Aim of this directory Aim of this directory How to cite this directory Horse (Equus caballus) Cattle (Bos taurus) Sheep (Ovis aries) Pig (Sus scrofa) Home pageThe study of the V genes repertoire is key to understand the origin, structure and function of antibody molecules. This knowledge is important to address questions about the V gene usage under physiological conditions as well as in pathological disorders of the immune system.
Most of our current knowledge of the structure of antibody molecules and their evolution has come from studies in mice and humans. The VH domain plays a predominant role in antigen recognition. The repertoire of human VH domains is encoded by seven VH germline gene families, about 30 D minigenes and six JH gene segments (V BASE). This pool of genes recombines in a random fashion to produce, together with equivalent events in the VL chain, the primary repertoire of antibodies. The resulting repertoire is potentially capable of recognizing any antigen with a low or medium affinity during the primary immune response.
Early studies of sheep (Ovis aries), cattle (Bos taurus) and pig (Sus scrofa) suggested that these species have one small VH gene family and rely on somatic mutation and perhaps somatic gene conversion to diversify the primary repertoire of antibodies (Butler, 1998). Nonetheless, Charlton et al., (2000) analyzed a sheep antibody phage-displayed library and found that the ovine VH repertoire is more diverse than previously thought, being composed of at least 9 VH gene families. This finding stressed the possibility that the diversity encoded in the VH germline genes of sheep evolved to play a more important role in the diversification of the primary antibody repertoire than previous estimations.
Horse (Equus caballus) has been classified within the group of species with limited diversity at the VH germline gene repertoire (Butler, 1998), although the available information on the equine VH repertoire was scarce (Wagner, 2006). Recently, we (Almagro et al., 2006) characterized 46 unique clones chosen at random from a chimeric horse:human antibody library prior to selection with any antigen. Analyses of this information have revealed a perspective of the equine VH repertoire more complex and diverse than previously suggested.
To facilitate the access to the information on the IGHV gene repertoire of horses and other large farm animals, i.e., sheep, cattle and pig, here we offer a directory of the known VH sequences of these species. The sequences were obtained by searching Genbank (July, 2005) with the key words "immunoglobulin heavy chain" AND Equus caballus, Ovis aries, Bos taurus OR Sus scrofa. The multiple amino acid sequence alignments were constructed with the unique (non-redundant) and complete sequences. In the sheep sequences alignment, the rearranged VH genes isolated and characterized by Charlton et al. (2000) were also included. These sequences were not found in GenBank and were obtained by scanning the alignment published by the authors.
Each sequence in the alignment is linked to the original source. In the alignment:
Ig-fold means positions primarily responsible for the Ig-fold conserved features and the hypervariable loops definition (Chothia and Lesk, 1987).
B: residues buried in the protein.
T: residues in turns.
I: Inter-domain residues.
1: H1, 2: H2 and 3: H3.
Numbering(Position) as in (Chothia and Lesk, 1987).
It should be noted that extra gaps in H2 and H3 have been added in the alignment to be able to accommodate some long H2 loops of horses and pig, as well as the long H3 loops of cattle.
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Note: Click on the Genback Accession number (Acc. No.) to retrieve the Genbank record Ig-fold B B B T B B B B 111111111 B BIBI T I IBB 22222222222222 TT B B B B T T B BIBI B 3333333333333333333333333333333333333333333333333333333333 Position 1 10 20 30 40 50 60 70 80 90 100 110 Genbank Name |...|....|....|....|....|....|.ab...|....|....|....|..abcdefghi..|....|....|....|....|....|..abc..|....|....|....|####################################abcdefghijklmno....|....|. Acc. No. DQ125413 1-2 QVQLKESGPGLVKPSQTLSLTCTVSGLSVSS--NGVAWVRQAPGKGLEFVGVIH---------TDGGVDYNPALKSRGSITRDISKSQLYLTLNTLTGEDTAVYYCARHASTGA---------------------------------------------YLYPFDYWGQGILVTVS DQ125414 1-3 QVQLKESGPGLVKPSQTLSLTCTVSGFSLNT--YAVGWVRQAPGKGLEFVGSIY---------SIGSATYNLDLKSRVSITKDTSKSQVYLTVNSLTSEDTAVYYCGRRVNEI---------------------------------------------------DYWGQGILVTVS DQ125415 1-4 QVQLKESGPGLVKPSQTLSLTCTVSGSSSEG--YGVGWVRQAPGRGLEFVGGIT---------NSGSARFNPGLASRASILKNTEKSQVYLTLTDLTGEDTAVYYCAKDSESGF------------------------------------------LYWGHYGVEYWGQGILVTVS DQ125416 1-5 QVQLQESGPGLVKPSQTLSLTCTVSGLSLSS--NTVGWVRQAPGKGLEYVGAIY---------GSASAAYNPALKSRASITKDTSKSQVYLTLNSLTSEDTAVYYCAGGGGGWI----------------------------------------GYDYLGYYDINYWGQGILVTVS DQ125417 1-7 QVQLKESGPGLVKPSQTLSLTCTVSGLSDNS--NAVGWVRQAPGKGLEFVADLT------------DSDSNPALKSRVRITKEPSKSQVRLIMNSLTEEDTAVYYCIHGYYNSF---------------------------------------------MVGAIKYWGQGILVTVS DQ125418 1-10 QVQLKESGPGLVKSSQTLSLTCTVSGASLND--IAVGWVRQAPGKGLEYVGCVY---------DGTGENYNPALKSRASITRDTSKSQVYLALNSLTSEDTAVYYCTGGKGDYG---------------------------------------RYWNSYAEDGITNWGQGILVTVS DQ125419 1-11 QVQLKESGPGLVKPSQTLSLTCTVSGFSLIT--DSVGWVRQAPGKGLEFVGGLS---------SFGSANYNPGLNSRASITKDTSKGQVVLTLNSLTSDDTAVYYCVSFSGQGE---------------------------------------AFAFAYLYYGITYWGQGILVTVS DQ125420 1-13 QVQLQESGPGLVMPSQTLSLTCTVSGLSLVNR-NAVRWVRQAPGKGLEYVGSIY---------GVEERNYNPVLKSRVDITKDTSKSQVYLTLNSVTSGDTAVYYCARNEYGI---------------------------------------------------VEWGQGILVTVS DQ125421 1-14 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--NTVGWVRQAPGKGLEYVGIIY---------GSASTLYNPALKSRASITKESSKSQVYLTLNSLTSEDTAVYYCAGGFSGFD--------------------------------------------WFDRGINYWGQGILVTVS DQ125422 2-1 QVQLKESGPGLVKPSQTLSLTCSVSGLNLNE--DIVGWVRQAPGKGPEYVGSIW---------GDRSPKYNPDVKSRASISKDTSKRQVYLQLNSLSDEDTAVYYCAGGLTILG------------------------------------------VMKDETFVDHWGPGILVTVS DQ125423 2-3 QVQLKESGPGLVKPSQTLSLTCTISGLSLSS--YGVGWVRQAPGKGLEFVGGIR---------SSGSANYNPALKSRASITKDTSQSHVYLTLNSLTSEDTAVYYCAGGTEQRD--------------------------------------------YIDVGVKFWGQGILVTVS DQ125424 2-4 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--VDVGWVRQAPGKGLEYVSWIG-----------RSTSYKPALKSRASITKDTSKSQAYLTLNSLTSEDTAVYYCVGGYADGI--------------------------------------------------DYWGQGILVTVS DQ125425 2-5 QVQLKESGPGLVKISQTLSLTCTVSGLSLSS--NDVGWVRQAPGKGLEYVARIW---------GGANEHYNPALKSRASITKDTSKSQVYLTLNSLTSEDTAVYYCGGTPGFYN--------------------------------------------SAYETFAYWGQGILVTVS DQ125426 2-6 QVQLKESGPGLVKPSQTLSLTCTVSGLLLNS--NCVGWVRQAPGKRLEYVGSIY----------GTLTNYNSALRSRARITSDYSKSQVLLTLNSLTSEDTAVYYCAALDYGVT---------------------------------------------ISRDINDWGQGILVTVS DQ125427 2-7 QVQLKESGPGLVKPSQTLSLTCTVSGLSLTG--SQIAWVRQAPGKGLEYISGSS--------------MYNPALKFRASITKDTSKNQVTLTLNKLTGEDTAVYYCVATAFWGG----------------------------------------------YGGIQYWGQGILVTVS DQ125428 2-8 QVQLKESGPGLVKPSQTLSLTCTVSGLSLTD--YGVGWVRQAPGKGLEFVARID---------SDGSKNFNPALKSRANIIKDTSKSQVYLTLNSLTSEDTAVYYCAGYGYSGR-------------------------------------------YSTPGNLYWWGQGILVTVS