Dr. Daniel Genaro Segura Gonzalez
Investigador
Ingeniería y Tecnología de las Fermentaciones y del Cultivo Celular
Número de registros: 6
- Vencidos
- Estudio de la degradación (movilización) del polímero polihidroxibutirato en azotobacter vinelandii y su regulación genética, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2016 - 2021
- Establecimiento de condiciones de cultivo en bio-reactores de cepas de azotobacter vinelandii modificadas genéticamente para la producción de plásticos biodegradables, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2015 - 2018
- Producción de polihidroxialcanoatos de composición controlada para la generación de plásticos biodegradables con propiedades diversas, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2012 - 2014
- Estudio de los factores que determinan la composición monomérica de los poliésteres biodegradables producidos por una cepa recombinante de azotobacter vinelandii, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2011 - 2014
- Estudio del control del metabolismo de poliésteres polihidroxialcanoatos, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2009 - 2011
- Biología molecular de la síntesis del poliéster natural polihidroxibutirato en azotobacter vinelandii, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1998 - 1999
Nivel C del PRIDE
Nivel II del SNI
Nivel II del SNI
Doctorado, en Biotecnología, IBt-UNAM (1998)
Maestría, en Biotecnología, Instituto de Investigaciones Biomedicas-UNAM (1993)
Licenciatura, Biología, Fac. de Ciencias-UNAM (1987)
-
Doctorado
-
M.C. Claudia Velazquez Sanchez
Caracterización del gen Hexr1 como posible regulador de la via Enter-Doudoroff y su papel en la síntesis de alginato en Azotobacter vinelandii
-
Maestría
-
Estudio del papel de las proteínas Avin34710 y Avin34720 en el metabolismo de polihidroxibutirato (PHB) en la bacteria Azotobacter vinelandii.
-
Licenciatura
-
Estancia Temporal
1 - Ruiz Escobedo, Jessica (2020). Estudio del papel de las proteinas Avin34710 y Avin34720 en el metabolismo de polihidroxibutirato (PHB) en la bacteria Azotobacter vinelandii.
Instituto de Biotecnologia,
Maestría en Ciencias Bioquímicas,
UNAM.
Asesor: Segura Gonzalez, Daniel Genaro
2 - Barrientos Millan, Thalia (2020). Estudio del papel de los reguladores PhbF y Avin_33510 en la expresion de las depolimerasas de PHB en Azotobacter vinelandii.
Instituto de Biotecnologia,
Maestría en Ciencias Bioquímicas,
UNAM.
Asesor: Segura Gonzalez, Daniel Genaro
3 - Morales Flores, Gabriela (2019). Biosintesis de polihidroxialcanoatos de longitud de cadena media en Azotobacter vinelandii OP a partir de acidos grasos o sacarosa para la obtencion de bioplasticos.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Segura Gonzalez, Daniel Genaro
4 - Romero Ramirez, Yanet (2013). Regulación de la expresión de los genes de biosíntesis de alquilresorcinoles por los sistemas gac, rsm, el factor sigma rpos y el regulador transcripcional arpr en azotobacter vinelandii .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Segura Gonzalez, Daniel
5 - Alva Silva, Andrea (2013). Modificaciones en la cadena respiratoria de Azotobacter Vinelandii para la produccion del Bioplastico Poli-Beta-Hidroxibutirato.
Facultad de Ciencias,
Licenciatura en Biologia,
UNAM.
Asesor: Segura Gonzalez, Daniel Genaro
6 - Yanajara Parra, Deborah (2012). Estudio de la degradación intracelular del polihidroxibutirato (PHB) en Azotobacter Vinelandii .
Instituto de Biotecnologia,
Maestría en Ciencias Bioquímicas,
UNAM.
Asesor: Segura Gonzalez, Daniel
7 - Romero Ramirez, Yanet (2008). Regulacion de la expresion genetica de arsA en Azotobacter Vinelandii .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Segura Gonzalez, Daniel Genaro
Total de publicaciones: 56
- Tipo
- Fecha
Artículo
8 - Gomez-Hernandez,E., Salgado-Lugo,H., Segura,D., Garcia,A., Diaz-Barrera,A., Pena,C. (2021). Production of Poly-3-Hydroxybutyrate (P3HB) with Ultra-High Molecular Weight (UHMW) by Mutant Strains of Azotobacter vinelandii Under Microaerophilic Conditions.
Applied Biochemistry and Biotechnology,
193 (1),
79-95.
Artículo
9 - Torres-Pedraza,A.J., Salgado-Lugo,H., Segura,D., Diaz-Barrera,A., Pena,C. (2021). Composition control of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymerization by oxygen transfer rate (OTR) in Azotobacter vinelandii OPNA.
Journal of Chemical Technology and Biotechnology,
96 (10),
2782-2791.
Artículo
10 - Velazquez-Sanchez,C., Vences-Guzman,M.A., Moreno,S., Tinoco-Valencia,R., Espin,G., Guzman,J., Sahonero-Canavesi,D.X., Sohlenkamp,C., Segura,D. (2021). PsrA positively regulates the unsaturated fatty acid synthesis operon fabAB in Azotobacter vinelandii.
