Dr. Mario Soberón Chávez Departamento de Microbiología Molecular
Teléfonos Oficina +52 (777) 329-1618desde el D.F. 562-27618 red UNAM 27618 Laboratorio +52 (777) 329-1624 |
- Licenciatura: Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-UNAM (1983)
- Maestría: en Investigacion Biomedica Basica, CIFN-UNAM (1985)
- Doctorado: en Investigacion Biomedica Basica, CIFN-UNAM (1988)
- Medalla "Gabino Barreda" por estudios de Maestría (1987)
- Mencion honorífica en examen de Licenciatura (1983)
- Mencion honorífica en examen de Maestría (1985)
- Mencion honorífica en examen de Doctorado (1989)
- Plant genetics Systems, N.V. Gante, Belgica (II-90 a IV-91)
Premio de Investigación en Biotecnología Agrícola AgroBIO (2006)
M.C. Pablo Emiliano Canton M.C. Josue Ocelotl Biol. Alan Israel Jimenez
Flores-Escobar,B. Rodriguez-Magadan,H. Bravo,A. Soberon,M. Gomez,I.
2013. Manduca sexta Aminopeptidase-N and Alkaline phosphatase have a differential role in the mode of action of Cry1Aa, Cry1Ab and Cry1Ac toxins from Bacillus thuringiensis Appl Environ Microbiol, May 17. [Epub ahead of print], .
Bedoya-Perez,L.P. Cancino-Rodezno,A. Flores-Escobar,B. Soberon,M. Bravo,A.
2013. Role of UPR Pathway in Defense Response of Aedes aegypti against Cry11Aa Toxin from Bacillus thuringiensis Int J Mol Sci, 14, 8467-8478.
Zuniga-Navarrete,F. Gomez,I. Pena,G. Bravo,A. Soberon,M.
2013. A Tenebrio molitor GPI-anchored alkaline phosphatase is involved in binding of Bacillus thuringiensis Cry3Aa to brush border membrane vesicles Peptides, 41, 81-86.
Soberon,M. Lopez-Diaz,J.A. Bravo,A.
2013. Cyt toxins produced by Bacillus thuringiensis: A protein fold conserved in several pathogenic microorganisms Peptides, 41, 87-93.
Pardo-Lopez,L. Soberon,M. Bravo,A.
2013. Bacillus thuringiensis insecticidal 3-domain Cry toxins: Mode of action, insect resistance and consequences for crop protection FEMS Microbiol Rev, 37, 3-22.
Bravo,A. Gomez,I. Porta,H. Garcia-Gomez,B.I. Rodriguez-Almazan,C. Pardo,L. Soberon,M.
2013. Evolution of Bacillus thuringiensis Cry toxins insecticidal activity Microb Biotechnol, 6, 17-26.
Jimenez,A.I. Reyes,E.Z. Cancino-Rodezno,A. Bedoya-Perez,L.P. Caballero-Flores,G.G. Muriel-Millan,L.F. Likitvivatanavong,S. Gill,S.S. Bravo,A. Soberon,M.
2012. Aedes aegypti alkaline phosphatase ALP1 is a functional receptor of Bacillus thuringiensis Cry4Ba and Cry11Aa toxins Insect Biochem Mol Biol, 42, 683-689.
Soberon,M. Rodriguez-Almazan,C. Munoz-Garay,C. Pardo-Lopez,L. Porta,H. Bravo,A.
2012. Bacillus thuringiensis Cry and Cyt mutants useful to counter toxin action in specific environments and to overcome insect resistance in the field Pesticide Biochemistry And Physiology, 104, 111-117.
Cancino-Rodezno,A. Lozano,L. Oppert,C. Castro,J.I. Lanz-Mendoza,H. Encarnacion,S. Evans,A.E. Gill,S.S. Soberon,M. Jurat-Fuentes,J.L. Bravo,A.
2012. Comparative Proteomic Analysis of Aedes aegypti Larval Midgut after Intoxication with Cry11Aa Toxin from Bacillus thuringiensis PLoS ONE, 7, e37034.
Rodriguez-Almazan,C. Reyes,E.Z. Zuniga-Navarrete,F. Munoz-Garay,C. Gomez,I. Evans,A.M. Likitvivatavanong,S. Bravo,A. Gill,S.S. Soberon,M.
2012. Cadherin binding is not a limiting step for Bacillus thuringiensis subs. israelensis Cry4Ba toxicity to Aedes aegypti larvae Biochem J, 443, 711-717.