DQ125429 2-9 QVQLKESGPGLVKPSQTLSLVCTVSGFSLTD--RGVGWVRQAPGKGLEFVSYIL---------TSGAQDGNPALRSRVSITRDTSLSQVYLTMNSVTGEDTAVYYCGRHGPNLH-----------------------------------------------GTFDYWGQGILVTVS DQ125430 2-11 QVQLKESGPDLMKPSQTLSLTCTVSGFSLSS--YGVGWVRQAPGKGLEFVGGLP---------GSGSADYSPALRSRASITKDTSKSQVYVTLNSLTSEDTAVYYCARFYNWNS------------------------------------------GVVSYTGIDYWGQGILVTVS DQ125431 2-14 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--YGVDWVRQAPGKGLEWVGGIT---------SSGGSGYNPALKSRASITKDTSKSQVYLTLNSLTSEDTAVYYCAGEEEGYV-----------------------------------------YGFTRYYGNYYWGQGILVTVS DQ125432 2-15 QVQLQESGPGLVKPSQTLSLTCSVSGLSLSS--VFVYWVRQAPGKGLEYVGFIGNSGSTIGNSGKTNYNYNPVLKSRASISKDTSKSQVLLTLNSLTSEDTAVYYCAGDNI-----------------------------------------------------KYWGQGILVTVS DQ125433 3-1 QVQLKESGPGLVKPSQTLSLICTVSGFSLSS--DSVGWVRQAPGKGLEFVGVVH----------SSGRARNPALKSRASITKDTSESQVYLTLNSLTSEDTAVYYCAGGRSGYS-----------------------------------------YYAGMVDGINYWGQGILVTVS DQ125434 3-2 QVQLKESGPDLVKPSETLSLVCSVSGQSLSS--YDVGWVRQAPGWGLEFVGVTA---------HYGGIDYNPALKSRASITKDTSKNQLTLILNSLTSEDTAVYYCTGEAQTNC-------------------------------------------DFGVSCLGYWGQGILVTVS DQ125435 3-3 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--YGAGWVRQSPGKGLEYVGGVG---------KSGSSNYNSALKPRASITKDSSKSQISLTLRSLTGEDTAVYYCAIYDSYLR----------------------------------------------GWSVVYWGQGILVTVS DQ125436 3-4 QVQLKESGPGLVKPSQTLSLTCTVSGLSLRG--NVVGWVRQAPGKGLEHVGENV---------SSGGAFYSPALKSRASITRDTSKSQIYLTLNSLTREDTAVYYCAAWKVSSR--------------------------------------------SYLDGINYWGQGILVTVS DQ125437 3-5 QVQLKESGPGLVKPSQTLSLTCAVSGFSLSS--DGINWVRQAPGKGLEFVGSIY---------TSASTIYNPALKSRASITKDTSKSQVYLTLNSLTSEDTAVYYCSGGSE-----------------------------------------------------EYWGQGILVTVS DQ125438 3-6 QVQLQESGPGLVRPAETLSLTCTVSGLDLSS--GTIIWVRQAPGKGLERVGEIV---------GEGSGFYNPALKSRAMITKDTSKNEIYLTLKSLTSEDTAVYYCAGAWGGNY-----------------------------------------YENFFINGVENWGQGILVTVS DQ125439 3-7 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--SCVQWVRQVPGKGLEYVGRIV--------SSGGGLTYNPALKSRASITRDTSKSQVYLTLNSLTDEDTAVYYCTGALNTHY------------------------------------------SSYAGYGIDYWGQGILVTVS DQ125440 3-8 QVQLKESGPGLVKPAQTLTLTCTVSGLHLNSD-AVVGWVRQAPGKGLEFVGGLS---------NTGRANYNPALKSRAIITKDTSKSQVYLTLNSLTSEDTADYFCAGGRMFDY------------------------------------------VYGGYYEIQYWGQGILVTVS DQ125441 3-9 QVQLKESGPGLVKPSQALSLTCTISGFSLTS--HGVGWVRQAPGKGLEFVGSIW---------TTGQTINNPTLKSRVSITRDTGLNQVSLTLNELTSEDTAVYYCAGGAISDY------------------------------------DFFGFRGMFSIYDVQYWGQGILVTVS DQ125442 3-12 QVQLKESGPGLVKPSQTLSLVCTVSGFSLNS--WGVGWVRQAPGKGLEEVGGSQ---------IGGNANYNPALESRASITKDASKSQVYLTLNSLTEEDTAVYYCTGGYNWNL-------------------------------------------GTNRDRITYWGQGILVTVS DQ125443 3-13 QVQLKESGPGLVKPGQTLSLSCTVSGLSLST--NTVGWVRQAPGKGWEYVAALY---------ADADGDYNPVLQSRASITKDTSKNQVFLTLDTLTSEDTAVYYCTGGVFSVP--------------------------------------VGTGYTYYESGILYWGQGILVTVS DQ125444 3-15 QVQLKESGPGLVNPSQTLSLTCFVSGFSLTS--WHVGWVRQAPGKGLEFVGGIP---------VIGEAYYNPVLKSRISITKDTSKSQVYLTLNSLTDEDTAVYACARLRNWYG--------------------------------------------DYYSDMDYWGQGILVTVS DQ125445 4-1 QVQLQESGPGLVKPSQTLSLTCTVSGLSLNS--YDVNWVRQAPGKGLEVVGSIS---------DSGIAVYNPALKSRASITKDTSNSQVYLTLNSLTGEDTAVYYCARGNFAF---------------------------------------------------DYWGQGILVTVS DQ125446 4-2 QVQLKESGPGLVKPSQTLSLTCAVSGFSLRD--AAMGWVRQAPGRGLEYIGSMY-----------IREDYNPALKSRASVTKDTKESRSYLTLNALTSEDTAVYWCVGDVGTG---------------------------------------------------YYWGQGILVTVS DQ125447 4-3 QVQLKESGPGLVKPSQTLSLTCTVSGFSLST--TGVGWVRQAPGKGLEFVGGVP---------SSGSANYNPALKSRCSITKDESKSQVYLTLNSLTSEDTAVYICAGGFYNTL----------------------------------------------DKGINYWGQGILVTVS DQ125448 4-4 QVQLKESGPGLVKPSQTLSLTCTISGFSLTS--ASVDWVRQAPGKGLEFVGGIA---------TSGRANYNPVLKSRATITRDTSKSQVYLTLNSLTGEDTAVYYCAESYYDGV----------------------------------------------GGNYYFWGQGILVTVS DQ125449 4-5 QVQLKESGPGLVKPSQTLSLTCTVSGMSLST--NTVGWVRQAPGKGLEYVGLIY---------GMKSAEYNPALKSRASITKDTSNSQVLLTLNSLTSEDTAVYYCAGGEAWGP---------------------------------------MYSSNEEKNGVEYWGQGILVTVS DQ125450 4-6 QVQLQESGPGLVKPSQTLSLTCTVSGISLTD--YNVDWVRQAPGKGLEFVGGLW---------TNGQSNYNPALKSRARITKDTSKSQVYLTLNSLTSEDTAVYYCEGYGNSWQ------------------------------------------------PPHYWGQGILVTVS DQ125451 4-7 QVQLKESGPGLVKPSQTLSLTCTVSGNDLRS--FGVAWVRQAPGKGLEFVGGVA---------RFGSPYYNPALKSRAIITKDTSKKESVLTLNSVTGEDTAVYWCAGGYGDES-------------------------------------------------WGPWGQGILVTVS DQ125452 4-8 QVQLKESGPGLVKPSQTLSLTCTVSALSLSS--AGVGWVRQAPGKGLEFVAGIV---------GDGGTYANPALRSRASITKDTSKSQVYLTLNMLTSEDTAVYYCAGSLEFSG------------------------------------------WGVMRYGINYWGQGILVTVS DQ125453 4-9 QVQLQESGPGLVKPSQTLSLTCTVSGLSLSS--NAVGWVRQAPGKGLEYVDSIG---------NSESANFNPALKSRASITEDTSKSRVYLTLNSLTSEDTAVYYCAAQYDYFA----------------------------------------GAYGLIPYAIKYWGQGILVTVS DQ125454 4-10 QVQLKESGPGLVKPSQTLSLTCTVSGFPLSS--YGVGWVRQAPGKGLESVGEIA---------SSGSANYNPALKSRASITKDTSKSQVYLTLNSLTSEDTAVYYCTGWGLRL---------------------------------------------------YYWGQGILVTVS DQ125455 4-11 QVQLQESGPGLVKPSQTLSLTCTVSGLSLSS--NVLGWVRQAPGKGLEWIGGIY---------GSASPNYNLTLKARGSITKDTSKSQVYLTLTGMTEEDTAVYYCAGGAPYNY------------------------------------------AGGNIGRMKYWGQGILVTVS DQ125456 4-12 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--YGVGWVRQAPGKGLEFVGGIL---------SSGRANYNPALKSRASITRDTTKNQVYLTLNSLTGEDTSVYYCARSFASGG-------------------------------------------SYYDYAINFWGQGILVTVS DQ125457 4-14 QVQLKESGPGLVKPSQTLSLTCAVSGLPLRD--AAVGWVRQAPGKGLEYIGSMY-----------NEEDYNPDLKSRASVTKDTSKSRVTLTLNSLTSEDTAVYYCVGDGGSG---------------------------------------------------YYWGQGILVTVS DQ125458 4-15 QVQLQESGPGQVKPSQTLSLTCTVTGGSITNKYSSWTWLRQPPGKGLEFIGYIY---------YDGRRYYNPSFKSRTSISRDTSRNEFSLQLSSVTDEDAAVYFCAGDYGYGG-------------------------------------------VWYSDGENYWGQGILVTVS AF288214 PGLVKPGSSVKISCKASGYEFTE--YDIHWVRQANGKGFEWMGSCS--------PHRGEVIQSPNFSGRVTITVDKSTSTVHMELSSLTSEDTAVYYCAVGDSNSL--------------------------------------------YGMIANLYWGQGILVTVS L81159 QVQLKESGPGLVKPSQTLSLTCTVSGFSLSS--YLCSWVRHRSRNRVEYLGELC----------CTCSECEYNPVLKPSTILKTLKSEVICTLNSLNTEDTASSYCASYTGPGI---------------------------------------------VGGEIHYWGQGILVTVS L81157 QVQLKESGPGLVKPSETLSLTCTVSGDYISG--YSYMWLGRSPGTGPDWIGYIS--CCGECINYNPRDPLKSSLVIISKDASKSLKVYLNRRTALTKPVSLAVYGCVRYGDSYD----------------------------------------------YLGINYWGQGILVTVS U15150 QVQLKESGPGLVKPSQTLSLTCTVSGLSLSS--NSVGWVRQAPGKGLEWVGFRS---------GGEEEYYNPALKSRATITEDAAKSQVYLDAEQVTGEATAVYYCAEVYNNYL---------------------------------------------YYGIKELGARGLLVTVS L81158 QVQLKESGPGLVKPSQTLVLTCTVSGLSLGS--DYCSWVRQSPGKGWVGVDRIT-------RHNTDGAIDQYSSPDPMSRVSITQDTQRSKSLSLTAVRGEAVVYCAGFWGYYG--------------------------------------------RGYGYVDHWGQGTLVTVS U17041 QVQLKESGPGLVKPSQTLSLTCTVSGFSLTS--YTVGWVARLQEKDWNMLRLYV---------IVGVQTSTQTLKSRASITRDASKSQVYLTLNSLTVEDTAVYYCARSLPVSG--------------------------------------------NGYSLVNYWGQAS-VTVS Note: The horse sequences accession Nos.: L81155 L81156 L81161 L81160 were not included in the alignment since are incomplete sequences or have structural defects that make them difficult to align.