Microbiological Research,
249,
126775.
Artículo
11 - Serrano-Angel,L., Segura-Gonzalez,D., Toribio-Jimenez,J., Rodriguez-Barrera,M.A., Otuno-Pineda,C., Romero-Ramirez,Y (2020). Carbon storage regulator A (csrA) gene regulates motility and growth of bacillus licheniformis in the presence of hydrocarbons.
Microbiology and Biotechnology Letters,
48 (2),
185-192.
Revisión
12 - Velazquez-Sanchez,C., Espin,G., Pena,C., Segura,D. (2020). The Modification of Regulatory Circuits Involved in the Control of Polyhydroxyalkanoates Metabolism to Improve Their Production.
Frontiers in Bioengineering and Biotechnology,
8,
386.
Artículo
13 - Salcedo-Vite,K., Sigala,J.C., Segura,D., Gosset,G., Martinez,A. (2019). Acinetobacter baylyi ADP1 growth performance and lipid accumulation on different carbon sources.
Applied Microbiology and Biotechnology,
103 (15),
6217-6229.
Artículo
14 - Adaya, L., Millan, M., Pena, C., Jendrossek, D., Espin, G., Tinoco-Valencia, R., Guzman, J., Pfeiffer, D., Segura, D. (2018). Inactivation of an intracellular poly-3-hydroxybutyrate depolymerase of Azotobacter vinelandii allows to obtain a polymer of uniform high molecular mass.
Applied Microbiology and Biotechnology,
102 (6),
2693-2707.
Artículo
15 - Castillo, T., Lopez, I., Flores, C., Segura, D., Garcia, A., Galindo, E., Pena, C. (2018). Oxygen uptake rate in alginate producer (algU+) and non-producer (algU-) strains of Azotobacter vinelandii under nitrogen-fixation conditions.
Journal of Applied Microbiology,
125 (1),
181-189.
Artículo
16 - Chowdhury-Paul, S., Pando-Robles, V., Jimenez-Jacinto, V., Segura, D., Espin, G., Nunez, C. (2018). Proteomic analysis revealed proteins induced upon Azotobacter vinelandii encystment.
Journal of Proteomics,
181,
47-59.
Artículo
17 - Garcia, A., Ferrer, P., Albiol, J., Castillo, T., Segura, D., Pena, C. (2018). Metabolic flux analysis and the NAD(P)H/NAD(P)(+) ratios in chemostat cultures of Azotobacter vinelandii.
Microbial Cell Factories,
17,
10.
Artículo
18 - Castillo, T., Flores,C., Segura, D., Espin, G., Sanguino, J., Cabrera, E., Barreto, J., Diaz-Barrera, A., Pena, C. (2017). Production of polyhydroxybutyrate (PHB) of high and ultra-high molecular weight by Azotobacter vinelandii in batch and fed-batch cultures.
Journal of Chemical Technology and Biotechnology,
92 (7),
1809-1816.
Artículo
19 - Millan, M., Salazar, M., Segura, D., Castillo, T., Diaz-Barrera, A., Pena, C. (2017). Molecular mass of Poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is influenced by the polymer content in the inoculum.
Journal of Biotechnology,
259,
50-55.
Artículo
20 - Romero-Ramirez, Y., Hernandez-Flores, G., Rodriguez-Barrera, M.A., Segura-Gonzalez, D., Martinez-Galero, N.X., Toribio-Jimenez, J., Castellanos Escamilla, M., Hernandez-Eligio, J.A. (2017). Evaluation of polyhydroxyalkanoates producing bacteria isolated from soils with wastes of Cocos nucifera.
Revista Internacional de Contaminacion Ambiental,
33,
115-123.
Artículo
21 - Jimenez,L., Castillo,T., Flores,C., Segura,D., Galindo,E., Pena,C. (2016). Analysis of respiratory activity and carbon usage of a mutant of Azotobacter vinelandii impaired in poly-beta-hydroxybutyrate synthesis.
Journal of Industrial Microbiology & Biotechnology,
43 (8),
1167-1174.
Artículo
22 - Millan,M., Segura,D., Galindo,E., Pena,C. (2016). Molecular mass of poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is determined by the ratio of synthesis and degradation under fixed dissolved oxygen tension.
Process Biochemistry,
51 (8),
950-958.
Artículo
23 - Romero,Y., Guzman,J., Moreno,S., Cocotl-Yanez,M., Vences-Guzman,M.A., Castaneda,M., Espin,G., Segura,D. (2016). The GacS/A-RsmA Signal Transduction Pathway Controls the Synthesis of Alkylresorcinol Lipids that Replace Membrane Phospholipids during Encystment of Azotobacter vinelandii SW136.
PLoS ONE,
11 (4),
e0153266.
Artículo
24 - Romero-Rodriguez,A., Rocha,D., Ruiz-Villafan,B., Tierrafria,V., Rodriguez-Sanoja,R., Segura-Gonzalez,D., Sanchez,S. (2016). Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor.
BMC Microbiology,
16 (1),
77.