Porta,H. Munoz-Minutti,C. Soberon,M. Bravo,A.
2011. Induction of Manduca sexta Larvae Caspases Expression in Midgut Cells by Bacillus thuringiensis Cry1Ab Toxin Psyche: A Journal of Entomology, , Article ID 938249.
Tabashnik,B.E. Huang,F. Ghimire,M.N. Leonard,B.R. Siegfried,B.D. Rangasamy,M. Yang,Y. Wu,Y. Gahan,L.J. Heckel,D.G. Bravo,A. Soberon,M.
2011. Efficacy of genetically modified Bt toxins against insects with different genetic mechanisms of resistance Nat.Biotechnol, 29, 1128-1131.
Porta,H. Jimenez,G. Cordoba,E. Leon,P. Soberon,M. Bravo,A.
2011. Tobacco plants expressing the Cry1AbMod toxin suppress tolerance to Cry1Ab toxin of Manduca sexta cadherin-silenced larvae Insect Biochem Mol Biol, 41, 513-519.
Carmona,D. Rodriguez-Almazan,C. Munoz-Garay,C. Portugal,L. Perez,C. de Maagd,R.A. Bakker,P. Soberon,M. Bravo,A.
2011. Dominant Negative Phenotype of Bacillus thuringiensis Cry1Ab, Cry11Aa and Cry4Ba Mutants Suggest Hetero-Oligomer Formation among Different Cry Toxins PLoS ONE, 6, e19952.
Zavala,L.E. Pardo-Lopez,L. Canton,P.E. Gomez,I. Soberon,M. Bravo,A.
2011. Domains II and III of Bacillus thuringiensis Cry1Ab toxin remain exposed to the solvent after insertion of part of domain I into the membrane J Biol Chem, 286, 19109-19117 [Correction: vol 287 p 34499].
Bravo,A. Likitvivatanavong,S. Gill,S.S. Soberon,M.
2011. Bacillus thuringiensis: A story of a successful bioinsecticide Insect Biochem Mol Biol, 41, 423-431.
Likitvivatanavong,S. Chen,J. Evans,A.M. Bravo,A. Soberon,M. Gill,S.S.
2011. Multiple Receptors as Targets of Cry Toxins in Mosquitoes J Agric.Food Chem, 59, 2829-2838.
Rodriguez-Almazan,C. Ruiz de Escudero,I. Canton,P.E. Munoz-Garay,C. Perez,C. Gill,S.S. Soberon,M. Bravo,A.
2011. The amino- and carboxyl-terminal fragments of the Bacillus thuringiensis Cyt1Aa toxin have differential roles on toxin oligomerization and pore formation Biochemistry, 50, 388-396.
Terenius,O. Papanicolaou,A. Garbutt,J.S. Eleftherianos,I. Huvenne,H. Sriramana,K. Albrechtsen,M. An,C. Aymeric,J.L. Barthel,A. Bebas,P. Bitra,K. Bravo,A. Chevalier,F. Collinge,D.P. Crava,C.M. de Maagd,R.A. Duvic,B. Erlandson,M. Faye,I. Felfoldi,G. Fujiwara,H. Futahashi,R. Gandhe,A.S. Gatehouse,H.S. Gatehouse,L.N. Giebultowicz,J. Gomez,I. Grimmelikhuijzen,C.J. Groot,A.T. Hauser,F. Heckel,D.G. Hegedus,D.D. Hrycaj,S. Huang,L. Hull,J.J. Iatrou,K. Iga,M. Kanost,M.R. Kotwica,J. Li,C. Li,J. Liu,J. Lundmark,M. Matsumoto,S. Meyering-Vos,M. Millichap,P.J. Monteiro,A. Mrinal,N. Niimi,T. Nowara,D. Ohnishi,A. Oostra,V. Ozaki,K. Papakonstantinou,M. Popadic,A. Rajam,M.V. Saenko,S. Simpson,R.M. Soberon,M. Strand,M.R. Tomita,S. Toprak,U. Wang,P. Wee,C.W. Whyard,S. Zhang,W. Nagaraju,J. Ffrench-Constant,R.H. Herrero,S. Gordon,K. Swevers,L. Smagghe,G. et al
2011. RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design J Insect Physiol, 57, 231-245.
Likitvivatanavong,S. Chen,J. Bravo,A. Soberon,M. Gill,S.S.