Cattle (Bos taurus)
Note: Click on the Genback Accession number (Acc. No.) to retrieve the Genbank record Ig-fold B B B T B B B B 111111111 B BIBI T I IBB 22222222222222 TT B B B B T T B BIBI B 333333333333333333333333333333333333333333333333333333333 Position 1 10 20 30 40 50 60 70 80 90 100 110 Genbank Name |...|....|....|....|....|....|.ab...|....|....|....|..abcdefghi..|....|....|....|....|....|..abc..|....|....|....|####################################abcdefghijklmno....|....|. Acc. No. AAC18411 QVQLRESGPSLVKPSQTLSLTCSVSGFSLSS--YASGWVRQAPGKALEWVAAID---------PGGGTYYNPALKSRLSITKDNSKSQVSLSVRSVTPEDTATYYCTTDYSGSC-------------------------------------------YKLTWSVGVWGQGLLVTVS AAC18410 QVQLRESGPSLVKPSQTLSLTCTISGFSLSS--YSVYWVRQTPGKALECLGGIS---------GSGTAGYHPALKSRLSVSKDNSKSQVSLSVSSVTTEDTATYYCAKSTSGAA------------------------------------YSSSCSAGNFASYLDAWGQGLLVTVS AAA68994 SGPSLVKPSQTLSLTCTVSGLSLSD--HNVGWIRQAPGKALEWLGVIY---------KEGDKDYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCATLGCYFV---------------------------------EGVGYDCTYGLQHTTFHDAWGQGLLVTVS AAA68993 SGPSLVKPSQTLSLTCTVSGFSLSN--TVVFWVRQAPEKALEWLGGIC---------SDGNTNFNPALRSRLTITKDNSKSQVSLSVSSVTPDDTATYFCARILGNRG-----------------------------------------CIYGSIPYVTAWGQGLQVAVS AAA68992 SGPSLVKPSQTLSLTCTVSGFSLSS--YEVGWVRQAPGKALEWVGGIS---------AGGWTCLNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYCTKGIYRTY---------------------------------GYGDNTCIGYMYNYASVHAWGQGLLVTVS AAA68991 SGPSLVKPSQTLSLTCTVSGFSLSS--YSVSWVRQAPGKTLEWLGDAS---------NGGIIYYNPALKSRLGITRDNSKSQVSLSLNTITPEDTATYYCAKCSVGDS-------------------------------------GSYACTGRKGEYVDAWGQGLLVTVS S22080 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YALTWVRQAPGKALEWVGGIT---------SGGTTYYNPALKSRLSITKENSKSQVSLSVSSVTPEDTATYYCARSTYGEV--------------------------------------------GDGAIADAWGQGLLVTVS AAC71042 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--NGVGWVRQAPGKALEWVGGID---------NDGDTYYNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYCANSCYSGY-------------------------------------GYGCGYGYGYDYVDAWGQGLLVTVS AAC71041 QVQLRESGPSLVKPSQTLSLTCTISGFSLSS--YAVGWVRQAPGKALEWLGGIS---------SGGSTCLNPALKSRLSITKDNSKSQVSLSVSSVTTEDTATYYCTCYSGYGY---------------------------------------GYGYAYGYDYVDAWGQGLLVTVS AAC71040 QVQLRESGPSLVKPSQTLSLTCTVFGFSLSD--NSVGWVRQVPGKALEWLGVIY---------SGGSTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCARDCYSDY------------------------------------GNGYGCGYGYGSYVDAWGQGLLVTVS AAC71039 QVQLRESGPSLVKPSQTLSLTCTASGFSLSD--KAVGWVRQAPGKALEWLGGID---------TGGSTGYNPGLKSRLSITKDNSKSQVSLSVSSVTTEDSATYYCTTVHQIFC--PDGYSYGYGCGYGYGCSGYDCYGYGGYGYGGYGGYSSYSYSYSYEYYGDAWGQGLLVTVS AAN07165 QVQLRESGPSLVKPSQTLSLTCTVSGFSLST--YAVGWVRQAPGKALEWVADIS---------RSGITYYNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYCTKCSACPY----------------------------------VECYCYNAPWSNTQYVDAWGQGLLVTVS AAN60017 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSD--YRVGWVRQAPGKALEWLGVMY---------NDGTTAYRPALLSRLRITRDNSKNQVALSLSSVTTEDTATYYCTRIIPVCT-----------------------------------------WPYGDYGCYDILGQGLLVTVS AAA98664 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSN--YVVTWVRQAPGKRLECLGSID---------GGGGTMYNPALKSRLTITKDNSKSQVSLSLSSVTSEDTATYYCVKLYGGHG------------------------------------YGSSGCISLGEGYVDAWGQGLLVTVS AAA98660 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSD--NSVGWVRQPPGKALEWLGVIY---------AGGSTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCARVGFCYS-------------------------------------GYGYGYGCGYGYGDAWGQGLLVTVS AAA98657 QVQLRESGPSLVKPSQTLSLTCTASGFSLSD--KAVGWVRQSPGKALEWLGGID---------TGGSTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCARLMVMVM------------------------------------------VIVMDYYVDAWGQGLLVTVS AAA98655 QVQLRESGPSLVKPSQTLSLTCTVSGFSLTN--YAATWVRQAPGKALECLGSVV---------GSGSTGYNPALKSRLSITKDSSKNQVSLLVMSVTSKDTAIYYCLRHYYNNN---------------------------------------NWDGCGHHWGFDAWGQGLLVTVS AAA98654 QVQLRESGPSLVKPSQTLSLTCTISGFSLSS--YGVNWVRQAPGKALECLGGIS---------SGGNTGYNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYCAKSSLGWA---------------------------------------YGTDYYQSYCVDAWGQGLLVTVS AAA98653 QVQLRESGPKLVKPSQTLSLTCAISGFSLSN--YAVDWVRQAPGKALEWLGSIG---------GDGRTCLNPALKSRLSITEDNSKSQVSLSVSSVTTEDTATYYCAKKTTSGN---------------------------------------GSGCNLGINYVDAWGQGILVTVS AAA98648 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YAVGWVRQLPGKALEWVGDIS---------KAGSTCLNPALKSRLIITKDNSKSQVSLLMSAVTPEDTATYYCARGGGSWY-----------------------------------RIDECIRTGYGKEQVDAWGQGLLVTVS AAA98647 QVQLRESGPSLVKPSQTLSLTCTVSGFSLNN--YAVTWVRQAPGKALECLGGID---------GGRSTGYNPALKSRLSITKDNSKSQVSLSVVSVTPDDTATYYCAKLFGIGD--------------------------------GVADYGCHGYGYRYENYIDVWGQGLLVTVS AAA98646 QVQLWESGPSLVKPSQTLSLTCTVGGFSLDD--YAIEWVRQAPGKALECLGGVS---------GGGITDYNPALRSRLTIMKDDSKNQVSLSLSSVTLEDTATYYCARFTHDST------------------------------------WGYGCYYRAGDYYINAWGQGLLVTVS AAB01187 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSN--WGVDWVRQAPGKALECLGGVS---------YDGKTATAQPLKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCAKSGYDYG---------------------------------GYGCHRSSYVYNDGPYIDAWGQGLLVTVS AAB01186 QVQLRESGPSLVKPSQTLSLTCTVSGFSLRS--AGVNWVAEAPGKALEWVGFIG---------GSGRTWYNPALKSRLSITMDNSKSQVSLSVSSVTPEDTATYYCARPNL-----------------------------------------------------ASWGQGLLVTVS AAB01185 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YGVGWVRQAPGKALECLGGIS---------SGGSTAYNPALESRLSITKDNSKSQFSLSLSSVTIEDTATYYCAKGGAYAS--------------------------------DGGRCANWGSGVGSGCCVDAWGQGLLVTVS AAB01184 QVQLRESGPSLVKPSQTLSVTCTASGFSLSD--KAVGWVRQAPGKALEWLGGID---------SGGSTGYNADLKSRLSITKDNSKSQVSLSVSSVTTEDTATYYCAKNLRSDY---------------------------------------CCGSNNGCGYVDAWGQGLLVTVS AAB01183 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSD--YGVGWVRQAPGKALECLGGIN---------SNERTGYNPALISRLSITKDNSKSKVSLSLSSVTTDDTATYYCAKSSGWSS-------------------------------------GCSYGVGYTWAYVDAWGQPLLVTVS AAB01182 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--GDVGWVRQAPGKALECLGGIG---------SGGSTVFNAALKSRLTITKDNSKNQVSLSLSSVTTEDTATYYCARDVGRRS-----------------------------------------DDYFSCSHVDAWGQGLLVTVS AAB01181 QVQLRESGPSLVKPSRTLSLTCTVSGFSLSS--YAVGWVHQAPGKALECLGGIS---------GRGTADYNPALKSRLSITRENSKSQVSLSLSSVTTEDTATYYCTKSTGTNA------------------------------------DDCDDFFGDAYAYVDAWGQGLLVTVS AAB01180 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YGVGWVRQGPGKALECLGNIS---------GGGTTGYNPAQKSRLSISMDKSKSQVSLSLSSVTTEDTATYYCAKSSVYGY------------------------------------DSYGCWNGGNDYYVDAWGQGLLVTVS AAB01179 GPKLVKPSQTLSLTCTTSGFSLSS--YTVGWVRQTPGKALEWVGGIE---------GDGDTCYNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYCARLTGDYV-----------------------------------YGDGGCYAYDYNYHVDAWGQGLLVTVP AAC71047 QVQLRESGPSLVKPSQTLSLTCTVSGISLSS--NTVVWVRQAPGKALEWVGTMT---------AGESVYYNSALRSRLSITKDNSKSQLSLSVSSVTPEDTATYYCAKCGAGYG-----------------------------------------MYTYGYAYGDVWGQGLRVTVS CAA10187 QVQLRESGPSLGKPSQTLSLTCTTSGFSLTN--YGVTWFRQAPGKALEWLGEIN---------NNGFIDRNPGLRSRLSITRDNSKSQVSLSLSRVTPEDTAVYYCSKDLCGYD------------------------------------YRNYGCDPYGPSYVDAWGQGLLVTVS CAA10186 QVQLRESGPSLVKPSQTLSLTCTTSGFSLTS--YGVTWFRQAPGKALEWLGEIN---------NNGFMDRNPDLRSRLNITREISLSQVSLSLSRVTPEDTAVYYCSKDLCGID------------------------------------YRNYGCDPYGPSYVDAWGQGLLVSVS CAA10188 QVQLRESGPSLVKPSQTLSLTCTVSGFSLNN--QTVTWVRQAPGKALEWLGSIN---------SGGRTDYNPALKSRLSITKDNSRSQVSLSLFGVTTGDAATYYCGHCYRGRG-----------------------------------------AGYECTYGIHAWGQGLLAPVS CAA10185 QVQLRESGPSLVKPSQTLSLTCTLSGVSSTQ--YDVTWVRQAPGKTWEWLGEID---------RNGKAYYNRALKSRLSITRGNSTSQVSLTLSSVRLEDTATYYCGRIWL-----------------------------------------------------DTWGQGLLVTVS CAA10184 QVQLRESGPSLVKPSQTLSLTCTLSGVSSTQ--YDVTWVRQAPGKTWEWLGEID---------RNGKAYYNRALKSRLSITRGNSTSQVSLTVTSVRLEDTATYYCGRIWL-----------------------------------------------------DTWGQGLLVTVS CAA10183 QVQLRESGPSLGKPSQTLSLTCTVSGVSLSR--YDVTWVRQAPGKTLEWLGEMA---------SDGKTYYPPALKSRLSITKDNSKSQVTLSLSSVTPEDTATYYCGKIWL-----------------------------------------------------DTWGQGLLVTVS CAA10182 QVQLRESGPSLVKPSQTLSLTCTVSGRSLSS--YDITWVRQAPGKTLEWLGEID---------KDGKTYYNPALKPRLTITKDNSKSQVSLSLSSVTPEDTATYYCGRIWI-----------------------------------------------------DTWGQGVLVIVS AAC71046 