*
Artículo
124 - Zhu,X., Gurrola,G., Jiang,M.T., Walker,J.W., Valdivia,H.H.. Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors.
FEBS Letters,
450 (3),
221-226.
*
Artículo
125 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B.. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Artículo
Artículo
127 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D.. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.
FEBS Letters,
405 (3),
385-389.
Artículo
128 - Dehesa-Davila,M., Ramirez,A.N., Zamudio,F.Z., Gurrola-Briones,G., Lievano,A., Darszon,A., Possani,L.D.. Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
113 (2),
331-339.
Artículo
129 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D.. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
130 - Nieto,A.R., Gurrola,G.B., Vaca,L., Possani,L.D.. Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
913-922.
Artículo
131 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D.. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
132 - Dauplais,M., Gilquin,B., Possani,L.D., Gurrola-Briones,G., Roumestand,C., Menez,A.. Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins.
Biochemistry,
34 (51),
16563-16573.
Artículo
133 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C.. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.
Biochemical and Biophysical Research Communications,
213 (3),
901-907.
Artículo
134 - Gurrola,G.B., Possani,L.D.. Structural and functional features of noxiustoxin: a K+ channel blocker.
Biochemistry and Molecular Biology International,
37 (3),
527-535.
Artículo
135 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D.. Monoclonal antibodies against noxiustoxin.
Hybridoma,
14 (3),
247-251.
Artículo
136 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D.. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Artículo
137 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D.. Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemical Journal,
304 (Pt 1),
51-56.
Artículo
138 - Ramirez,A.N., Martin,B.M., Gurrola,G.B., Possani,L.D.. Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Toxicon,
32 (4),
479-490.
139 - Gurrola Briones, Georgina. Caracterizacion funcional estructural de la noxiustoxina.
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Teran Ortiz, Luis Angel
Artículo
140 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L.. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker.
Journal of Membrane Biology,
134 (2),
123-129.
Artículo
141 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M.. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels.
Toxicon,
30 (11),
1343-1364.
Artículo
142 - Zamudio,F., Saavedra,R., Martin,B.M., Gurrola-Briones,G., Herion,P., Possani,L.D.. Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann.
European Journal of Biochemistry,
204 (1),
281-292.
Memoria in extenso
143 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D.. Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America.
7 p,
Caracas.
Memoria in extenso
144 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E.. Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Artículo
145 - Gurrola,G.B., Molinar-Rode,R., Sitges,M., Bayon,A., Possani,L.D.. Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion.
Journal of Neural Transmission,
77 (1),
11-20.
Artículo
146 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D.. Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
785-794.
Artículo
147 - Ramirez,A.N., Gurrola,G.B., Martin,B.M., Possani,L.D.. Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
773-783.
Artículo
148 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D.. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.
Circulation Research,
61 (4 Pt 2),
I6-I9.
149 - Gurrola Briones, Georgina. Sintesis quimica de peptidos correspondientes a secuencias de aminoacidos de toxinas de alacran y sus propiedades.
Instituto de Biotecnologia,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Teran Ortiz, Luis Angel
Nacional
150 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D.. Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos.
35-50.
151 - Gurrola Briones, Georgina. Busqueda e identificacion de anticuerpos contra antigenos del sistema hla .
FES Cuautitlan,
Quimico Farmaceutico Biologo,
UNAM.
*
Asesor: Teran Ortiz, Luis Angel