Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Sabino Pacheco Guillen


Dr. Sabino Pacheco Guillen


Grupo del Dr. Mario Soberón



Oficina +52 (777) 311-4900 ext 227

Laboratorio +52 (777) 329-1624
desde la CDMX 562-27624

red UNAM 27624
+52 (777) 311-4900 ext 227


M.C. Maria Luisa Zardo

Emanuel Christian Macario

Lic. Vianca Alicia López

I.B.Q. Aurora Massiel Diaz

Lic. Carlos Espindola "Selección de inhibidores de la interacción derivados de Cren7 de un sistema toxina-antitoxina de Salmonella entrica."

Ing. Diego Peinado

Jean Piere Jesús Quiliche

Publicaciones recientes

Wang,Z. Fang,L. Zhou,Z. Pacheco,S. Gomez,I. Song,F. Soberon,M. Zhang,J. Bravo,A. 2018. Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis) Journal of Biological Chemistry, Jun 1 [Epub ahead of print], .

Torres-Quintero,M.C. Gomez,I. Pacheco,S. Sanchez,J. Flores,H. Osuna,J. Mendoza,G. Soberon,M. Bravo,A. 2018. Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity Scientific Reports, 8, 4989.

Soberon,M. Portugal,L. Garcia-Gomez,B.I. Sanchez,J. Onofre,J. Gomez,I. Pacheco,S. Bravo,A. 2018. Cell lines as models for the study of Cry toxins from Bacillus thuringiensis Insect Biochemistry and Molecular Biology, 93, 66-78.

Pacheco,S. Gomez,I. Sanchez,J. Garcia-Gomez,B.I. Soberon,M. Bravo,A. 2017. Intra-molecular salt bridge in Bacillus thuringiensis Cry4Ba toxin is involved in the stability of helix alpha-3 that is needed for oligomerization and insecticidal activity Applied and Environmental Microbiology, 83, e01515-e01517.

Ares,M.A. Rios-Sarabia,N. De la Cruz,M.A. Rivera-Gutierrez,S. Garcia-Morales,L. Leon-Solis,L. Espitia,C. Pacheco,S. Cerna-Cortes,J.F. Helguera-Repetto,C.A. Garcia,M.J. Gonzalez Y Merchand J.A. 2017. The sigma factor SigD of Mycobacterium tuberculosis putatively enhances gene expression of the septum site determining protein under stressful environments New Microbiologica, 40, .

Ares,M.A. Fernandez-Vazquez,J.L. Pacheco,S. Martinez-Santos,V.I. Jarillo-Quijada,M.D. Torres,J. Alcantar-Curiel,M.D. Gonzalez Y Merchand J.A. De la Cruz,M.A. 2017. Additional regulatory activities of MrkH for the transcriptional expression of the Klebsiella pneumoniae mrk genes: Antagonist of H-NS and repressor PLoS ONE, 12, e0173285.

Onofre,J. Gaytan,M.O. Pena-Cardena,A. Garcia-Gomez,B.I. Pacheco,S. Gomez,I. Bravo,A. Soberon,M. 2017. Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta Peptides, 98, 93-98.

Xiao,Y. Dai,Q. Hu,R. Pacheco,S. Yang,Y. Liang,G. Soberon,M. Bravo,A. Liu,K. Wu,K. 2017. A Single Point Mutation Resulting in Cadherin Mis-localization Underpins Resistance against Bacillus thuringiensis Toxin in Cotton Bollworm Journal of Biological Chemistry, 292, 2933-2943.

De la Cruz,M.A. Ruiz-Tagle,A. Ares,M.A. Pacheco,S. Yanez,J.A. Cedillo,L. Torres,J. Giron,J.A. 2017. The Expression of Longus type 4 pilus of enterotoxigenic Escherichia coli is regulated by LngR and LngS, and by H-NS, CpxR, and CRP global regulators Environmental Microbiology, 19, 1761-1775.

Cardenas-Mondragon,M.G. Ares,M.A. Panunzi,L.G. Pacheco,S. Camorlinga-Ponce,M. Giron,J.A. Torres,J. De la Cruz,M.A. 2016. Transcriptional Profiling of Type II Toxin-Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967-HP0968 System Frontiers in Microbiology, 7, 1872.

Pacheco,S. Canton,E. Zuniga-Navarrete,F. Pecorari,F. Bravo,A. Soberon,M. 2015. Improvement and efficient display of Bacillus thuringiensis toxins on M13 phages and ribosomes AMB Express, 5, 73.

Behar,G. Pacheco,S. Maillasson,M. Mouratou,B. Pecorari,F. 2014. Switching an anti-IgG binding site between archaeal extremophilic proteins results in Affitins with enhanced pH stability Journal of Biotechnology, 192PA, 123-129 * .

Pacheco,S. Behar,G. Maillasson,M. Mouratou,B. Pecorari,F. 2014. Affinity transfer to the archaeal extremophilic Sac7d protein by insertion of a CDR Protein Engineering Design & Selection, 27, 431-438 * .

Correa,A. Pacheco,S. Mechaly,A.E. Obal,G. Behar,G. Mouratou,B. Oppezzo,P. Alzari,P.M. Pecorari,F. 2014. Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins) PLoS ONE, 9, e97438 * .

Libros y capítulos recientes

Bravo,A. Pacheco,S. Gomez,I. Garcia-Gomez,B. Onofre,J. Soberon,M. 2017. Insecticidal Proteins from Bacillus thuringiensis and Their Mechanism of Action en: Crickmore,N. Bacillus thuringiensis and Lysinibacillus sphaericus: Characterization and use in the field of biocontrol. Cham. Springer International Publishing. pags. 53-66

Soberon,M. Garcia-Gomez,B.I. Pacheco,S. Sanchez-Quintana J Tabashnik,B.E. Bravo,A. 2015. Countering pest resistance with genetically modified Bt toxins en: Bravo,A. Bt resistance-characterization and strategies for GM crops expressing Bacillus thuringiensis. Oxford. CABI. pags. 150-161

Bravo,A. Martinez-de-Castro,D.L. Sanchez-Quintana J Canton,P.E. Mendoza,G. Gomez,I. Pacheco,S. Garcia-Gomez,B.I. Onofre,J. Ocelotl,J. Soberon,M. 2015. Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests en: Alouf,J.E. Comprehensive Sourcebook of Bacterial Protein Toxins 4a ed. Elsevier. pags. 858-873

* Indica publicación con otra institución de adscripción

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