QVQLRESGPSLVKPSQTLSLTCTVYGFSLSD--YAVGWVRQAPGKAREWIGDAA---------ADGNTLYNPDLKSRFSITKDNSKNQVSLSVSSVTPEDTATYYCTKSSRERH---------------------------------------YASSSSLAGYIDLWGQGLRVTVS AAC71045 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YAVNWVRQAPGKALEWVGGIT---------VGGSTCLNPALKSRLTITKENSKSQVSLSVNNVTPEDTATYYCARNYAPVA------------------------------------NSWYGCHDYGVGDLDAWGQGLLVTVS AAC71037 QVQLRESGPSLVKPSQTLSLTCTASGFSLSD--KAVGWVRQAPGKALEWLGSID---------AAGSTGYNPGLKSRLSITKDNSKSQVSLSVSSVAAEDSATYYCTTVHQKTTRKTCCSDAYRYDSGCGSGCDCCGADCYVFGACTFGLDSSYSYIYIYQWLVDAWGQGLLVTVS AAC48520 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSE--YNVYWDRQAPGKALEWLGIRW---------NNGVTDYNPTLESRLSITTDNSKSQVSLSLSSVTTEDRATYYCTRNG------------------------------------------------------DTWGQGLLVTVS AAC48519 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YAVGWVRQAPGKALEWIGGIS---------AGGITYYSPALKSRLSITRDNSKSQVSLSINSATPEDTATYYCAKEEDSYG--------------------------------GSGCSTVHPIYACLAAHVDAWGQGLLVTVS AAC48518 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--NGVIWVRQAPGKALEWLGGIC---------GGGSISFNAVMKSRLSITKDNSKSQVFLSVSSVTPEDTATYYCARDYAVGG------------------------------------AGCYGVGYAYGYYVDAWGQGLLVTVS AAC48517 QVQLRESGPSLVKPSRTLSLTCTVSGFSLSS--YGVDWVRQAPGKALECLGGIS---------SRGSTAYNSALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCAKKTGSWV----------------------------------NSRFGCSGGGFSDDYVDAWGQGFLVTVS AAC18616 QVQLRESGPSLVKPSQTLSLTCTVSGFSLNS--WGVGWVRQAPGKALECLGDIS---------SNGYTGYKPALKSRLSITWDNSQSQVSLSLSSVTSDDTATYYCVKSGSIGF-----------------------------------SGGGCGVGGVAYAYVDAWGEGLRVTVS AAC18615 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSG--NSVGWVRQTPGKALEWLGNMD---------GIGTTDYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCAKCTGAYC-----------------------------------------WRFDDAYGYDDWGQGLLVTVS AAC18413 QVQLRESGPILVKPSQTLSLTCTISGFSLSS--YAVDWVRQAPGKALEWLGGIN---------NTGRTGYNAALKSRLSIAKDNSRSQVSLSVSSVTTEDTATYYCAKCTFGGD----------------------------------------RGGCGYADAYDAWGQGLLVTVS AAC18412 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YAVLWVRQAPGKTLEYVGGVD---------ADGGARYNPTLKSRLSITKDNSKSQVSLSVSSVTTEDTATYYCAKNSLFNG------------------------------------------DGDACGRLEVWGQGLLVTVS AAB00211 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YAVSWVRQAPGKALEWLGVIY---------SGGNTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYC AAB00210 KVQLQESGPSLVKPSQTLSLTCTASGFSLSS--YAVGWVRQAPGKALEWVGGIS---------SGGSTCLNPALKSRLSITKDNSKSQVSLSVSSVTTEDTATYYC AAB00209 QVQLRESGPSLVKPSQTLSLTCTISGFSLSS--YAVGWVRQAPGKALEWVGGIS---------SGGSTCLNPALKSRLSITKDNSKSQVSLSVSSVTTEDTATYYC AAB00207 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YGVGWVRQAPGKALECLGGIS---------SGGSTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYC AAB00205 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSD--NSVGWVRQAPGKALECLGGIS---------SGGSTGYNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYC AAB00204 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--NGVVWVRQAPGKALEWLGGIC---------SGGSTSFNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYC AAB00201 KVQLQESGPSLVKPSQTLSLTCTVSGFSLSS--YGIHWVRQAPGKALEWLGDIS---------SGGSTGYNPGLKSRLSITKDNSKSQVSLSLSSLTPEDTATYYC XP_593518 KVQLQESGPSLVKPSQTLSLTCTTSGFSLTS--YGVSWVRQAPGKALEWLGGID---------SGGSTGYNPGLKSRLSITRDNSKSQVSLSVSSVTPEDTATYYCAK XP_583349 QVQLRESGPSLVKPSQTLSLTCTVSGFSLSS--YAVSWVRQAPGKALEWLGDIS---------SGGSTGYNPALKSRLSITKDNSKSQVSLSVSSVTPEDTATYYCAK
Sheep (Ovis aries)
Note: Click on the Genback Accession number (Acc. No.) to retrieve the Genbank record Ig-fold B B B T B B B B 111111111 B BIBI T I IBB 22222222222222 TT B B B B T T B BIBI B 333333333333333333333333333333333333333333333333333333333 Position 1 10 20 30 40 50 60 70 80 90 100 110 Genbank Name |...|....|....|....|....|....|.ab...|....|....|....|..abcdefghi..|....|....|....|....|....|..abc..|....|....|....|###################################abcdefghijklmno....|....|. Acc. No. S54249 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTV--NAVGWVRQAPGKVPEWLGSIS---------TDGSTSYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARRTFSGG-----------------------------------------GFAVGDNIDYWGPGLLVTVS S54247 QVRLQESGPSLVKPSQTLSRTCTVSGFSLTS--NAVNWVRQAPGKALEWVGAVH---------TDGTTRYNPALKSRLSITRDTSKSQLSLSVSTVRTDDTATYYCTMSACGYN---------------------------------------------RGCIVNWGPGLLLTVS S54246 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVAWVRQAPGKALEWLGGIW---------RDGKTNYDPAFQSRLSITRDTSKSQVSLSLSSVTTDDTAVYYCTEIAYYGK----------------------------------------------FEIYSWGPGLLVTVS S54245 QVQLQGSGPSLVKPSQTLFLTCTVSGFSLTS--YAVNWVRQAPGKALEWVGNIL---------NDGNTYYNPALKSRLSISRDTSKSQVSLSLSSVTTEDTAVYYCARGGIYYS--------------------------------------------TWTGINYWGPGLLVTVS S54244 QVRLQESGPSLVKPSQTLSLTCTVSEFSLTT--YGVGWVRQAPGKALEWLSYIY---------NNGDTDYNAALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCTRDTSARS----------------------------------------GYANGLGGVDFWGRGLLVTVS S54243 QVRLQESGPSLVKSSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKAPEWVAGIH---------NSGSIGYNPALKSRLSITRDTSKSQVSLSLSSVTAEDTPMYYCARDYSGCG------------------------------------------RSAVACIDYWGPGLLVTVS S54242 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVHWVRQAPGKVPEWLGGIA---------TGGSTFYKPALMSRLSITRDSSKSQVSLSLSSVTSDDTAVYYCARDIDGTV--------------------------------------------NVWDIETWGPGLLVTVS S54241 QVRLQESGPNLVKPSQTLSLTCTVSGFSLTS--KAVDWVRQAPGKVPEWLGGIS---------GRGSTYYNSALKSRLSITRDTSESQLSLSLSSVTADDTAVYYCVRGDRSIG------------------------------------------YYGSGWIDYWGPGLLITVS S54240 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVDWVRQAPGKVPEWLGGVS---------SDGSTYYNPALKSRRSITRDASKSQVSLSLSSVTTEDAAVYYCARTWYSGC--------------------------------------------ACGSIDYWGPGLLVTVS S54239 QVQLEESGPSLVKPSQTLSLTCTVSGFSLTS--NNVGWVRQAPGKALEWVGDIY---------AGGSKEYSPALKPRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARDQPSSG--------------------------------------------VFGDYDYWGPGLLVTVS S54238 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NDVVWVRQAPGKVPEWLAQIS---------PRGNTYYNQALKSRLSITRDTSKSQVSLSLNSVTTEDTAVYFCVRCSSESC-------------------------------------------WHATGIDYWGPGLLITVS S54237 QVRLQESGPSLVKPSQTLTLTCTVSGFSLTS--NAVGWVCQAPGRVPECLGGID---------TYGNTGYNPALKSRLSIARDTSKSQVSLSLSSVTPEDTAVYYCARFSGGSG---------------------------------------YAWGVGTSGIDYWGPGLLVTVS S54236 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKALEWVGFIY---------TRGSIYYNPAMKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARDSGYGY-------------------------------------------AYGCSIDYWGPGLLVTVS S54235 QVQLQESGPCLVKPSQTLSLTCTVSGFSLTS--RGVNWVRQAPGKSLEWVGGIW---------SDGSTDYKPALKSRLSITRDTSRSQVSLSLSSVTSEDTAMYYCAKSYFE----------------------------------------------------YWGPGLLVTVS S54234 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTT--YSVGWVRQAPGKALEWLGGIE---------NDGCAGYHPALKSRLSITRDTSKSQVSLSLSSVTSEDTAMYYCVRSFFGGK-----------------------------------------------YWGYWGPGLLVTVS S54233 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVPQAPGKVAEWLGGMN---------NGGTYYNPALKSRLSITRDPSKSQVSLSLSSVTSEDTAVYYCARAYRGYL--------------------------------------------YCHHIDYWGPGLLVTVS S54232 QVQLQESGPSLVKPSQTLSLTCTVSRFSLTS--NVVGWVRQPPGKALEWLGIFN---------SDGNIFLNSALKSRLSVIRDIAESQLSLSLSSVSAEDTAVYYCASFYAREY------------------------------------------IYDYWSIHYWGPGLLVTIS S54231 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--GAVGWVRQAPRKALEWVSSIG---------TSGGLYYNPALKSRLSITRDTSKSQVSLTVSGVTTEDAAVYYCARISSGGA---------------------------------------------PYSIDYWGPGLLVTVS S54230 QVRLQESGPSLVKPYQTLSLTCAVSGFPLSN--YGVEWVRQAPGKALEWVGEIK---------DIGTAEYNPALKSRLTISRETSKSQVSLSLSSVTIDDAAVYYCAKNGYRDG---------------------------------------AGRYYGPGFIEYWGPGLLVTVS S54229 QVRLQESGPSLVKPSQTLSLICTVSGLSLSS--YGVTWVRQAPGEAPEWLGATR---------KNGDTNYSPTLKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCVGGWSWAL---------------------------------------------VYEVEYWGPGLLVTVS S54228 QVRLQGSGPSLVKPSQTLSLTCSVSGLSLTN--HGVGWVRQAPGKALEWLGCLY---------NDGDTGYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTALYYCATRNGGYY----------------------------------------SRGAVLGYIDYWGPGLLVTAS S54227 