Artículo
25 - Dominguez-Diaz,M., Meneses-Acosta,A., Romo-Uribe,A., Pena,C., Segura,D., Espin,G. (2015). Thermo-mechanical properties, microstructure and biocompatibility in poly-beta-hydroxybutyrates (PHB) produced by OP and OPN strains of Azotobacter vinelandii.
European Polymer Journal,
63,
101-112.
Artículo
26 - Muriel-Millan,L.F., Moreno,S., Romero,Y., Bedoya-Perez,L.P., Castaneda,M., Segura,D., Espin,G. (2015). The Unphosphorylated EIIANtr Protein Represses the Synthesis of Alkylresorcinols in Azotobacter vinelandii.
PLoS ONE,
10 (2),
e0117184.
Artículo
27 - Catone,M.V., Ruiz,J.A., Castellanos,M., Segura,D., Espin,G., Lopez,N.I. (2014). High Polyhydroxybutyrate Production in Pseudomonas extremaustralis Is Associated with Differential Expression of Horizontally Acquired and Core Genome Polyhydroxyalkanoate Synthase Genes.
PLoS ONE,
9 (6),
e98873.
Artículo
28 - Garcia,A., Segura,D., Espin,G., Galindo,E., Castillo,T., Pena,C. (2014). High production of poly-beta-hydroxybutyrate (PHB) by an Azotobacter vinelandii mutant altered in PHB regulation using a fed-batch fermentation process.
Biochemical Engineering Journal,
82,
117-123.
Revisión
29 - Pena,C., Castillo,T., Garcia,A., Millan,M., Segura,D. (2014). Biotechnological strategies to improve production of microbial poly-(3-hydroxybutyrate): a review of recent research work.
Microbial Biotechnology,
7 (4),
278-293.
Artículo
30 - Pena,C., Lopez,S., Garcia,A., Espin,G., Romo-Uribe,A., Segura,D. (2014). Biosynthesis of poly-á-hydroxybutyrate (PHB) with a high molecular mass by a mutant strain of Azotobacter vinelandii (OPN).
Annals of Microbiology,
64 (1),
39-47.
Artículo
31 - Toribio-Jimenez,J., Rodriguez-Barrera,M.A., Vladez-Lucena,M., Barrera-Flores,A., Segura,D., Wilson-Corral,V., Flores-Alfaro,E., Romero,Y. (2014). Production of biosurfactants by bacteria isolated from a mine tailing zone in Southern Mexico and their resistance to heavy metals.
Journal of Bacteriology Research,
6 (4),
23-31.
Artículo
32 - Romero,Y., Moreno,S., Guzman,J., Espin,G., Segura,D. (2013). The Sigma Factor RpoS Controls Alkylresorcinol Synthesis Through ArpR, a LysR-Type Regulatory Protein During Encystment of Azotobacter vinelandii.
Journal of Bacteriology,
195 (8),
1834-1844.
Artículo
33 - Cocotl-Yanez,M., Sampieri,A., Moreno,S., Nunez,C., Castaneda,M., Segura,D., Espin,G. (2011). Roles of RpoS and PsrA in cyst formation and alkylresorcinol synthesis in Azotobacter vinelandii.
Microbiology,
157 (6),
1685-1693.
Artículo
34 - Manzo,J., Cocotl-Yanez,M., Tzontecomani,T., Martinez,V.M., Bustillos,R., Velasquez,C., Goiz,Y., Solis,Y., Lopez,L., Fuentes,L.E., Nunez,C., Segura,D., Espin,G., Castaneda,M. (2011). Post-Transcriptional Regulation of the Alginate Biosynthetic Gene algD by the Gac/Rsm System in Azotobacter vinelandii.
Journal of Molecular Microbiology and Biotechnology,
21 (3-4),
147-159.
Artículo
35 - Mejia,M.A., Segura,D., Espin,G., Galindo,E., Pena,C. (2010). Two-stage fermentation process for alginate production by Azotobacter vinelandii mutant altered in poly-beta-hydroxybutyrate (PHB) synthesis.
Journal of Applied Microbiology,
108 (1),
55-61.
Artículo
36 - Segura,D., Vite,O., Romero,Y., Moreno,S., Castaneda,M., Espin,G. (2009). Isolation and Characterization of Azotobacter vinelandii Mutants Impaired in Alkylresorcinol Synthesis: Alkylresorcinols are not Essential for Cysts Desiccation Resistance.
Journal of Bacteriology,
191 (9),
3142-3148.
Artículo
37 - Setubal,J.C., Dos Santos P., Goldman,B.S., Ertesvag,H., Espin,G., Rubio,L.M., Valla,S., Almeida,N.F., Balasubramanian,D., Cromes,L., Curatti,L., Du,Z., Godsy,E., Goodner,B., Hellner-Burris,K., Hernandez,J.A., Houmiel,K., Imperial,J., Kennedy,C., Larson,T.J., Latreille,P., Ligon,L.S., Lu,J., Maerk,M., Miller,N.M., Norton,S., O'Carroll,I.P., Paulsen,I., Raulfs,E.C., Roemer,R., Rosser,J., Segura,D., Slater,S., Stricklin,S.L., Studholme,D.J., Sun,J., Viana,C.J., Wallin,E., Wang,B., Wheeler,C., Zhu,H., Dean,D.R., Dixon,R., Wood,D. (2009). The genome sequence of Azotobacter vinelandii, an obligate aerobe specialized to support diverse anaerobic metabolic processes.