2011. Cadherin, Alkaline Phosphatase, and Aminopeptidase N as Receptors of Cry11Ba Toxin from Bacillus thuringiensis subsp. jegathesan in Aedes aegypti? Appl Environ Microbiol, 77, 24-31.
Porta,H. Cancino-Rodezno,A. Soberon,M. Bravo,A.
2011. Role of MAPK p38 in the cellular responses to pore-forming toxins Peptides, 32, 601-606.
Canton,P.E. Reyes,E.Z. Escudero,I.R. Bravo,A. Soberon,M.
2011. Binding of Bacillus thuringiensis subsp. israelensis Cry4Ba to Cyt1Aa has an important role in synergism Peptides, 32, 595-600.
Gomez,I. Arenas,I. Pacheco,S. Bravo,A. Soberon,M.
2010. New Insights into the Mode of Action of Cry1Ab Toxin Used in Transgenic Insect-resistant Crops Southwestern Entomologist, 35, 387-390.
Munoz-Garay,C. Soberon,M. Bravo,A.
2010. Mode of Action of Bacillus thuringiensis-Genetically Modified Cry1AbMod and Cry1AcMod Toxins Role of Alkaline pH in Toxin Oligomerization Southwestern Entomologist, 35, 383-386.
Fernandez-Luna,M.T. Tabashnik,B.E. Lanz-Mendoza,H. Bravo,A. Soberon,M. Miranda-Rios,J.
2010.
Single concentration tests show synergism among Bacillus thuringiensis subsp. israelensis toxins against the malaria vector mosquito Anophelesalbimanus J Invertebr.Pathol., 104, 231-233.
Arenas,I. Bravo,A. Soberon,M. Gomez,I.
2010.
Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin J Biol Chem, 285, 12497-503.
Fernandez-Luna,M.T. Lanz-Mendoza,H. Gill,S.S. Bravo,A. Soberon,M. Miranda-Rios,J.
2010.
An alpha-amylase is a novel receptor for Bacillus thuringiensis ssp. israelensis Cry4Ba and Cry11Aa toxins in the malaria vector mosquito Anopheles albimanus (Diptera: Culicidae) Environ Microbiol, 12, 746-757.
Cancino-Rodezno,A. Alexander,C. Villasenor,R. Pacheco,S. Porta,H. Pauchet,Y. Soberon,M. Gill,S.S. Bravo,A.
2010.
The mitogen-activated protein kinase p38 is involved in insect defense against cry toxins from Bacillus thuringiensis Insect Biochem Mol Biol, 40, 58-63.
Cancino-Rodezno,A. Porta,H. Soberon,M. Bravo,A.
2009.
Defense and death responses to pore forming toxins Biotechnology and Genetic Engineering Reviews, 26, 82.
Munoz-Garay,C. Rodriguez-Almazan,C. Aguilar,J.N. Portugal,L. Gomez,I. Saab-Rincon,G. Soberon,M. Bravo,A.
2009.
Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti Appl Environ Microbiol, 75, 7548-7550 [Correction vol 79 (5) p 1762].
Pacheco,S. Gomez,I. Arenas,I. Saab-Rincon,G. Rodriguez-Almazan,C. Gill,S.S. Bravo,A. Soberon,M.
2009.
Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping-pong" binding mechanism with Manduca sexta aminopetidase-N and cadherin receptors J Biol Chem, 284, 32750-32757.
Chen,J. Aimanova,K.G. Fernandez,L.E. Bravo,A. Soberon,M. Gill,S.S.
2009.
Aedes aegypti cadherin serves as a putative receptor of the Cry11Aa toxin from Bacillus thuringiensis subsp. israelensis Biochem J, 424, 191-200.
Fernandez,L.E. Martinez-Anaya,C. Lira,E. Chen,J. Evans,A. Hernandez-Martinez,S. Lanz-Mendoza,H. Bravo,A. Gill,S.S. Soberon,M.
2009.
Cloning and epitope mapping of Cry11Aa-binding sites in the Cry11Aa-receptor alkaline phosphatase from Aedes aegypti Biochemistry, 48, 8899-8907.
Franklin,M.T. Nieman,C.L. Janmaat,A.F. Soberon,M. Bravo,A. Tabashnik,B.E. Myers,J.H.
2009.
Modified Bacillus thuringiensis toxins and a hybrid B. thuringiensis strain counter greenhouse-selected resistance in Trichoplusia ni Appl Environ Microbiol, 75, 5739-5741.
