Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Lourival Domingos Possani Postay

Dr.

Dr. Lourival Domingos Possani Postay


Líder Académico »» Grupo

Investigador

Tutor de Maestría y Doctorado

Nivel Inv. de Excelencia del SNI

Departamento de Medicina Molecular y Bioprocesos

Líneas de investigación

email: possani@ibt.unam.mx


- Licenciatura: Historia Natural, Fac. de Filosofía de la Universidad Federal de Río Grande do Sul, Brasil (1966)
- Doctorado: en Biofísica, Faculte des Sciences D'Orsay-Universite de París, Francia (octubre 1968-marzo 1970)
- Mencion honorífica en examen de Doctorado (1970)
- Estancia de investigacion en la Universidad Rockefeller, New York, E.U.A. (julio 1971-septiembre 1973)


Premio Redi International Society on Toxinology (2006)
Investigador emérito UNAM (2005)
Doctor Honoris Causa Universidad de Debrecen, Hungría (2005)
Miembro de la Academia de Ciencias de America Latina (1999)
Premio Nacional de Investigación Básica Fundación Glaxo-Wellcome (1998)
Howard Hughes Medical Institute International Research Scholar 1997-2001 (1997)
Premio Nacional de Ciencias y Artes Gobierno de la República (1995)
Premio de Investigacion Medica Dr. Jorge Rosenkran (1994)
Premio Universidad Nacional en el área de Ciencias Naturales UNAM (1993)
Howard Hughes Medical Institute International Research Scholar 1991-1996 (1991)


Estudiantes

M.C. Jimena Isaias Cid

Ing. Rosby del Carmen Najera "Caracterización bioquimica de dos toxinas con posible actividad insecticida"

Lic. Volkan Ulutas

M.C Maria Teresa Romero

M.C. Jose Ignacio Veytia

Publicaciones recientes

Restano-Cassulini,R. Garcia,W. Paniagua-Solis,J.F. Possani,L.D. 2017. Antivenom Evaluation by Electrophysiological Analysis Toxins (Basel), 9, .

Vargas-Jaimes,L. Xiao,L. Zhang,J. Possani,L.D. Valdivia,H.H. Quintero-Hernandez,V. 2017. Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors Biochimica et Biophysica Acta (BBA), 1861, 936-946.

Jimenez-Vargas,J.M. Quintero-Hernandez,V. Gonzalez-Morales,L. Ortiz,E. Possani,L.D. 2017. Design and expression of recombinant toxins from Mexican scorpions of the genus Centruroides for production of antivenoms Toxicon, 128, 5-14 [Corrigendum 130 (2017) 126].

Jauregui-Zuniga,D. Pedraza-Escalona,M. Espino-Solis,G.P. Quintero-Hernandez,V. Olvera-Rodriguez,A. Diaz-Salinas,M.A. Lopez,S. Possani,L.D. 2017. Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example Research in Veterinary Science, 111, 55-62.

Cid Uribe,J.I. Jimenez Vargas,J.M. Ferreira Batista,C.V. Zamudio-Zuniga F. Possani,L.D. 2017. Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found Toxicon, 125, 91-98.

Olamendi-Portugal,T. Restano-Cassulini,R. Riano-Umbarila,L. Becerril,B. Possani,L.D. 2017. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus Peptides, 87, 34-40.

Santibanez-Lopez,C.E. Cid-Uribe,J.I. Batista,C.V. Ortiz,E. Possani,L.D. 2016. Venom Gland Transcriptomic and Proteomic Analyses of the Enigmatic Scorpion Superstitionia donensis (Scorpiones: Superstitioniidae), with Insights on the Evolution of Its Venom Components Toxins (Basel), 8, .

Osnaya-Romero N. Acosta-Saavedra,L.C. Goytia-Acevedo,R. Lares-Asseff,I. Basurto-Celaya,G. Perez-Guille,G. Possani,L.D. Calderon-Aranda,E.S. 2016. Serum level of scorpion toxins, electrolytes and electrocardiogram alterations in Mexican children envenomed by scorpion sting Toxicon, 122, 103-108.