QVRLQESGPSLVKPSQTLSVTCTVSGFSLTN--YAAGWVRQAPGKALEWLGGIH---------TNGGGNLNPALKSRLSITRDTSKSQVSLSLSSVASEDTAVYTCVRFGSGWA--------------------------------------------AADGIDYWGPGVLVTVS S54226 QVQLQESGPSLVKPSQTLSLTCTVSGFSFSN--NAVGWVRQAPGKTLEWVGNIW---------SDGSTYYNPALKSRLSITRDTSKSQVSLSLSSVSIDDTAVYYCARDENSGW-------------------------------------------TYVGGIDYWGPGLLVTVS S54225 QVQLQESGPSLVKPSQTLSLTCTVSGFSLAS--NDITWVRQAPGRALEWITCLA---------RDGRTWYNPALKSRLSITRDTSKSQVSLSLRSVTTEDTAVYYCGRDGRSWA----------------------------------------------SDIDYWGPGLLVTIS CAD45084 QVHLQELGDRLRKPLQTLSLTCTVSGFSLTS--YGVDWVRQAPGKALEWVGVIY---------SGGSTYYHPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAAAYSGYD---------------------------------------YVYGSYYYNGDVWGGGL CAD45083 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVDWVRQAPGKALEWVGVIY---------SGGSTYYHLALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAA CAD45082 QVQMQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVDWVRQAPGKALEWVGVIY---------SGGSTYYHPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAA CAD45081 QVQLQESGPSLVKPSQTLSLTCTVFGFSLAS--YGVDWVRQAPGKALEWVGVIY---------SGGSTYYHPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAAAYRVII----------------------------------------MFTVPYYGVDVWGRGL CAD45080 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVDWVRQAPGKALEWVGVIY---------SGGSTYYHPALKSRLSITRDTSKSQVSLSLSSVTTEDAAVYYCAA CAD45079 QVQLQESGPSLVKPSQTLSLTCTFSGFSLTN--YDVAWVRQAPGKALEWVGNIY---------DDGSTDYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARAIW----------------------------------------------------DYWGPGL CAD45078 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVNWVRQAPGKALEWVGVIY---------SGGSTDYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARVLT------------------------------------------------------WGRGL CAD45076 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWLGGID---------NDGDTGYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAKDYSSYY--------------------------------------------SGYGIDYWGPGLLVTVS CAD45075 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTC--YDVNWVRQAPGKALEWVGNIY---------SGGSTYYNPALKSRLSITRDTSRSQVSLSLSSVTTEDTAVYYCARDLYSGY-----------------------------------------GYRYDYGVDVWGRGL CAD45074 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWVGNIY---------SRGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARGPAII--------------------------------------------------DYWGPGL CAD45073 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTT--YGVTWVRQAPGKALEWLGGID---------NDGDTGYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAMYYCANYYSGYG-----------------------------------------YAYGPNYIDYWGPGL CAD45072 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKAPEWVGGID---------NDGDTGYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARGWWLWS------------------------------------------------IDYWGPGL CAD45070 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTN--NAVGWVRQAPGKVPEWLGGID---------NDGDTGYHPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCASAYGYAY-------------------------------------------GWGYYIDYWGPGL CAD45068 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKTLEWVGNIW---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARVGGYGY---------------------------------------------ALGLDYWGPGL CAD45067 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YDIGWVRQAPGKALEWVGNIY---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAR CAD45065 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWVGDIY---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTGEDTAVYYCASGNDSGY-------------------------------------------DYLYGVHVWGRGL CAD45064 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWLGGID---------NDGDTDYNSALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAR CAD45063 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWVGDIY---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAR CAD45062 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWLGGID---------NDGDTGYDPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCASYYSDYG---------------------------------------YAYGFESYYIDYWGPGL CAD45061 QVRLQESGPSLVKPSQTLSPTCTVSGFSLTS--NAVGWVRQAPGKALEWVGNIY---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAREDYYSG-------------------------------------YGYAYGYPYYGVDVWGRGL CAD45060 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWLGGIS---------SGGSTHYNPALKSRLSITRDTSKSQLSLSLSNVTTEDTAVYYCAKGPHYSG--------------------------------------YGYAYGYFYGVDVWGPGL CAD45059 QVRLQESGPSLAKPSQTLSLTCTVSGFSLTS--NAVCWVRQAPGKAPEWVGGID---------NDGDTGYNPALKSRLIITRDTSKSQVSLSLSSVTTEDTAVYYCARTIDGYY---------------------------------------SGYGLDWLDIDYWGPGL CAD45058 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKALEWVGNIY---------SGGSTYYNPALKSRLNITRDTSKSQVSLSLSSVTTEDTVVYYCARQHYIGY-------------------------------------------GYAYEIDYWGPGL CAD45057 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKALEWVGDSY---------SGGSTYYNSALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAR CAD45056 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWVGNIY---------SGGSTYYNPALKSRLSITRDTSKSRVSLSLSSVTTEDTAVYYCARVDYTGY---------------------------------------GYAYGLIYGVDVWGPGL CAD45053 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPGKALEWLGGID---------NDGDTGYVPALKSRLSIARDTSKSQVSLSLSSVTTEDTAVYYCAGYAYGSG----------------------------------------------YGVDVWGRG CAD45052 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWARQAPGKALEWLGGID---------NDGDTGYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARGSYYSG---------------------------------------WGYAYGHYYIDYWGPGL CAD45051 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVEWVRQAPGKALEWLGSID---------NDGDTGYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARASSKTV-------------------------------------GGYGYTYGIYYIDYWGPGL CAD45049 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKVPEWLGGIS---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAR CAD45047 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQAPGKVPEWLGGIS---------SGGSTYCNPALKSRLSITRDTSKSQVSLSLSSVTSEDAAVYYCASQPRYYS---------------------------------------GWGYAYDYYIDYWGPGL CAD45046 QVRLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQTPGKALEWLGGID---------NDGDTGYNPALKSRLAITRDTSKSQVSLSLSSVTTEDTAVYYCASSLIAIP---------------------------------------------LAHIDYWGPGL CAD45045 QVRLQESGPSLVKPSQTLSLTCTVPGFSLTS--YGVGWVRQAPGKALEWVGNIY---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCAREIVYSD------------------------------------------YGLYFYIDYWGPGL CAD45043 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YDVDWIRQAPGKALEWVGNID---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCARGYYNGY----------------------------------------GYAYAYSPLICWGPGL AAN07166 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--YGVGWVRQAPREALEWVGYTN---------PGGTVLYNPALKSRLSITRDTSLSQVSLSLSSVSTEDTAVYYCVRYYGWDV-----------------------------------------------AYDYWGPGLLVTVS AAD52606 QVQLQESGPSLMKPSQTLSLTCSVSGFSLTS--YSVVWVRQAPGKALEWVGAIY---------SDGSASYNPALKSRLSVTRDTSKSQVSLSLSSVTTEDTAVYYCARDRFSVY------------------------------------------GHAYLSIDYWGPGLLVTVS AAD52605 QVQLQESGPSLVKPSQTLSLTCTVSGFSLAS--NAVGWVRQAPGKVPEWLCDVS---------TGEITYYNPALKSRLSITRDTSKSQVSLSLNSVTSDDSAVYYCARELSGK---------------------------------------------------YWGPGLLVTVS AAD52604 QVQLQESGPSLVKPSQTLSLTCTVFGFSLTS--NAVGWVRQAPGKVPEWLAAIG---------STGSIYYAPALESRLSITRDTSKSQVSLSLSNVTSEDTAVYYCARESDWSY-----------------------------------------MFDSRSGVDGWGRRLLVTVS AAD52603 QVQLQESGPSLVKPSQTLSLTCTVSGFSLDS--YAIGWVRQAPGRVPEWLGGIS---------TSGSMYYNPTLKSRLSVTRDPSKSQVSLSLSSVTTDDTAMYYCAREVTAAL------------------------------------------------IDYWGPGLLVTVS AAD52602 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTT--NDVDWVRQAPGKVPEWLGEIE---------SGGDTVYNPSLRSRLSITRDASKSQVSLSLSSVTTEDTAVYYCARWVNSYH-----------------------------------------------TLDIWGRDLMVTVS AAD52601 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTY--NAVHWVRQAPGKVPEWLGSIS---------SGGSTYYNAALKSRLSITRDTSKSQVSLSLSRVTTEDSAVYYCASDDGDGV-------------------------------------------VDISYIHYWGPGLLVTVS AAD52600 QVQLQESGPSLVKPSQTLSLTCTVSGFSLYS--YDVQWVRQAPGKALEWLAWIT---------TTGSTAYNPALKSRLSITRDTSKSQVSLLLSSVTTEDTAVYYCGRDVGSDA-------------------------------------------------VMWGRRLLVTVS AAD52599 