Journal of Bacteriology,
191 (14),
4534-4545.
Artículo
38 - Noguez,R., Segura,D., Moreno,S., Hernandez,A., Juarez,K., Espin,G. (2008). Enzyme I, NPr and IIA(Ntr) Are Involved in Regulation of the Poly-beta-Hydroxybutyrate Biosynthetic Genes in Azotobacter vinelandii.
Journal of Molecular Microbiology and Biotechnology,
15 (4),
244-254.
Artículo
39 - Segura,D., Mahadevan,R., Juarez,K., Lovley,D.R. (2008). Computational and experimental analysis of redundancy in the central metabolism of Geobacter sulfurreducens.
PLoS Computational Biology,
4 (2),
e36 (erratum en 4(3). doi: 10.1371/annotation/67743d4d-2993-4d0c-951b-3f11ce65a8b4.).
Revisión
40 - Galindo,E., Pena,C., Nunez,C., Segura,D., Espin,G. (2007). Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii.
Microbial Cell Factories,
6 (1),
7.
Artículo
41 - Segura,D., Espin,G. (2004). Inactivation of pycA, encoding pyruvate carboxylase activity, increases poly-beta-hydroxybutyrate accumulation in Azotobacter vinelandii on solid medium.
Applied Microbiology and Biotechnology,
65 (4),
414-418.
Artículo
42 - Segura,D., Guzman,J., Espin,G. (2003). Azotobacter vinelandii mutants that overproduce poly-beta-hydroxybutyrate or alginate.
Applied Microbiology and Biotechnology,
63 (2),
159-163.
Artículo
43 - Segura,D., Cruz,T., Espin,G. (2003). Encystment and alkylresorcinol production by Azotobacter vinelandii strains impaired in poly-beta-hydroxybutyrate synthesis.
Archives of Microbiology,
179 (6),
437-443.
Artículo
44 - Trujillo-Roldan,M.A., Moreno,S., Segura,D., Galindo,E., Espin,G. (2003). Alginate production by an Azotobacter vinelandii mutant unable to produce alginate lyase.
Applied Microbiology and Biotechnology,
60 (6),
733-737.
Artículo
45 - Pena,C., Miranda,L., Segura,D., Nunez,C., Espin,G., Galindo,E. (2002). Alginate production by Azotobacter vinelandii mutants altered in poly-beta-hydroxybutyrate and alginate biosynthesis.
Journal of Industrial Microbiology & Biotechnology,
29 (5),
209-213.
Artículo
46 - Peralta-Gil,M., Segura,D., Guzman,J., Servin-Gonzalez,L., Espin,G. (2002). Expression of the Azotobacter vinelandii Poly-beta-Hydroxybutyrate Biosynthetic phbBAC Operon Is Driven by Two Overlapping Promoters and Is Dependent on the Transcriptional Activator PhbR.
Journal of Bacteriology,
184 (20),
5672-5677.
Artículo
47 - Gama-Castro,S., Nunez,C., Segura,D., Moreno,S., Guzman,J., Espin,G. (2001). Azotobacter vinelandii Aldehyde Dehydrogenase Regulated by sigma(54): Role in Alcohol Catabolism and Encystment.
Journal of Bacteriology,
183 (21),
6169-6174.
Artículo
48 - Segura,D., Vargas,E., Espin,G. (2000). Beta-ketothiolase genes in Azotobacter vinelandii.
Gene,
260 (1-2),
113-120.
Artículo
49 - Segura,D., Espin,G. (1998). Mutational inactivation of a gene homologous to Escherichia coli ptsP affects poly-beta-hydroxybutyrate accumulation and nitrogen fixation in Azotobacter vinelandii.
Journal of Bacteriology,
180 (18),
4790-4798.
Artículo
50 - Segura,D., Santana,C., Gosh,R., Escalante,L., Sanchez,S. (1997). Anthracyclines: isolation of overproducing strains by the selection and genetic recombination of putative regulatory mutants of Streptomyces peucetius var. caesius.
Applied Microbiology and Biotechnology,
48 (5),
615-620.
*
Internacional
51 - Segura,D., Nunez,C., Espin,G. (2020). Azotobacter Cysts. eLS .
Chichester, West Sussex: Editorial John Wiley & Sons.
Divulgación
52 - Nuñez-Lopez,C.E., Segura-Gonzalez,D.G. (2014). La contaminación por plásticos: bacterias al rescate. Un Mundo de Bacterias .
105-108.
Internacional
53 - Romero,Y., Pena,C., Rojas,A., Tortajada,M., Espin,G., Segura,D. (2014). Una mutante de Azotobacter vinelandii productora de PHB que carece de los reguladores RsmA y la Enzima IIANtr utiliza la fuente de carbono mas eficientemente. Bioplasticos .