Luna-Martinez,K. Jimenez-Vargas,J.M. Possani,L.D. 2016. Scorpine-Like Peptides Single Cell Biology, 5, .

Rodriguez-Rodriguez,E.R. Olamendi-Portugal,T. Serrano-Posada,H. Arredondo-Lopez,J.N. Gomez-Ramirez,I. Fernandez-Taboada,G. Possani,L.D. Vega,G.A. Riano-Umbarila,L. Becerril,B. 2016. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions Toxicon, 119, 52-63.

Zhang,H. Du,M. Xie,J. Liu,X. Sun,J. Wang,W. Xin,X. Possani,L.D. Yea,K. Lerner,R.A. 2016. Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries Angewandte Chemie International Edition, 55, 9306-9310.

Valdez-Velazquez,L.L. Romero-Gutierrez,M.T. Delgado-Enciso,I. Dobrovinskaya,O. Melnikov,V. Quintero-Hernandez,V. Ceballos-Magana,S.G. Gaitan-Hinojosa,M.A. Coronas,F.I. Puebla-Perez,A.M. Zamudio,F. De la Cruz-Garcia,I. Vazquez-Vuelvas,O.F. Soriano-Hernandez,A.D. Possani,L.D. 2016. Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities Toxicon, 118, 95-103.

Xiao,L. Gurrola,G.B. Zhang,J. Valdivia,C.R. SanMartin,M. Zamudio,F.Z. Zhang,L. Possani,L.D. Valdivia,H.H. 2016. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands Journal of General Physiology, 147, 375-394.

Olamendi-Portugal,T. Bartok,A. Zamudio-Zuniga,F. Balajthy,A. Becerril,B. Panyi,G. Possani,L.D. 2016. Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus Toxicon, 115, 1-12.

Figueroa-Montiel,A. Ramos,M.A. Mares,R.E. Duenas,S. Pimienta,G. Ortiz,E. Possani,L.D. Licea-Navarro,A.F. 2016. In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus PLoS ONE, 11, e0148390.

Santibanez-Lopez,C.E. Francke,O.F. Ureta,C. Possani,L.D. 2016. Scorpions from Mexico: From Species Diversity to Venom Complexity Toxins (Basel), 8, 2.

Riano-Umbarila,L. Ledezma-Candanoza,L.M. Serrano-Posada,H. Fernandez-Taboada,G. Olamendi-Portugal,T. Rojas-Trejo,S. Gomez-Ramirez,I.V. Rudino-Pinera,E. Possani,L.D. Becerril,B. 2016. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin Journal of Biological Chemistry, 291, 1619-1630.

Ramirez-Carreto,S. Jimenez-Vargas,J.M. Rivas-Santiago,B. Corzo,G. Possani,L.D. Becerril,B. Ortiz,E. 2015. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity Peptides, 73, 51-59.

Santibanez-Lopez,C.E. Possani,L.D. 2015. Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution Toxicon, 107, 317-326.

Rodriguez-Ravelo,R. Batista,C.V. Coronas,F.I. Zamudio,F.Z. Hernandez-Orihuela,L. Espinosa-Lopez,G. Ruiz-Urquiola,A. Possani,L.D. 2015. Comparative proteomic analysis of male and female venoms from the Cuban scorpion Rhopalurus junceus Toxicon, 107, 327-334.

Ortiz,E. Possani,L.D. 2015. The unfulfilled promises of scorpion insectotoxins Journal of Venomous Animals and Toxins Including Tropical Diseases, 21, .

Luna-Ramirez,K. Quintero-Hernandez,V. Juarez-Gonzalez,V.R. Possani,L.D. 2015. Whole Transcriptome of the Venom Gland from Urodacus yaschenkoi Scorpion PLoS ONE, 10, e0127883.

Espino-Solis,G.P. Quintero-Hernandez,V. Olvera-Rodriguez,A. Calderon-Amador,J. Pedraza-Escalona,M. Licea-Navarro,A. Flores-Romo,L. Possani,L.D. 2015. Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin Veterinary Immunology and Immunopathology, 164, 220-226.