QVQLQESGPNLVKPSQTLSLTCTVSGFPLTT--CGVTWVRQAPGKALEWLGGID---------SDGDVGCNQALKSRLSISRDTSKSQVSLSVSSVTIEDTAVYYCARNTYAEH---------------------------------------------------WGPGLLVTVS AAD52598 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTT--VGVNWVRQAPGKALEWLAFIY---------SDGSRGYNPALKSRLSIARDTSNNSVSLSLSSVTTEDTAMYYCGRMLSIYG---------------------------------------------DAHGSHWGPGLLVTVS AAD52597 QVQLQESGPSLVKPSQTLSLTCTVSGLSLTN--YAVGWVRQAPGKALEWVGAIW---------SSGNTDYNPALKSRLGITRDTSKNQVSLSLSSVTTEDTAVYYCVRHWYDNT-------------------------------------------YGPAYIDYWGPGLLVTVS AAD52596 QGQLQESGPSLVKPSQTLSLTCTVSGFSLTS--FAVVWVRRAPGKALEWLGDVR---------NNGDIDYNPALKSRLSITRDTSKSQVSLSLNSVTSEDTAVYYCARSVVAGD--------------------------------------------------YWGPGLLVRLS AAD52595 QVQLQESGPTLVKPSTTLSLTCTVSGFSFVN--YGVTWVRQAPGKPPEWLGNIF---------TYGSTTYNPALKSRLSITRDTSKSQVSLSLSNMTTEETAVYHCVRNAYGGR--------------------------------------------FDLESDYWGPGLLVTVS AAD52594 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVHWVRQAPGAALEWLGSVD---------HDGDTDYNPALKSRLDITRDTSDKQISLSLSSVTTEDTAMYYCARDTCWGD-------------------------------------------HGVDCIDYWGPGLLVTVS AAD52593 QVQLQESGPSLVKPSQTLSLTCTVSGFSLST--YGVGWVRQAPGRALEWVGISY---------NDGDTNYNPALRSRLSITRDTSKSQVSLSLSSVTAEDTAMYYCARERLYAM----------------------------------------------YDIDYWGPGLLVTVS AAD52592 QVQLQESGPSLVNPSRTLSLTCTVSGFSLWN--HAVGWVRQAPGKEPKWLAGIS---------SSGNTDYNPALKSRLSITRDTSKSQASLSLSSVTIEDTAVYYCVRSLVTNI---------------------------------------------GWTVDYWGPGLLVTVS AAD52591 QVQLQESGPSLVKPSQTLSLTCTASGFTLTS--INVGWVRQAPGKVPEWLGTIN---------SAGNTYYNPALKSRLEIVRDTSKNQFSLSLSSVTTEDTAVYYCARLYALAI---------------------------------------------TMPIDYWGPGLLVTVS AAD52590 QVQLQESGPSLVKPSQTLSLTCTVSGFSLAS--YAVNWVRQAPGKALEWVGGIT---------SGGYKYYNPALKSRLSITRDTSKSQVSLALSSVTTEDTAAYYCVRGYGGIY---------------------------------------------------WGPGLLVTVS AAD52589 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTNYGVGVDWVRQAPGKALEWLGTIY---------SGGSTYYNPALKPRLSITRDTTKSQVSLSLSSVTTEDTAVYYCKRGNG----------------------------------------------------DYWGPGLLVTVS AAD52587 QVQLQESGPNLVKPSQTLSLTCTVSGFSLSS--YAVCWVRQAPGKTLEWIGGIF---------CGVTTIYNPALKSRLSITKSTSKNQFSLSLSSVTSEDTAVYHCARDRYHLV-------------------------------------------IWLCVGDYWGPGLLVTVS AAD52586 QVQLQESGPSLVKPSQTLSLACTVSGFSLTS--NSVGWVRQAPGKVPEWLGGIS---------RSGSTYYNPALKSRLTITRDTSKSQVSLSLSSVTSEDTAVYYCADSLYVHN------------------------------------------------TDYWGPGLLVTVS Note: The ovine sequences below are not in Genbank. We scanned them from Charlton et al., (2000) Ig-fold B B B T B B B B 111111111 B BIBI T I IBB 22222222222222 TT B B B B T T B BIBI B 333333333333333333333333333333333333333333333333333333333 Position 1 10 20 30 40 50 60 70 80 90 100 110 Genbank Name |...|....|....|....|....|....|.ab...|....|....|....|..abcdefghi..|....|....|....|....|....|..abc..|....|....|....|###################################abcdefghijklmno....|....|. Acc. No. H6 QVQLQGSGPSLVKPPETLSLTCTVSGFSLER--SYISWVRQAPGKPLEYLGVID---------DDGTPRYVSALKSRLSITKDTSKSQVFLSLSSVKPEDASMYYCVKSSGGGA-----------------------------------------SNTGVGYMDYWGPGLLISVL H3 QVQLQESGPSLVKPSQTLSLTCTFSGFSLSN--YELGWVRQAPGKALEWVGYKN---------NRGSEDYNPALKSRLRLTTDTSKNQVSLSLSSVIIEDTDVYYCARAGYGWF----------------------------------------------YGFDAWGRGLLLTVS H69 QVQLQGSGPSLVKPSQTLSLTCTVSGFSLTG--YGVLWARQAPGKALEWVGNIL---------GDGRTYYNPALKSRLSITRDTSKSQVSLSLSSVETEDTAVYYCRGQ------------------------------------------------------FVWGRGLLVSAS H39 QVQLQESGPSLVKPSQTLSLTCTVTGLFLND--TVIGWVRQTPGKVPEWVGGVV---------SDGRPYYNRVLKSRLRIRRDTSENQVSLSLRSVTLDDTAVYYCVRDQGGAT-----------------------------------------GLGFYHYVDVWGPGLLITAS H1 QVQLQESGPSLVKPSQTLSLTCTVSGLSLSA--YGVVWVRQAPGKALEWVGEID---------DTGNKYYNPALKSRLSFTRDTSRNQVSLSLTSVTTEDSAVYYCGGGRIFDS-------------------------------------------------DYWGPGLLVTVS H36 QVQLQESGPSQVTPSQTLSLTCTASGFEVTM--YAVGWVRQAPGKALEWLGGIG---------AEGEVGYYPPLKSRLSITRDTSKNQILLSLSSVTIEDTGVYYCVRSYQRII------------------------------------------NYSGGSIDYWGPGLLITVS H224 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTS--NAVGWVRQRPGKVPEWLGSIN---------SGGSTYYNPALKSRLSITRDTSKSQVSLSLSSVTAEDTAVYYCARDPNYNG-------------------------------------------NSPANIDYWGPGLLVTVS H123 QVQLQESGPSLVKPSQTLSLTCTVSGFSLTD--SRIYWVRQAPGKALECVGGIY---------PGGHAEYNPALKSRSSITRDTSKSQVSLSLSSVTTEDTAVYYCAKDASTGG---------------------------------------------IGNSDYWGPGLLVTVS H165 QVQLQERGPSLVKPSQTLSLTCTVSGFSLTS--NSVGWVRQAPGKVPEWPSSLS---------TDGYTHSNLALKSRLSITRDTSKSQVSLSLSSVTTDDTAVYYCVRGADFNV------------------------------------------ITSPHRIDYWGPGLLISVS H21 DVKLQESGPSLVKPSQTLSLTCTVSGFSLIS--NAVQWVRQTPGKVPEWLGGIG--------SGGRGTYYNPALKSRLSITRDTSNSQVSLSLSSVTTEDTAVYYCSRQTITWA--------------------------------------------DHFTVDIWGRGLLLTVS H145 PVKLQESGPSLVKPSETLSLTCTVSGFSLTS--YGINWVRQAPGKALEWLGGVK---------FDGDTVSNPALKSRLSITRDTSKSQVSLSLSSVTSEDTAVYYCGKDWDGWP--------------------------------------------FGEEIDYWGPGLLVTVS H41 QVRLQESGPSLVRPSQALSLTCTVSGFSLDD--YGVVWVRQTPGEALEWVGNVY---------SGGTRYYDPDLKSRLTITRDTSRSQVSLSLSSVTTEDTAVYYCARGRRPPA-----------------------------------DEGGYGYAVAQYYIDTWGPGVLLTIS H266 QVRLQGSGPSLVKPSETLSLTCTISGFSLDS--IAVAWVRQAPGKVPEWLGGVS---------KSGKTWLNPALKSRAGVTREASKSQVSLALRSVTVEDAAVYVCARINSDHC-----------------------------------------CPDGIGFIDYWGPGLLISVL H247 QVQLQESGPSLVKPSQTLSLTCAVSGFSLTS--NAVGWVRQAPGEVPEWLGRVG---------SGGDTYYNPALKSRLSITRDTSKSQVSLSLSSVTTEDTAVYYCTRCDRCCS--------------------------------------------YPNGIDYWGPGLLVTVS H333 QVQLQESGPSLVKPSQTLSLTCTVSGFSLSS--YAIGWVRQAPGMVPEWLGYIN---------SGRGTYYNPALKSRLKFTRDTSESHVSLSLSSITPEDTAVYYCTRGAASAF------------------------------------------PYAVDEIDYWGPGLLVTIS H288 QVQLQESGPSLVKPSQTLSLTCTVSGFSVAA--DNVHWIRQAPGEVPEWLVGIW---------SNGVKEYNSALKSRLSITRDTSENQVSLSLTGVTLEDTAVYYCGRYTGFHT-------------------------------------------------DYWGPGLLVTVS H294 QVRLQGSGPSLVKPSQTLSLTCTGSGFLLSN--YGVGWVRQAPGKALEWLGDVN---------EVGTTFYNAALKSRLSFTRDTSKTQVSLSLSSVTAEDSAVYYCTRADYATR-------------------------------------------SYATNIDMWGPGLLISVS H320 QVRLQQSGPSLVKPSQTLSLTCTVSGFSLTS--YAVGWVRQAPGKALEWVGFVY---------QHGSTYINLALKSRLSITRDTSKSLLSLSLSTVTSEDTAVYYCIRSERDNT------------------------------------------IRDGLPINYWGPGLLISVL H37 QVKLQQSGPGLVKPSQTLSFTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTY-------QRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSMTPEDTAVYYCARGTSTL--------------------------------------------------DYWGQGLLISVL H40 EVKLQESGPGLVKPSQTLSVTCAISGDSASSNNVAWHWVRQSPSRGLEWLGRTY-------YTSRWNYDYAVSVKSRIIINADTSKNQFSLQLNSVTPEDTAIYYCARVGVHDN-------------------------------------------ADFWYFDYWGQGLLVTVS H261 QVKLQESGPGLVEPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTY-------YRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARD------------------------------------------------------QGGNWGLLISVL H281 EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTY-------YRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCASSLDYDS----------------------------------------------SGYDYWGQGLLISVL H242 QVQLQESGPGLVKPSQTLSLTCTVSGGSITSGGWSYYWIRQHPGKGLEWIGYIY---------YSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAWGRIYDS----------------------------------------SGYYPSDAFDIWGQGLLVTVS H225 QVQLQESGPGLVKPSETLSLTCTVSGGSISS--YYWSWIRQPPGKGLEWIGYIY---------YSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAARYCARDQRGYY-------------------------------------------GRLDAFDIWGQGLLVTVS H168 QVQLQQSGAEVKKPGESLKISCKGSGYSFTS--YWIGWVRQMPGKGLEWMGIIY--------PGDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTDMYYCAGSVVVIS--------------------------------------------RPDAFDIWGQGLLVTAS H9 QVKLQESGAEVKKPGESLKISCKGSGYSFTR--YWIGWVRQMPGKGLEWMGIIY--------PGDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARLHTHAF-------------------------------------------------DIWGQGLLVTAS H203 QVQLQESGPELVKTGASVKISCKASGYSFTG--YSLHWVKQSHVKGLEWIGYIS--------RYTGATSYNQKFKGKATFTVDTSSSTAYMQFNSLTSEDSAVYYCARGIITVV-------------------------------------------AKDYAMDYWGQGLLVTVS H204 QVQLQESGAEVARPGASVRVSCKASSYIFTN--YWMQWVKQRPGQGLEWIGYIN--------PSSGYAGYTEKFEGKAILTADKSSNAAYIQLINLASEDSAVYYCARYWDGF-------------------------------------------------AYWGQGLLISVL