23-31,
Lisboa, Portugal.
Internacional
54 - Segura,D., Nunez,C., Espin,G. (2014). Azotobacter Cysts. Encyclopedia of Life Sciences.
Chichester, West Sussex: Wiley.
Internacional
55 - Pena,C., Castillo,T., Segura,D., Nunez,C. (2011). Bioprocess design: fermentation strategies for improving the production of alginate and poly-beta-hydroxybutyrate (PHB) by Azotobacter vinelandii. Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications.
217-242.
Nacional
56 - Segura,D., Noguez,R., Espin,G. (2008). Contaminación ambiental y bacterias productoras de plásticos biodegradables. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 31.
361-372,
Mexico, D.F..
Preprint
57 - Torres-Pedraza,A.J., Salgado-Lugo,H., Segura,D., Pena,C. (2021). Copolymerization of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Azotobacter vinelandii OPNA is determined by the oxygen transfer rate of the culture.
Research Square,
Preprint posted 15 Feb.
*
Divulgación
58 - Pena-Malacara,C., Segura-Gonzalez,D. (2011). Geles y plásticos hechos bajo diseño por fermentación bacteriana.
Hypatia,
35,
4-5.
Nacional
59 - Espin,G., Moreno,S., Segura,D., Moreno,Y. (2006). Alkylresorcinols synthesis and its role in the production of cysts in Azotobacter.
Revista Latinoamericana de Microbiologia,
48 (2),
129-130.
Nacional
60 - Santana,C., Segura,D., Sanchez,S. (1994). [Synthesis, function, and evolutionary origin of secondary metabolites produced by micro-organisms].
Revista Latinoamericana de Microbiologia,
36 (2),
139-158.
61 - Segura Gonzalez, Daniel Genaro (1998). Identificacion de genes de Azotobacter vinelandii involucrados en la sintesis de polihidroxibutirato o en su regulacion : analisis de una mutante en el gen ptsP .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
Asesor: Espin Ocampo, Elda Guadalupe
62 - Segura Gonzalez, Daniel Genaro (1995). Estudios sobre la produccion de doxorrubicina en mutantes de Streptomyce peucetius var. caesius.
Instituto de Investigaciones Biomedicas,
Maestria en Biotecnologia,
UNAM.
63 - Segura Gonzalez, Daniel Genaro (1990). Mejoramiento genetico de una cepa de streptomyces griseus productora de estreptomicina.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Artículo
64 - Gomez-Hernandez,E., Salgado-Lugo,H., Segura,D., Garcia,A., Diaz-Barrera,A., Pena,C.. Production of Poly-3-Hydroxybutyrate (P3HB) with Ultra-High Molecular Weight (UHMW) by Mutant Strains of Azotobacter vinelandii Under Microaerophilic Conditions.
Applied Biochemistry and Biotechnology,
193 (1),
79-95.
Artículo
65 - Torres-Pedraza,A.J., Salgado-Lugo,H., Segura,D., Diaz-Barrera,A., Pena,C.. Composition control of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymerization by oxygen transfer rate (OTR) in Azotobacter vinelandii OPNA.
Journal of Chemical Technology and Biotechnology,
96 (10),
2782-2791.
Artículo
66 - Velazquez-Sanchez,C., Vences-Guzman,M.A., Moreno,S., Tinoco-Valencia,R., Espin,G., Guzman,J., Sahonero-Canavesi,D.X., Sohlenkamp,C., Segura,D.. PsrA positively regulates the unsaturated fatty acid synthesis operon fabAB in Azotobacter vinelandii.
Microbiological Research,
249,
126775.
Preprint
67 - Torres-Pedraza,A.J., Salgado-Lugo,H., Segura,D., Pena,C.. Copolymerization of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Azotobacter vinelandii OPNA is determined by the oxygen transfer rate of the culture.
Research Square,
Preprint posted 15 Feb.
*
Artículo
68 - Serrano-Angel,L., Segura-Gonzalez,D., Toribio-Jimenez,J., Rodriguez-Barrera,M.A., Otuno-Pineda,C., Romero-Ramirez,Y. Carbon storage regulator A (csrA) gene regulates motility and growth of bacillus licheniformis in the presence of hydrocarbons.
Microbiology and Biotechnology Letters,
48 (2),
185-192.
Revisión
69 - Velazquez-Sanchez,C., Espin,G., Pena,C., Segura,D.. The Modification of Regulatory Circuits Involved in the Control of Polyhydroxyalkanoates Metabolism to Improve Their Production.
Frontiers in Bioengineering and Biotechnology,
8,
386.
Internacional
70 - Segura,D., Nunez,C., Espin,G.. Azotobacter Cysts. eLS .
Chichester, West Sussex: Editorial John Wiley & Sons.
Artículo
71 - Salcedo-Vite,K., Sigala,J.C., Segura,D., Gosset,G., Martinez,A.. Acinetobacter baylyi ADP1 growth performance and lipid accumulation on different carbon sources.
Applied Microbiology and Biotechnology,
103 (15),
6217-6229.