Quintero-Hernandez,V. Ramirez-Carreto,S. Romero-Gutierrez,M.T. Valdez-Velazquez,L.L. Becerril,B. Possani,L.D. Ortiz,E. 2015. Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus PLoS ONE, 10, e0117188.

Okada,M. Corzo,G. Romero-Perez,G.A. Coronas,F. Matsuda,H. Possani,L.D. 2015. A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain Biochimica et Biophysica Acta (BBA), 1850, 657-666.

Ortiz,E. Gurrola,G.B. Schwartz,E.F. Possani,L.D. 2015. Scorpion venom components as potential candidates for drug development Toxicon, 93, 125-135.

Coronas,F.I. Diego-Garcia,E. Restano-Cassulini,R. de Roodt,A.R. Possani,L.D. 2015. Biochemical and physiological characterization of a new Na-channel specific peptide from the venom of the Argentinean scorpion Tityus trivittatus Peptides, 68, 11-16.

Picco,C. Corzo,G. Possani,L.D. Prestipino,G. 2014. Interaction of the scorpion toxin Discrepin with Kv4.3 channels and A-type K channels in cerebellum granular cells Biochimica et Biophysica Acta, 1840, 2744-2751.

Pedraza-Escalona,M. Batista,C.V. Restano-Cassulini,R. Sandoval-Rios,M. Coronas,F.I. Possani,L.D. 2014. A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells Journal of Proteomics, 111, 212-223.

Gonzalez-Morales,L. Pedraza-Escalona,M. Diego-Garcia,E. Restano-Cassulini,R. Batista,C.V. Gutierrez,M.C. Possani,L.D. 2014. Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis Journal of Proteomics, 111, 224-237.

Luna-Ramirez,K. Bartok,A. Restano-Cassulini,R. Quintero-Hernandez,V. Coronas,F. Christensen,J. Wright,C.E. Panyi,G. Possani,L.D. 2014. Structure, Molecular Modeling and Function of the First Potassium Channel Blocker, Urotoxin, Isolated from the Venom of the Australian Scorpion Urodacus Yaschenkoi Molecular Pharmacology, 86, 28-41.

Vergara,I. Pedraza-Escalona,M. Paniagua,D. Restano-Cassulini,R. Zamudio,F. Batista,C.V. Possani,L.D. Alagon,A. 2014. Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A Journal of Proteomics, 105, 295-306.

Ortiz,E. Rendon-Anaya,M. Rego,S.C. Schwartz,E.F. Possani,L.D. 2014. Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera Biochimica et Biophysica Acta (BBA), 1840, 1738-1746.

Rodriguez-Ravelo,R. Restano-Cassulini,R. Zamudio,F.Z. Coronas,F.I.V. Espinosa-Lopez,G. Possani,L.D. 2014. A K+ channel blocking peptide from the Cuban scorpion Rhopalurus garridoi Peptides, 53, 42-47.

Luna-Ramirez,K. Sani,M.A. Silva-Sanchez,J. Jimenez-Vargas,J.M. Reyna-Flores,F. Winkel,K.D. Wright,C.E. Possani,L.D. Separovic,F. 2014. Membrane Interactions and Biological Activity of Antimicrobial Peptides from Australian Scorpion Biochimica et Biophysica Acta, 1838, 2140-2148.

Riano-Umbarila,L. Olamendi-Portugal,T. Morelos-Juarez,C. Gurrola,G.B. Possani,L.D. Becerril,B. 2013. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins Toxicon, 76, 370-376.

Abdel-Rahman,M.A. Quintero-Hernandez,V. Possani,L.D. 2013. Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae) Toxicon, 74, 193-207.

Quintero-Hernandez,V. Jimenez-Vargas,J.M. Gurrola,G.B. Valdivia,H.H. Possani,L.D. 2013. Scorpion venom components that affect ion-channels function Toxicon, 76, 328-342.

Rodriguez-Ravelo,R. Coronas,F.I. Zamudio,F.Z. Gonzalez-Morales,L. Lopez,G.E. Urquiola,A.R. Possani,L.D. 2013. The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas Journal of Venomous Animals and Toxins Including Tropical Diseases, 19, 13.