Munoz-Garay,C. Portugal,L. Pardo-Lopez,L. Jimenez-Juarez,N. Arenas,I. Gomez,I. Sanchez-Lopez,R. Arroyo,R. Holzenburg,A. Savva,C.G. Soberon,M. Bravo,A.
2009.
Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects Biochimica Et Biophysica Acta-Biomembranes, 1788, 2229-2237.
Rodriguez-Almazan,C. Zavala,L.E. Munoz-Garay,C. Jimenez-Juarez,N. Pacheco,S. Masson,L. Soberon,M. Bravo,A.
2009.
Dominant negative mutants of Bacillus thuringiensis Cry1Ab toxin function as anti-toxins: demonstration of the role of oligomerization in toxicity PLoS ONE, 4, e5545-[Erratum 2013 8 (2)].
Soberon,M. Gill,S.S. Bravo,A.
2009.
Signaling versus punching hole: How do Bacillus thuringiensis toxins kill insect midgut cells? Cell Mol Life Sci., 66, 1337-1349.
Pacheco,S. Gomez,I. Gil1 SS Bravo,A. Soberon,M.
2009.
Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation Peptides, 30, 583-588.
Pardo-Lopez,L. Munoz-Garay,C. Porta,H. Rodriguez-Almazan,C. Soberon,M. Bravo,A.
2009.
Strategies to improve the insecticidal activity of Cry toxins from Bacillus thuringiensis Peptides, 30, 589-595.
Zuniga-Navarrete,F. Bravo,A. Soberon,M. Gomez,I. 2012. Role of GPI-anchored membrane receptors in the mode of action of Bacillus thuringiensis Cry toxins en: Larramendy,M.L. Integrated Pest Management and Pest Control- Current and Future Tactics. Intech. pags. 551-566
Pacheco,S. Soberon,M. 2012. Phage display: Fundamentals and applications en: Gomez,I. Tools to Understand Protein-Protein Interactions. Kerala. Transworld Research Network. 143
Soberon,M. Bravo,A. 2011. Control de insectos con Bacillus thuringiensis, un método efectivo y compatible con el ambiente en: V CICLO MUJER CIENCIA. Mexico,D.F:. Editores Mujeres en la Ciencia. pags. 1-11
Bravo,A. del Rincon-Castro,M.C. Ibarra,J.E. Soberon,M. 2011. Towards a healthy control of insect pest: Potential use of Microbial insecticides en: Fernandez-Bolanos,J.G. Green trends in insect control. London. Royal Society of Chemistry. pags. 266-299
Soberon,M. Pardo,L. Munoz-Garay,C. Sanchez,J. Gomez,I. Porta,H. Bravo,A. 2010. Pore Formation by Cry Toxins en: Lakey,J. Proteins: Membrane Binding and Pore Formation (serie Advances in Experimental Medicine and Biology vol 677). Austin, TX. Landes Bioscience y Springer. pags. 127-142
Bravo,A. Gill,S.S. Soberon,M. 2010. Bacillus thuringiensis Mechanisms and Use with addendum 2010 en: Gill,S.S. Insect Control Biological and Synthetic Agents. Elsevier. pags. 247-282
L. Pardo-López, E. B. Tabashnik, M. Soberón-Chavéz y M. A. Bravo-De La Parra 2009 Supresión de resistencia en insectos hacia las toxinas Cry de Bacillus thuringiensis utilizando toxinas que no requieren al receptor caderina.UNAM Europa, China, Canadá, India, Brasil y México (Números de solicitud pendientes). (en trámite)
M. Soberon M y M. A. Bravo 2008 Novel bacterial proteins with pesticidal activity.UNAM China 200680032864.5, Brasil PI0613111-5, India 200800272, Estados Unidos sin número y Europa 06795076.6. (en trámite)
L. Pardo-López, E. B. Tabashnik, M. Soberón-Chavéz y M. A. Bravo-De La Parra 2007 Supresión de resistencia en insectos hacia las toxinas Cry de Bacillus thuringiensis utilizando toxinas que no requieren al receptor caderina.UNAM PCT. (en trámite)
M. Soberon Ch. y M. A. Bravo de la P 2006 Novel bacterial proteins with pesticidal activity.UNAM PCT y Canadá 2625061. (en trámite)
M. Soberon y M. A. Bravo 2005 Novel bacterial proteins with pesticidal activity.UNAM Estados Unidos.
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