Artículo
72 - Adaya, L., Millan, M., Pena, C., Jendrossek, D., Espin, G., Tinoco-Valencia, R., Guzman, J., Pfeiffer, D., Segura, D.. Inactivation of an intracellular poly-3-hydroxybutyrate depolymerase of Azotobacter vinelandii allows to obtain a polymer of uniform high molecular mass.
Applied Microbiology and Biotechnology,
102 (6),
2693-2707.
Artículo
73 - Castillo, T., Lopez, I., Flores, C., Segura, D., Garcia, A., Galindo, E., Pena, C.. Oxygen uptake rate in alginate producer (algU+) and non-producer (algU-) strains of Azotobacter vinelandii under nitrogen-fixation conditions.
Journal of Applied Microbiology,
125 (1),
181-189.
Artículo
74 - Chowdhury-Paul, S., Pando-Robles, V., Jimenez-Jacinto, V., Segura, D., Espin, G., Nunez, C.. Proteomic analysis revealed proteins induced upon Azotobacter vinelandii encystment.
Journal of Proteomics,
181,
47-59.
Artículo
75 - Garcia, A., Ferrer, P., Albiol, J., Castillo, T., Segura, D., Pena, C.. Metabolic flux analysis and the NAD(P)H/NAD(P)(+) ratios in chemostat cultures of Azotobacter vinelandii.
Microbial Cell Factories,
17,
10.
Artículo
76 - Castillo, T., Flores,C., Segura, D., Espin, G., Sanguino, J., Cabrera, E., Barreto, J., Diaz-Barrera, A., Pena, C.. Production of polyhydroxybutyrate (PHB) of high and ultra-high molecular weight by Azotobacter vinelandii in batch and fed-batch cultures.
Journal of Chemical Technology and Biotechnology,
92 (7),
1809-1816.
Artículo
77 - Millan, M., Salazar, M., Segura, D., Castillo, T., Diaz-Barrera, A., Pena, C.. Molecular mass of Poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is influenced by the polymer content in the inoculum.
Journal of Biotechnology,
259,
50-55.
Artículo
78 - Romero-Ramirez, Y., Hernandez-Flores, G., Rodriguez-Barrera, M.A., Segura-Gonzalez, D., Martinez-Galero, N.X., Toribio-Jimenez, J., Castellanos Escamilla, M., Hernandez-Eligio, J.A.. Evaluation of polyhydroxyalkanoates producing bacteria isolated from soils with wastes of Cocos nucifera.
Revista Internacional de Contaminacion Ambiental,
33,
115-123.
Artículo
79 - Jimenez,L., Castillo,T., Flores,C., Segura,D., Galindo,E., Pena,C.. Analysis of respiratory activity and carbon usage of a mutant of Azotobacter vinelandii impaired in poly-beta-hydroxybutyrate synthesis.
Journal of Industrial Microbiology & Biotechnology,
43 (8),
1167-1174.
Artículo
80 - Millan,M., Segura,D., Galindo,E., Pena,C.. Molecular mass of poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is determined by the ratio of synthesis and degradation under fixed dissolved oxygen tension.
Process Biochemistry,
51 (8),
950-958.
Artículo
81 - Romero,Y., Guzman,J., Moreno,S., Cocotl-Yanez,M., Vences-Guzman,M.A., Castaneda,M., Espin,G., Segura,D.. The GacS/A-RsmA Signal Transduction Pathway Controls the Synthesis of Alkylresorcinol Lipids that Replace Membrane Phospholipids during Encystment of Azotobacter vinelandii SW136.
PLoS ONE,
11 (4),
e0153266.
Artículo
82 - Romero-Rodriguez,A., Rocha,D., Ruiz-Villafan,B., Tierrafria,V., Rodriguez-Sanoja,R., Segura-Gonzalez,D., Sanchez,S.. Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor.
BMC Microbiology,
16 (1),
77.
Artículo
83 - Dominguez-Diaz,M., Meneses-Acosta,A., Romo-Uribe,A., Pena,C., Segura,D., Espin,G.. Thermo-mechanical properties, microstructure and biocompatibility in poly-beta-hydroxybutyrates (PHB) produced by OP and OPN strains of Azotobacter vinelandii.
European Polymer Journal,
63,
101-112.
Artículo
84 - Muriel-Millan,L.F., Moreno,S., Romero,Y., Bedoya-Perez,L.P., Castaneda,M., Segura,D., Espin,G.. The Unphosphorylated EIIANtr Protein Represses the Synthesis of Alkylresorcinols in Azotobacter vinelandii.
PLoS ONE,
10 (2),
e0117184.
Artículo
85 - Catone,M.V., Ruiz,J.A., Castellanos,M., Segura,D., Espin,G., Lopez,N.I.. High Polyhydroxybutyrate Production in Pseudomonas extremaustralis Is Associated with Differential Expression of Horizontally Acquired and Core Genome Polyhydroxyalkanoate Synthase Genes.
PLoS ONE,
9 (6),
e98873.
Artículo
86 - Garcia,A., Segura,D., Espin,G., Galindo,E., Castillo,T., Pena,C.. High production of poly-beta-hydroxybutyrate (PHB) by an Azotobacter vinelandii mutant altered in PHB regulation using a fed-batch fermentation process.