H11 QVKLQESGAELAKPGASLKMSCKASGYTFTA--YWMHWVKQRPGQGLEWIGYID--------PSTGYAEYNQKFKDKATLTADKSSSTAYMQLSSLTSGDSAVYYCARSYYRYD-----------------------------------------------GLDYWGQGLLVTVS H264 QVKLQESGAELAKPGASVKMSCKASGYTFTA--YWMHWVKQRPGQGLEWIGYID--------PSTGYAEYNQKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSYYRYD-----------------------------------------------GLGYWGQGLLVTVS H299 QVKLQQSGAELVRPGVSVKISCKGSGYTFTD--YAMHWVKQSHAKSLEWIGVIS--------TYYGDASYNQKFKDKATMTVDKSSSTAFLELARLTSEDSDIYYCAREGGNSY------------------------------------------------LDYWGQGLLITAS H12 EVKLQQSGAEVKKPGASVKVSCKASGYTFTS--YYMHWVRQAPGQGLEWMGIIN--------PSGGSTNYAQKFQGRVTTTPDKSTSTAYMELSSLRSEDTAVYYCARVSPDYG-------------------------------------------DYQTPLDYWGQGLLVTVS H217 EVKLQDSGAEVKKPGSSVKVSCKASGGTFSS--YAISWVRQAPGQGLEWMGGII--------PIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAELMVYDG------------------------------------------------HDYWGQGLLITVS H297 QVQLKESGAEVKKPGSSVRVSCKASGGTFSS--YAISWVRQAPGQGLEWMGGII--------PIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARIAPAGT--------------------------------------------LDDAFDIWGQGLLITVS H7 QVQLQQSGRGVVQPGGSLRLSCAASGFTFSS--YWMHWVRQAPGKGLAWVCSIE--------TDGSVTRFADSVKGRFTISTDNAKNTVYLQMNSLRAEDTAVYYCARDLWGEN---------------------------------------------YRNFDYWGQGLLITVS H94 QVQLQESGGGLVQPGGSLRLSCAASGFTFSS--YAMSWVRQAPGKGLEWVCAIS--------GSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDYKSHM------------------------------------------GRGVTPFDYWGQGLLVSAS H257 QVKLQESGGGVVQPGRSLRLSCAASGFTFSS--YGMHWVRQAPGKGLEWVAVIW--------YDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGGEAGG----------------------------------IAVAGTPRVDYYYGMDVWGQGLLITVS H310 QVKLQESGGGVVQPGRSLRLSCAASGFTFSS--YAMHWVRQAPGKGLEWVAVIS--------HDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDEYSGS----------------------------------------------YFSDYWGQGLLVTVS H17 QVQLQQSGPGLAKPSQSLSLTCSVTGYSITS-GYYWNWIRQFPGNKLEWMGYIS---------YDGSNNYNPSLKNRISITRDTPKNQFFLRLNSVTTEDTATYYCAINWDRYW-----------------------------------------------YFDVWGQGLLVTVS H23 QVRLQGSGPGLVAPSQSLSITCTVSGFSLTN--YNLQWVRQPPGKGLEWLGIIW---------PGGTTNYNSALMSRLTITKDNSKSQVFLKTNSLRSYDTAMYYCASYHYGV--------------------------------------------------AYWGQGLLISVL
Pig (Sus scrofa)
Note: Click on the Genback Accession number (Acc. No.) to retrieve the Genbank record Ig-fold B B B T B B B B 111111111 B BIBI T I IBB 22222222222222 TT B B B B T T B BIBI B 333333333333333333333333333333333333333333333333333333333 Position 1 10 20 30 40 50 60 70 80 90 100 110 Genbank Name |...|....|....|....|....|....|.ab...|....|....|....|..abcdefghi..|....|....|....|....|....|..abc..|....|....|....|###################################abcdefghijklmno....|....|.. Acc. No. NP_998993 EEKLVESGGGLVQPGGSLKLSCVASGFIFSK--YIVNWVRLVPGKGLEWLASIW---------STGSTHYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTALYYCAREVCFRY--------------------------------------NTGCWDGYYGMDLWGPGVEVVVS I47210 EEKLVESGGGLVQPGGSLRLSCVGSGFSFSS--YAVSWVGQAPGKGLEWLSSIS--------TSGGSTVYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCARGLATVP-------------------------------------GKPTHVQYYDGLDLWGPGVEVVVS I47209 EEKLVESGGGLVQPGGSLRLSCVGSGFTFST--YGMSWVRQAPGKGLEWLAGIG---------FSGSTYYAVSVKGRFTISRDDSLNTAYLQMNSLRTEDTARYFCVGCYIGCE-------------------------------------------HGWLHEVHLGPGVEVVVS I47208 EEKLVESGGGLVQPGGSLRLSCVGSGLSFSY---GMSWVRQAPGKELEWLASIV--------GSGRSTFYADSVKGRFTISSDSSRNTGYLQMNSLRTEDTARYYCATGHIYGF--------------------------------------------YFWYIDLWGPGVEVVVS I47207 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSV--NAFSWVRQDPGKGLEWLAGIY--------GGGKRTEYADSVKGSLTVSRDNSQNTAYLQMNSLRTEDTARYYCARGFSWNR----------------------------------------------SYIHLWGPGVEVVVS I47206 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSV--IFINWVRQAPGKGLEWLGAIG------SGCYKGFTHYADSVKGRFTISRDSSQDTAYLQMNSLRTEDTARYYCARGYNGVS---------------------------------------------GFVLDFWGPGVEVVVS I47205 EENLVESGGGLVQPGGSLRLSCVGSGFTFRT--YDMIWVREAPGKGLEWLAYIS-------STSGDYTSYAESVKGRFTISRANSQNTAYLQMTSLRTEDTARYYCARDGGAWS------------------------------------------------MDMWGPGIEVVVS I47204 EAKLVESGGGLAQPGGSLRLSCVGSGFTFSS--YNMIWVRQAPGKGLEWLAAIS--------GSGSSTYYADSVKGRFTISRDNSQNTAYLQMFSLRTEESARYYCAHCYDYGA---------------------------------------------GCYMELWGPGVEVVVS I47203 EEKLVESGGGLVQPGGSLRLSCVGSGFNFGS--RPINWVRQAPGKGLEWVAAIS--------TSGGSTYYADSVKGRFTVSRDDSQNTAYLQMNSLRTEDTAHYYCARDGWFGC----------------------------------------GGAYPSIHIDLWGPGVAVVVS I47202 EEKLVESGGGLVQPGGSLRLSCVGSEFTVNS--YPVAWVRQAPGKGLEWLAAIY--------SSGGATYYADSVKGRFTISKDNSQDTAYLQMNTLRTEDTARYYCARIYRECW------------------------------------------GGRCFGMDLWGPGVEVVVS I47201 EVILVESGGGLVQPGGSLRLSCVGSGFDFSI--YSMSWVGQAPGKGPEWLAGIF---------AGGATYYAETVKGGLTISRDSAQSTAYLQMNGLRMKDTARYHCARFAYTSG-----------------------------------------SSLLSDGMDLWGPGVEVVVS I47200 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TDINWVRQAPGKGLEWLAGSD------NGSPSGKTYYLDSVKGRFTISRDDSQNTAYLQMNSLRVEDTALYYCARGRGIAK-------------------------------------NAILIPKSYYTVDLWGPGVEVVVS I47199 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSR--YEINWVRQAPGKGLEWLAGRY-------STSGDRTYYADSAQGRFTISRDDSQNTAYLQMTSLRTDGTARYYCARGSIKAV-------------------------------AIAVDPKSRSPLPSNYAMDLWGPGGEVVVS I47198 QEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YTVNWVRKAPGKGLEWLATTT--------KTGSSAEYADSVKGRFTISRDNFQNTAYLQMKSLRVQDTARYYCANSYNNGV-------------------------------------------NWYYSMDLWGPGVEVVVS I47197 EEKLVESGGGLVEPGGSLRLSCVGSGFNFMV--YEVNWVRQAPGKGLEWLAGIY--------SSGSRTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCTRDYSSQY--------------------------------------------NYYDMYLWGPGVEVVVS I47196 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YAVSWVRQAPGKGLEWLAGIY--------SSGSNTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARFYCARGVSCYT---------------------------------------FGVYCFYYVLDLWGPGVEVVVS I47195 EEKLVESGGGLVQPGGSLRLSCVGSGYTFSN--YAVSWVRQAPGKGLEWLAEVW--------NSGGPINYADSVKGRFTISRDNSQNTAYLQMDRLRTEDTARYYCTRGRG----------------------------------------------------DLWGPGVEVIVS I47194 EEKLVESGGGLVQPGGSLRLSCVGSEYRFSV--YGMSWVRQAPGKGLEWLACIG------GDNWRGRAYYADSVKGRFTISSDKSQNTAYLQLNSLRSEDTARYYCARTYNDCE---------------------------------------------GFGVSLWGPGVEVVVS I47193 EENLVESGGGLVQPGGSLRLSCVGSGFIFNI--NEISWVRQAPGKGLEWLAGIS--------TSGGGTYYADSVKGRFTISRDDSQNTAYLQMNSLRTEDTARYYCGRGYGTTY------------------------------------------------CHLWGPGVEVVVS I47192 EEKLVESGGGLVQPGGSLRLSCVGSGFFFSS--YSMNWVRQSPGKGLEWLACIY--------TRTISDDYADSVKGRITISRDNSQNTAYLQMNSLRTEDTARYYCATGLEGYG--------------------------------------ASCSSTLYFGMELWGPGVEVVVS I47191 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSN--IYIDWVRQASGKGLEWLAGIS--------DSGRRTDYADSVKGRFTVSRDDSQNTAYLQMNSLTTEDTARYYCARSM-----------------------------------------------------HLWGPFVEVVVS I47190 EEKLVESGGGLVQPGGSLRLSCVGSGFIFSS--TWIYWVRQAPGKGLEWLAGIS--SSGFSTGFTIRTFYVESVKGRFTISRDNSQNTAYLQMTSLRTEDKARYFCVNSFGGAM-------------------------------------------------HLWGPGVEVVVS I47188 EVNLVESGGGLVQPGGSLRLSCVGSGFDLSS--YGVIWVRQAPGKGLECLASIG------SSSYSGHTYYADSVKGRFTISSDDSQNTAYLEMYSLRTEDTARYFCARGSLIDG-----------------------------------GLVVVADRPYYYSMDLWGPGVEVVVS I47187 EENLVESGGGLVQPGGSLRLSCVGSGFSFSS--NVINWVRQAPGKGLEWLASSI--------TYGSVTDIAESVKGRFTISRDNSQNTAYLQMNILKTEDTARYYCAKFAYSGC-----------------------------------------DRDWYSSKNIWGPGVEVVVS I47186 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS--------TSGGSTYYTDSMKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCARGRNRYS----------------------------------------NRYSRGGAMDLWGPGVEVVVS I47185 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YAVSWVRQAPGKGLEWLAGID------SGSYTGSTYYADSVKGRFTISRDDSQNTVYLQMNSLRTEDTARYYCAIGPSYGA------------------------------------------SLGPYAMDLWGPGVEVVVS I47184 EVKLVESGGGLVQSGGSLRLSCVGSGFTFSS--YEISWVRQAPGKGLEWLADIC---------SGGSTYYADSVKGRFTISKDNSQNTAYLQMNSLRTEDTARYYCARVKIYSY--------------------------------------GASCYDGIYAMDLWGPGVEVVVS I47183 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS---------TSGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCAGWFIAVA-------------------------------------IAVTRIPPYYAMDLWGPGVEVVVS I47182 