Valdez-Velazquez,L.L. Quintero-Hernandez,V. Romero-Gutierrez,M.T. Coronas,F.I.V. Possani,L.D. 2013. Mass Fingerprinting of the Venom and Transcriptome of Venom Gland of Scorpion Centruroides tecomanus PLoS ONE, 8, .

Deuis,J.R. Zimmermann,K. Romanovsky,A.A. Possani,L.D. Cabot,P.J. Lewis,R.J. Vetter,I. 2013. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na1.6 in peripheral pain pathways Pain, 154, 1749-1757.

Schwartz,E.F. Bartok,A. Schwartz,C.A. Papp,F. Gomez-Lagunas,F. Panyi,G. Possani,L.D. 2013. OcyKTx2, a new K-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum Peptides, 46, 40-46.

Bernaldez,J. Roman-Gonzalez,S.A. Martinez,O. Jimenez,S. Vivas,O. Arenas,I. Corzo,G. Arreguin,R. Garcia,D.E. Possani,L.D. Licea,A. 2013. A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity Marine Drugs, 11, 1188-1202.

Mourao,C.B. Heghinian,M.D. Barbosa,E.A. Mari,F. Bloch,C., Jr. Restano-Cassulini,R. Possani,L.D. Schwartz,E.F. 2013. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment into the HWTX-II family Biochemistry, 52, 2440-2452.

Sanchez-Vasquez,L. Silva-Sanchez,J. Jimenez-Vargas,J.M. Rodriguez-Romero,A. Munoz-Garay,C. Rodriguez,M.C. Gurrola,G.B. Possani,L.D. 2013. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin Biochimica et Biophysica Acta (BBA), 1830, 3427-3436.

Caliskan,F. Quintero-Hernandez,V. Restano-Cassulini,R. Coronas-Valderrama,F.I. Corzo,G. Possani,L.D. 2013. Molecular cloning and biochemical characterization of the first Na+-channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom Biochimie, 95, 1216-1222.

Aguilar,M.B. Ortiz,E. Kaas,Q. Lopez-Vera,E. Becerril,B. Possani,L.D. de la Cotera,E.P. 2013. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily Peptides, 41, 17-20.

Pedraza-Escalona,M. Possani,L.D. 2013. Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects Frontiers in Bioscience, 18, 572-587.

Luna-Ramirez,K. Quintero-Hernandez,V. Vargas-Jaimes,L. Batista,C.V. Winkel,K. Possani,L.D. 2013. Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity Toxicon, 63, 44-54.

Garcia,F. Villegas,E. Espino-Solis,G.P. Rodriguez,A. Paniagua-Solis,J.F. Sandoval-Lopez,G. Possani,L.D. Corzo,G. 2013. Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics Journal of Antibiotics, 66, 3-10.

Libros y capítulos recientes

Rodriguez de la Vega,R.C. Corzo,G. Possani,L.D. 2014. Scorpion Venoms as a Platform for Drug Development en: Guccione,S. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. Cambridge. Royal Society of Chemistry. pags. 204-220

Rodriguez-Rodriguez,E.R. Riano-Umbarila,L. Possani,L.D. Becerril,B. 2014. Recombinant neutralizing antibodies, a new generation of scorpion anti-venoms en: Gopalakrishnakone,P. Scorpion Venoms. Springer. pags. 139-159

Abdel-Rahman,M.A. Quintero-Hernandez,V. Possani,L.D. 2014. Scorpion Venom Gland Transcriptomics and Proteomics: An Overview en: Calvete,J.J. Venom Genomics and Proteomics. Springer Netherlands. pags. 1-17

Gopalakrishnakone,P. Possani,L.D. Schwartz,E. Rodriguez-de-la-Vega,R. 2014. Scorpion Venoms Springer.