Biochemical Engineering Journal,
82,
117-123.
Revisión
87 - Pena,C., Castillo,T., Garcia,A., Millan,M., Segura,D.. Biotechnological strategies to improve production of microbial poly-(3-hydroxybutyrate): a review of recent research work.
Microbial Biotechnology,
7 (4),
278-293.
Artículo
88 - Pena,C., Lopez,S., Garcia,A., Espin,G., Romo-Uribe,A., Segura,D.. Biosynthesis of poly-á-hydroxybutyrate (PHB) with a high molecular mass by a mutant strain of Azotobacter vinelandii (OPN).
Annals of Microbiology,
64 (1),
39-47.
Artículo
89 - Toribio-Jimenez,J., Rodriguez-Barrera,M.A., Vladez-Lucena,M., Barrera-Flores,A., Segura,D., Wilson-Corral,V., Flores-Alfaro,E., Romero,Y.. Production of biosurfactants by bacteria isolated from a mine tailing zone in Southern Mexico and their resistance to heavy metals.
Journal of Bacteriology Research,
6 (4),
23-31.
Divulgación
90 - Nuñez-Lopez,C.E., Segura-Gonzalez,D.G.. La contaminación por plásticos: bacterias al rescate. Un Mundo de Bacterias .
105-108.
Internacional
91 - Romero,Y., Pena,C., Rojas,A., Tortajada,M., Espin,G., Segura,D.. Una mutante de Azotobacter vinelandii productora de PHB que carece de los reguladores RsmA y la Enzima IIANtr utiliza la fuente de carbono mas eficientemente. Bioplasticos .
23-31,
Lisboa, Portugal.
Internacional
92 - Segura,D., Nunez,C., Espin,G.. Azotobacter Cysts. Encyclopedia of Life Sciences.
Chichester, West Sussex: Wiley.
Artículo
94 - Cocotl-Yanez,M., Sampieri,A., Moreno,S., Nunez,C., Castaneda,M., Segura,D., Espin,G.. Roles of RpoS and PsrA in cyst formation and alkylresorcinol synthesis in Azotobacter vinelandii.
Microbiology,
157 (6),
1685-1693.
Artículo
95 - Manzo,J., Cocotl-Yanez,M., Tzontecomani,T., Martinez,V.M., Bustillos,R., Velasquez,C., Goiz,Y., Solis,Y., Lopez,L., Fuentes,L.E., Nunez,C., Segura,D., Espin,G., Castaneda,M.. Post-Transcriptional Regulation of the Alginate Biosynthetic Gene algD by the Gac/Rsm System in Azotobacter vinelandii.
Journal of Molecular Microbiology and Biotechnology,
21 (3-4),
147-159.
Internacional
96 - Pena,C., Castillo,T., Segura,D., Nunez,C.. Bioprocess design: fermentation strategies for improving the production of alginate and poly-beta-hydroxybutyrate (PHB) by Azotobacter vinelandii. Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications.
217-242.
Divulgación
97 - Pena-Malacara,C., Segura-Gonzalez,D.. Geles y plásticos hechos bajo diseño por fermentación bacteriana.
Hypatia,
35,
4-5.
Artículo
98 - Mejia,M.A., Segura,D., Espin,G., Galindo,E., Pena,C.. Two-stage fermentation process for alginate production by Azotobacter vinelandii mutant altered in poly-beta-hydroxybutyrate (PHB) synthesis.
Journal of Applied Microbiology,
108 (1),
55-61.
Artículo
99 - Segura,D., Vite,O., Romero,Y., Moreno,S., Castaneda,M., Espin,G.. Isolation and Characterization of Azotobacter vinelandii Mutants Impaired in Alkylresorcinol Synthesis: Alkylresorcinols are not Essential for Cysts Desiccation Resistance.
Journal of Bacteriology,
191 (9),
3142-3148.
Artículo
100 - Setubal,J.C., Dos Santos P., Goldman,B.S., Ertesvag,H., Espin,G., Rubio,L.M., Valla,S., Almeida,N.F., Balasubramanian,D., Cromes,L., Curatti,L., Du,Z., Godsy,E., Goodner,B., Hellner-Burris,K., Hernandez,J.A., Houmiel,K., Imperial,J., Kennedy,C., Larson,T.J., Latreille,P., Ligon,L.S., Lu,J., Maerk,M., Miller,N.M., Norton,S., O'Carroll,I.P., Paulsen,I., Raulfs,E.C., Roemer,R., Rosser,J., Segura,D., Slater,S., Stricklin,S.L., Studholme,D.J., Sun,J., Viana,C.J., Wallin,E., Wang,B., Wheeler,C., Zhu,H., Dean,D.R., Dixon,R., Wood,D.. The genome sequence of Azotobacter vinelandii, an obligate aerobe specialized to support diverse anaerobic metabolic processes.
Journal of Bacteriology,
191 (14),
4534-4545.