EENLVESGGGLVQPGGSLRLSCVGSGFTSSS--YGMNWVRQAPGKGLEWLACIY--------SSGSRTYYADSVKGRCTISRDNSQNTAYLQMDSLRTEDTAHYYCVTGDASWC--------------------------------------------PFRKVHLWGPGVEVVVS I47181 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSN--TDIIWVRQAPGKGLEWLARIW--------SSGTDTYYSDSVKGRFTISKDKSQNAAYLQMNSLITEDTAHYYCATGSGYVD------------------------------------------------FHLWGPGVEVVVS I47180 EVKLVESGGGLVQPGGSLRLSCVGSGFTFSN--TDISWVRQAPGKGLEWLGMVY---------SSGNTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCARGPDCYS------------------------------------YGATCYRSGLDAMDLWGPGVEVVVS I47179 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YKVSWVRQAPGKGLEWLAEIY--------SSGSDTYYADSVKGRFTISRDNSQNTAYHQMNSLRTEDTARYYCASPGLLDC--------------------------------------------YGFCENIWGPGVELVVS I47178 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSD--YGIYWVRQAPGKGLEWLAGIA--------SSGNFIDYADSVRGRFTISRDNSQNTAYLQINSLTTEDTARYYCAKGLVLRS--------------------------------------------YHSSIHLWGPGVEVVVS CAH69216 EEKLVESGGGLVQPGGSLKLSCVGSGFTFSS--YNMIWVRQAPGKGLEWLAYIT--------SSGGSTYYADSVKGRFTISSDNSQNTAYLQMNSLRTEDTARYYCARGLLQVT----------------------------------------------YAMDLWGPGVEVVVS CAH68519 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS--------TSGGSTYYTDSVEGRFTISKDNSQNTAYLQMNSLRTEDTARYYCATGLCNRY---------------------------------------GITCPHYDAMDLWGPGVEVVVS CAH68518 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YEISWVRQAPGKGLEWLAGIY--------SSGSSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCARGLYSGS---------------------------------------WGWIRRRRNMDLWGPGVEVVVS CAH68517 EEKLVESGGGLVQPGGSLRLSCVDSGFDFSD--NAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADTVKGRFTISSDDSQNTVYLQMNSLRTEDTARYYCAIAVAIAV--------------------------------------------TWGPMDLWGPGVEVVVS CAH68516 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--NAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDDSQNTVYLQMNSLRTEDTARYYCARAYIMVL----------------------------------------------VFMDLWGPGVEVVVS CAH68513 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--NAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDNSQNTVYLQMNSLRTEDTARYYCAIGVAMVL-----------------------------------------VAMTPGVMDLWGPGVEVVVS CAH68509 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLTAIS--------TSGGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCAREDYSGC----------------------------------------YSGYCVRHMDLWGPGVEVVVS CAH68508 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS--------TSGGSTYYADSVKGRFTISRDNSQNTAYLQMNSLGTEDTARYYCATGWLAIA-------------------------------------------MVLVAMDLWGPGVEVVVS CAH68507 EEKLVESGGGLVQPGGSLRLSCVGSGYTFSS--YGMSWVRQAPGKGLEWLAGID------SGSYSGSSYYADSVKGRFTISRDDSQNTAYLQMNSLRTEDTARYYCATGGCYSG-----------------------------------------YCPIGWIMDLWGPGVEVVVS CAH68506 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--YAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDDSQNMVYLQMNSLRTEDTARYYCAISGCYSG-----------------------------------------YGGCDYAMDLWGPGVEVVVS CAH68505 EEKLVESGGGLVQPGGSLRLSCVGSGITFSS--YALSWVRQAPGKGLEWLAGID------SGSYTGSTYYADSVKGRFTISRDDSQNTAYLQMNSLRTEDTARYYCAGYYQTIA----------------------------------------------VAIAGRGPGVEVVVS CAH68504 EEKLVESGGGLVQPGGSLRLSCVGSGITFSS--YAVSWVRQAPGKGLESLAGID------SGSYSGSTYYADSVKGRFTISRDDSQNTAYLQMTSLRTEDTARYYCAGGNCYGA-------------------------------------------SCYYAMDLWGPGVEVVVS CAH68497 EEKLVESGGGLVQPGGSLRLSCVGSGITFSS--YAVSWVRQAPGKGLEWLAGID------SGSYSGSTYYADSVKGRFTISRDDSQNTAYLQMTSLRTEDTARYYCAGCLYGAS---------------------------------------CYEGGNYYAMDLWGPGVEVVVS CAH68488 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSS--YGVGWVRQAPGKGLESLASIG------SGSYIGSTYYADSVKGRFTISSDDSQNTVYLQMNSLRTEDTARYYCARCCYSYG-----------------------------------------ASFPGYAMDLWGPGVEVVVS CAH68480 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--YAFSWVCQAPGKGLEWLAAIS--------TSGGSTYYADSVKGRFTISKDNSQNTAYLQMNSLRTEDTARYYCARGRRLPY----------------------------------------------YAMDLWGPGVEVVVS CAH68477 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--YAFSWVRQAPGKGLEWLAGID------SGSYSGSTYYADSVKGRFTISRDDSQNTAYLQMTSLRTEDTARYYCAGGNCYGA-------------------------------------------SCYYAMDLWGPGVEVVVS CAH68474 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS--------TSGGNTYYADSVKGRFTISRDDSQNTAYLQMTSLRTEDTARYYCAGCRVAMV--------------------------------------------LVATMDLWGPGVEVVVS CAH68472 EEKLVESGGGLVQPGGSMRLSCVGSGFDFSD--NAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDDSQNTVYLQMNSLRTEDTARYYCAIAYCYSY------------------------------------------GASCLGGPLWGPGVEVVVS CAH68469 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YEISWVRQAPGKGLEWLAAIG------CGSYSGSTYYADSVKGRFTISSDNSQNTAYLQMNSLRTEDTARYYCARVRIAIA-------------------------------------MVLVTIPFAPAMDLWGPGVEVVVS CAH68467 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--NAFSWVRQAPGKGLEWVAAIS--------TSGGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCASPKIAVA-------------------------------------------IAVTLMDLWGPGVEVVVS CAH68460 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YEISWVRQAPGKGLEWLAGIY--------SSGSSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTAHYYCARGISYGA--------------------------------------SYYDDSDYYAMDLWGPGVEVVVS CAH68459 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YEISWVRQAPGKGLEWLAAIG------CGSYSGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCAPYSYGAS-------------------------------------------YYDDDMDLWGPGVEVVVS CAH68458 EEKLVESGGGPVQPGGSLRLSCVGSGFDFSD--YAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDDSQNMVYLQMNSLRTEDTARYYCAIAVAIAV--------------------------------------------TLGAMDLWGPGVEVVVS CAH68457 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--YAFIWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDDSQNMVYLQMNSLRTEDTARYYCAIAVAIAV--------------------------------------------TLGAMDLWGPGVEVVVS CAH68455 EEKLVESGGGLVQPGGSRRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS--------ASGGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRAEDTARYYCAAWEAGTI------------------------------------------AVYGYAMDLWGPGVEVVVS CAH68453 EEKLVECGGGLVQPGGSLRLSCVGSGITFSS--YAMSWVRPAPGKGLESLVGID------SGSYSGSTYYADSVKGRFTISRDDSQNTAYLQMTSLRTEDTARYYCAGGNCYGA-------------------------------------------SCYYAMDLWGPGVEVVVS CAH68452 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TNINWVRQAPGKGLEWLAVIS--------TSGGSTYYADSVKGRFTISSDNSQNTAYLQMNSLRTEDTARYYCATRLSGCY---------------------------------------------SGYLPLWGPGVEVVVS AAX07329 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YSMSWVRQAPGKGLEWLACIY--------SSGSSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCAK AAX07328 EEKLVESGGGLVQPGWSLRLSCVGSGYTFSS--YGIGWVRQAPGKGLEWLAGIY---------SGGSTYYADSVKGRFTISKDNSQNTAYLQMNSLRTEDTARYYCAR AAX07326 EVKLVESGGGLVQPGGSLRLSCVGSVFDFSS--YAVSWVRQAPGKGLEWLAAIY---------SGGSSYYADSVKGRFTISKDNSQNTAYLQMNSLRTEDTARYYCAT AAX07325 QEKLVESGGGLVQPGGSLRLSCVGSGFDFSS--YSMSWVRQAPGKGLEWVAGIY--------SSGSSTYYADSVKGRFTISSDDSQNTVYLQMNSLRTEDTARYYCAI CAH69217 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YNMIWVRQAPGKGLEWLAAIG------CGSYSGSTYYADSVKGRFTISSDNSQNTAYLQMNSLRTEDTARYYCAT CAH69215 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--TYINWVRQAPGKGLEWLAAIS--------TSGGSTYYADSVKGRFTISRDDSQNTAYLQMNSLRTEDTARYYCAR CAH68501 EEKLVESGGGLVQPVGSLRLSCVGSGFTFSS--YSMSWVRQAPGKGLEWLACIY--------SSGSSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTDDTARYYCAT CAH68496 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YEISWDRQAPGKGLEWLAAIS--------TSGGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCAT CAH68495 EEKLVESGGGLVQPGGSLRLSCVGSGFDFSD--NAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADFVKGRFTISSDNSQNTVYLQMNSLRTEDTARYYCAT CAH68491 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YSMSWVRQAPGKGLEWLACIY--------SSGSSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEGTARYYCAT CAH68485 EEKLVESGGGLVQTGGSLRLSCVGSGFDFSS--YGVGWVRQAPGKGLESLASIG------SGSYIGSTYYADSVKGRFTISRDNSQNTAYLQMNSLRTEDTARYYCAR CAH68462 EEKLVESGGGLVQPGGSLRLSCVGSGFAFSD--NAFSWVRQAPGKGLEWVAAIA------SSDYDGSTYYADSVKGRFTISSDNSQNTMYLQMNSLRTEDTARYYCAI CAH68454 EEKLVESGGGLVQPGGSLRLSCVGSGFTFSS--YAVSWVRQAPGKGLEWLAGIY--------SSGSSTYYADSVKGRFTISRDNSQNTAYLQMNSRRTEDMARYYCAT