Rodriguez-de-la-Vega,R. Vidal,N. Possani,L.D. 2013. Scorpion Peptides en: Kastin,A.J. Handbook of Biologically Active Peptides, second edition. Elsevier. pags. 423-429

Petricevich,V.L. Barbosa-Navarro,L. Possani,L.D. 2013. Therapeutic use of scorpion venom en: Ferat-Osorio,E. Molecular aspects of inflammation. Kerala. Research Signpost. pags. 209-231

(error para baltzar)


Divulgación

Becerril-Lujan,B. Riano,L. Possani,L. 2014. Bancos de anticuerpos recombinantes de origen humano: una fuente ideal de antivenenos modernos contra la picadura de alacrán Revista Digital Universitaria, 15, art 84.

Garcia,M.L. Possani,L.D. 2007. Gating modifier peptides of ion channels Toxicon, 49, 123.

Possani,L.D. 2003. The past, present, and future of biotechnology in Mexico Nature Biotechnology, 21, 582-583.

Possani,L.D. 2000. Alacranismo en Mexico.La salud en Durango, 1, 5-6.

Domingos Possani,L. 1983. The toxins of scorpion venom: structure and function.Boletin de estudios medicos y biologicos, 32, 285-297.


Patentes

I. Arenas, R. Rodríguez, Possani, L.D., O. Walls, Corzo, G., 2015 Actividad antimicrobiana "in vitro" de la combinación de péptidos antibiocidas de alacrán con antibióticos de uso común.UNAM Oficina de Patentes Mexico. (en trámite)

Ortiz, E., Ramírez-Carreto, S., Jiménez-Vargas, J.M., Corzo, G., Possani, L.D., 2015 Péptidos del alacrán Vaejovispunctatus como antibióticos contra Mycobacterium tuberculosis y otras bacterias y levaduras patógenas. Oficina de Patentes Mexico. (en trámite)

L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2012 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM México.

Corzo G. , Garcia F. , Possani L.D. , Villegas E. 2011 Uso de un peptido antibiotico proveniente del veneno del alacran Centruroides suffusus suffusus y sus composiciones farmaceuticas obtenidas con antibioticos comerciales.UNAM México. (en trámite)

Corzo, G., Estrada. G. , Hernandez, K. , Garcia B.I. , Possani. L.D 2011 Variantes recombinantes de una toxina del veneno del alacrán Centruroides sufussus sufussus para la producción de antivenenos contra el veneno de alacranes del género Centruroides.UNAM México.

A. Alagón C., L. D. Possani P, G. Gurrola B., E. V. Grishin, A. V. Lipkin & K. E. Volynski 2010 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM Mexico.

L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2009 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Europa 07734817.5,Estados Unidos 12/599,978, China 200780053305.7, Canadá CA 2686216, Australia 2007353147, Israel 202113, Euroasia 200901530, Corea 10-2009-7026000,Brasil (pendiente), Cuba 2009-0194, Japón (pendiente), India 7396/DELNP/2009,u Israel 202113, Corea 10-2009-7026000, y Singapur 200907395-8. (en trámite)

Georgina Gurrola Briones, Cynthia Annabel Hernández Aponte, Jesús Silva Sánchez, y Lourival Domingos Possani Postay 2009 Vejovina - Un péptido antibiótico.UNAM México. (en trámite)

L. Riaño U., B. Becerril L. y L. Possani P 2009 Variantes de anticuerpos humanos que reconocen específicamente a la toxina CN2 y al veneno del alacrán Centruroides noxius.UNAM México.

L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2009 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Sudáfrica.

L. Riaño, B. Becerril y L.D. Possani 2008 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom.UNAM Estados Unidos.

M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L.D. Possani 2008 Recombinant Immunogens for the Generation of Antivenoms to the Venom of Scorpions of the Genus Centruroides.UNAM Estados Unidos.

B. I. García-Gómez, T. C. Olamendi-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género Parabuthus.UNAM México. (en trámite)

G.A.Corzo-Burguete, G. Estrada-Tapia, K. Hernández-Salgado, B. I. García-Gómez y L. D. Possani P 2008 Inmunógenos recombinantes para la producción de antivenenos contra el veneno de alacranes del género Centruroides.UNAM México. (en trámite)

L.D. Possani, F. Zamudio y A. Torres 2007 Hadrurina - Un péptido antibiótico.UNAM México.