Artículo
101 - Noguez,R., Segura,D., Moreno,S., Hernandez,A., Juarez,K., Espin,G.. Enzyme I, NPr and IIA(Ntr) Are Involved in Regulation of the Poly-beta-Hydroxybutyrate Biosynthetic Genes in Azotobacter vinelandii.
Journal of Molecular Microbiology and Biotechnology,
15 (4),
244-254.
Artículo
102 - Segura,D., Mahadevan,R., Juarez,K., Lovley,D.R.. Computational and experimental analysis of redundancy in the central metabolism of Geobacter sulfurreducens.
PLoS Computational Biology,
4 (2),
e36 (erratum en 4(3). doi: 10.1371/annotation/67743d4d-2993-4d0c-951b-3f11ce65a8b4.).
Nacional
103 - Segura,D., Noguez,R., Espin,G.. Contaminación ambiental y bacterias productoras de plásticos biodegradables. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 31.
361-372,
Mexico, D.F..
Revisión
104 - Galindo,E., Pena,C., Nunez,C., Segura,D., Espin,G.. Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii.
Microbial Cell Factories,
6 (1),
7.
Nacional
105 - Espin,G., Moreno,S., Segura,D., Moreno,Y.. Alkylresorcinols synthesis and its role in the production of cysts in Azotobacter.
Revista Latinoamericana de Microbiologia,
48 (2),
129-130.
Artículo
106 - Segura,D., Espin,G.. Inactivation of pycA, encoding pyruvate carboxylase activity, increases poly-beta-hydroxybutyrate accumulation in Azotobacter vinelandii on solid medium.
Applied Microbiology and Biotechnology,
65 (4),
414-418.
Artículo
107 - Segura,D., Guzman,J., Espin,G.. Azotobacter vinelandii mutants that overproduce poly-beta-hydroxybutyrate or alginate.
Applied Microbiology and Biotechnology,
63 (2),
159-163.
Artículo
108 - Segura,D., Cruz,T., Espin,G.. Encystment and alkylresorcinol production by Azotobacter vinelandii strains impaired in poly-beta-hydroxybutyrate synthesis.
Archives of Microbiology,
179 (6),
437-443.
Artículo
109 - Trujillo-Roldan,M.A., Moreno,S., Segura,D., Galindo,E., Espin,G.. Alginate production by an Azotobacter vinelandii mutant unable to produce alginate lyase.
Applied Microbiology and Biotechnology,
60 (6),
733-737.
Artículo
110 - Pena,C., Miranda,L., Segura,D., Nunez,C., Espin,G., Galindo,E.. Alginate production by Azotobacter vinelandii mutants altered in poly-beta-hydroxybutyrate and alginate biosynthesis.
Journal of Industrial Microbiology & Biotechnology,
29 (5),
209-213.
Artículo
111 - Peralta-Gil,M., Segura,D., Guzman,J., Servin-Gonzalez,L., Espin,G.. Expression of the Azotobacter vinelandii Poly-beta-Hydroxybutyrate Biosynthetic phbBAC Operon Is Driven by Two Overlapping Promoters and Is Dependent on the Transcriptional Activator PhbR.
Journal of Bacteriology,
184 (20),
5672-5677.
Artículo
112 - Gama-Castro,S., Nunez,C., Segura,D., Moreno,S., Guzman,J., Espin,G.. Azotobacter vinelandii Aldehyde Dehydrogenase Regulated by sigma(54): Role in Alcohol Catabolism and Encystment.
Journal of Bacteriology,
183 (21),
6169-6174.
Artículo
113 - Segura,D., Vargas,E., Espin,G.. Beta-ketothiolase genes in Azotobacter vinelandii.
Gene,
260 (1-2),
113-120.
Artículo
114 - Segura,D., Espin,G.. Mutational inactivation of a gene homologous to Escherichia coli ptsP affects poly-beta-hydroxybutyrate accumulation and nitrogen fixation in Azotobacter vinelandii.
Journal of Bacteriology,
180 (18),
4790-4798.
115 - Segura Gonzalez, Daniel Genaro. Identificacion de genes de Azotobacter vinelandii involucrados en la sintesis de polihidroxibutirato o en su regulacion : analisis de una mutante en el gen ptsP .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
Artículo
116 - Segura,D., Santana,C., Gosh,R., Escalante,L., Sanchez,S.. Anthracyclines: isolation of overproducing strains by the selection and genetic recombination of putative regulatory mutants of Streptomyces peucetius var. caesius.
Applied Microbiology and Biotechnology,
48 (5),
615-620.
*
117 - Segura Gonzalez, Daniel Genaro. Estudios sobre la produccion de doxorrubicina en mutantes de Streptomyce peucetius var. caesius.
Instituto de Investigaciones Biomedicas,
Maestria en Biotecnologia,
UNAM.
Nacional
118 - Santana,C., Segura,D., Sanchez,S.. [Synthesis, function, and evolutionary origin of secondary metabolites produced by micro-organisms].
Revista Latinoamericana de Microbiologia,
36 (2),
139-158.
119 - Segura Gonzalez, Daniel Genaro. Mejoramiento genetico de una cepa de streptomyces griseus productora de estreptomicina.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.