18Feb - 2025
FRONTIERS IN GENOMICS
10:00 AM - 11:00 AM|Alicia Martin.|Analytic & Translational Genetics Unit. Massachusetts General Hospital & Broad Institute. Harvard Medical School USA.
Seminario
Genomics for the world: ancestral diversity enhances genomic discovery, resolution, interpretation, and contextualization.
Resumen de la plática:
Genomic studies are transforming precision medicine, yet their benefits often overlook diverse, underserved populations. Our research shows that embracing ancestral diversity not only addresses this ethical concern but also enhances genomic discovery, resolution, interpretation, and contextualization. Analyzing lung diseases across multiple biobanks, we found consistent genetic effects and improved our understanding of pleiotropy in lung comorbidities. Leveraging the All of Us Research Program’s diversity, we improved polygenic risk scores across various traits, particularly for African ancestry populations and traits with large ancestry-enriched effects. To understand how genetic and environmental factors influence disease, we investigated their impact on the plasma proteome, revealing that many disease-associated proteins are affected by environmental exposures like smoking. This work emphasizes the importance of diverse representation in genomic and multi-omic studies for equitable healthcare and deeper understanding of complex traits and diseases. By integrating diverse ancestries and environmental contexts, we advance comprehensive genomic insights benefiting all populations.
Genomic studies are transforming precision medicine, yet their benefits often overlook diverse, underserved populations. Our research shows that embracing ancestral diversity not only addresses this ethical concern but also enhances genomic discovery, resolution, interpretation, and contextualization. Analyzing lung diseases across multiple biobanks, we found consistent genetic effects and improved our understanding of pleiotropy in lung comorbidities. Leveraging the All of Us Research Program’s diversity, we improved polygenic risk scores across various traits, particularly for African ancestry populations and traits with large ancestry-enriched effects. To understand how genetic and environmental factors influence disease, we investigated their impact on the plasma proteome, revealing that many disease-associated proteins are affected by environmental exposures like smoking. This work emphasizes the importance of diverse representation in genomic and multi-omic studies for equitable healthcare and deeper understanding of complex traits and diseases. By integrating diverse ancestries and environmental contexts, we advance comprehensive genomic insights benefiting all populations.
Auditorio Dr. Francisco G. Bolívar Zapata.
Actualizado 2025-02-18 09:56:48
04-Abril-2025 al 04-Abril-2025
12:00 PM
Dr. David Romero
12:00 PM
Dr. David Romero
Enseñando con entusiasmo: Fede y la Licenciatura en Ciencias Genómicas.
IN MEMORIAM
DR. FEDERICO SÁNCHEZ RODRÍGUEZ
NOVENO ANIVERSARIO LUCTUOSO.
AUDITORIO: "DR. FRANCISCO G. BOLÍVAR ZAPATA"
24-Marzo-2025 al 24-Marzo-2025
12:00 PM
Dra. Marisa S. Otegui
12:00 PM
Dra. Marisa S. Otegui
Membrane remodeling by ESCRT proteins in plant cells
The dynamic flow of proteins to and from the plasma membrane and between organelles is crucial for cellular function, signaling, and development. We study the cellular functions and biophysical properties of ESCRT proteins to uncover the fundamental principles governing membrane remodeling in plants and other organisms. ESCRT proteins are essential for endosomal trafficking of plasma membrane molecules as well as many other crucial cellular events. However, we are still far from understanding how ESCRTs mediate membrane remodeling in the context of all their many cellular functions. Using live imaging, electron tomography, genetics, biochemistry, structural biology, and computational modeling, we analyze endosomal membrane vesiculation in several plant lineages and other organisms to understand the common principles that underlie ESCRT membrane bending. We also have uncovered novel functions of ESCRT proteins in cell plate maturation during cytokinesis, nuclear dynamics, and epidermal cell differentiation. These findings are helping us to elucidate basic mechanisms essential for cell function and plant development, with broader implications for cell biology and plant biotechnology.