L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2007 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM PCT. (en trámite)

B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y M. C. García 2005 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides (Divisional).UNAM México.

Riaño L. , B. Becerril y L.D. Possani 2005 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpionon venom. Estados Unidos. (en trámite)

M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L. D. Possani 2003 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides.UNAM México. (en trámite)

M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L. D. Possani 2002 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides.UNAM Estados Unidos. (en trámite)

B. Becerril, F. Zamudio, B. Selisko, L. D. Possani, A. Ramírez y C. García 2002 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides.UNAM México.

B. Becerril, F. Zamudio, B. Selisko, L.D. Possani, A. Ramírez y M.C. García 2002 Secuencia Primaria y ADNc de toxinas con actividad insecticida de alacranes del género Centruroides (Divisional).UNAM México.

G. Gurrola, A. Alagón C. L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2002 Immunogen, Anti-Venom and Vaccine Against the Venom of the Black Widow Spider.UNAM Estados Unidos, Europa EP00980069.9 y Canadá 2,397,731.

B. Selisko, B. Becerril F. Zamudio, L. D. Possani A. Ramírez y C. García 2001 Primary sequence and cDNA of insecticidally effective toxins from scorpions of the genus Centruroides.UNAM Estados Unidos.

L. D. Possani, B. Becerril y A. F. Licea N 2001 ADNc y fragmento Fab del anticuerpo BCF2 y su utilización en composiciones farmacéuticas neutralizantes de veneno de alacrán.UNAM México.

G. Gurrola B., A. Alagón C., L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2000 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM PCT.

C. Noeske-Jungblut, W.D. Schleuning, A. Alagon, L.D Possani, D.A. Cuevas-Aguirre, P. Donner, B. Haendler y U. Hechler 1999 Thormbin inhibitor from saliva protostomia.Schering Estados Unidos.

A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 1999 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM-Inst. de QuÍmica Bioorgánica México. (en trámite)

C. Noeske-jungbut, B. Haendler, J.R. kraestzschmar, W.D. Schlenuning, A. Alagon, L.D. possani, yD.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Estados Unidos.

C. Noeske-jungbut, B. Haendler, J.R. kraestzschmar, W.D. Schlenuning, A. Alagon, L.D. possani, y D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.

C. Noeske-jungbut B. Haendler J.R. kraestzschmar W.D. Schlenuning A. Alagon L.D. possani D.A Cuevas-Aguirre 1998 Collagen-induced platelet aggration inhibitor.Schering Europa.

C. Noeske-jungblut W.D. Schelunig A. Alagon L.D. Possani D.A. Cuevas-Aguirre P. Donner B. Haendler y U. Hechler 1997 Clotting inhibitor made from protostomia saliva.Schering Europa.

L.D. Possani, B. Becerril, M. Corona, F. Ingerborg, F. Zamudio, E.S. Calderón, P. Litton y B.M. Martin 1995 Producao de peptideos de escorpioes Tityus serrulatus, Tityus bahiensis e Tityus stigmurus, e respectiva inmunizacao de cavalo, visando a obtencao de soros antiescorpionicos.UNAM-Fundación Butantan Brasil.

L.D. Possani P. G. Gurrola B. M.A.A. Bayón C. M. Sitges B. 1991 Procedimiento, diseño y síntesis para la obtención de péptidos sintéticos de estructura (Ax)N-(As)N-As, capaces de formar derivados beta-carbonilos para sustratos fluorogénicos de enzimas hidrolasas.UNAM México. (en trámite)

L D. Possani P. G. Gurrola B. M. A. A. Bayón C y M. Sitges B. 1990 Synthetic Noxiustoxin related peptides.UNAM Estados Unidos.

* Indica publicación con otra institución de adscripción



UNAM | UNAM Morelos | Mapa del Sitio | Biblioteca Virtual de Biotecnología | Acerca de | Servicios | e-mail | Publicaciones
Docencia | Seminarios | Nuestra Gente | Biblioteca | Libros y documentos en línea | Localización | Informes Institucionales | Estancias para estudiantes de Licenciatura
Uso interno. | Página Principal
4283 : 25626