. Instituto de Biotecnologia UNAM

IBT-UNAM : Dra. Marcela Ayala Aceves

Dra. Marcela Ayala Aceves

Líder Académico »» Grupo
Investigador
Tutor de Maestría y Doctorado
Nivel I del SNI
Departamento de Ingeniería Celular y Biocatálisis

Líneas de investigación

email: maa @ibt.unam.mx
Teléfonos

Laboratorio +52 (777) 329-1619
desde la CDMX 562-27619
red UNAM 27619

Distinción Universidad Nacional para Jóvenes Académicos (DUNJA) UNAM (2011)
Premio Alfredo Sanchez Marroquin a la mejor tesis de doctorado Sociedad Mexicana de Biotecnologia y Bioingenieria (2003)

Estudiantes

Biol. Gustavo Alonso Alvarado

Biol. Adrian Jesus Quintana

Ing. Alina Elizabeth Torres

Q.F.B. Raul Mireles

José Antonio Galeana

Biol. Claudia Daniela Vazquez

Publicaciones recientes

Arregui,L. Ayala,M. Gomez-Gil,X. Gutierrez-Soto,G. Hernandez-Luna,C.E. Herrera de Los,S.M. Levin,L. Rojo-Dominguez,A. Romero-Martinez,D. Saparrat,M.C.N. Trujillo-Roldan,M.A. Valdez-Cruz,N.A. 2019. Laccases: structure, function, and potential application in water bioremediation Microbial Cell Factories, 18, 200.

Jimenez-Sanchez,M. Perez-Morales,R. Goycoolea,F.M. Mueller,M. Praznik,W. Loeppert,R. Bermudez-Morales,V. Zavala-Padilla,G. Ayala,M. Olvera,C. 2019. Self-assembled high molecular weight inulin nanoparticles: Enzymatic synthesis, physicochemical and biological properties Carbohydrate Polymers, 215, 160-169.

Vazquez,M.A. Valino-Cabrera,E.C. Ayala-Aceves,M. Folch-Mallol,J.L. 2019. Cellulolytic and ligninolytic potential of new strains of fungi for the conversion of fibrous substrates Biotechnology Research and Innovation, 3, 177-186.

Avelar,M. Pastor,N. Ramirez-Ramirez,J. Ayala,M. 2018. Replacement of oxidizable residues predicted by QM-MM simulation of a fungal laccase generates variants with higher operational stability Journal of Inorganic Biochemistry, 178, 125-133.

Avelar,M. Olvera,C. Aceves-Zamudio,D. Folch,J.L. Ayala,M. 2017. Recombinant expression of a laccase from Coriolopsis gallica in Pichia pastoris using a modified alpha-factor preproleader Protein Expression and Purification, 136, 14-19.

Sierra,E. Miranda-Molina,A. Castillo,E. Hu,H. Ayala,M. 2017. Chemoenzymatic synthesis of poly(phenylene disulfides) with insulating properties and resistant to high temperatures Journal of Chemical Technology & Biotechnology, 92, 2691-2698.

Sahare,P. Ayala,M. Vazquez-Duhalt,R. Pal,U. Loni,A. Canham,L.T. Osorio,I. Agarwal,V. 2016. Enhancement of Peroxidase Stability Against Oxidative Self-Inactivation by Co-immobilization with a Redox-Active Protein in Mesoporous Silicon and Silica Microparticles Nanoscale Research Letters, 11, 417.

Ayala,M. Segovia,L. Torres,E. 2016. Halogenases: A Biotechnological Alternative For The Synthesis Of Halogenated Pharmaceuticals Mini Reviews in Medicinal Chemistry, 16, 1100-1111.

Balcazar-Lopez,E. Mendez-Lorenzo,L.H. Batista-Garcia,R.A. Esquivel-Naranjo,U. Ayala,M. Kumar,V.V. Savary,O. Cabana,H. Herrera-Estrella,A. Folch-Mallol,J.L. 2016. Xenobiotic Compounds Degradation by Heterologous Expression of a Trametes sanguineus Laccase in Trichoderma atroviride PLoS ONE, 11, e0147997.

Garcia-Guevara,F. Avelar,M. Ayala,M. Segovia,L. 2015. Computational Tools Applied to Enzyme Design Biocatalysis, 1, 109-117.

Juarez-Moreno,K. Ayala,M. Vazquez-Duhalt,R. 2015. Antioxidant Capacity of Poly(Ethylene Glycol) (PEG) as Protection Mechanism Against Hydrogen Peroxide Inactivation of Peroxidases Applied Biochemistry and Biotechnology, 177, 1364-1373.

Hernandez-Lopez,E.L. Ayala,M. Vazquez-Duhalt,R. 2015. Microbial and Enzymatic Biotransformations of Asphaltenes Petroleum Science and Technology, 33, 1017-1029.

Salcedo,K. Torres-Ramirez,E. Haces,I. Ayala,M. 2015. Halogenation of Î²-estradiol by a rationally designed mesoporous biocatalyst based on chloroperoxidase Biocatalysis, 1, .

Sahare,P. Ayala,M. Vazquez-Duhalt,R. Agrawal,V. 2014. Immobilization of peroxidase enzyme onto the porous silicon structure for enhancing its activity and stability Nanoscale Research Letters, 9, 409.

Vazquez-Duhalt,R. Aguila,S.A. Arrocha,A.A. Ayala,M. 2014. QM/MM Molecular Modeling and Marcus Theory in the Molecular Design of Electrodes for Enzymatic Fuel Cells ChemElectroChem, 1, 496-513.

Vidal-Limon,A. Aguila,S. Ayala,M. Batista,C.V. Vazquez-Duhalt,R. 2013. Peroxidase activity stabilization of cytochrome P450(BM3) by rational analysis of intramolecular electron transfer Journal of Inorganic Biochemistry, 122, 18-26.

Ayala,M. Hernandez-Lopez,E.L. Perezgasga,L. Vazquez-Duhalt,R. 2012. Reduced coke formation and aromaticity due to chloroperoxidase-catalyzed transformation of asphaltenes from Maya crude oil Fuel, 92, 245-249.

Uribe-Alvarez,C. Ayala,M. Perezgasga,L. Naranjo,L. Urbina,H. Vazquez-Duhalt,R. 2011. First evidence of mineralization of petroleum asphaltenes by a strain of Neosartorya fischeri Microbial Biotechnology, 4, 663-672.

Ayala,M. Batista,C.V. Vazquez-Duhalt,R. 2011. Heme destruction, the main molecular event during the peroxide-mediated inactivation of chloroperoxidase from Caldariomyces fumago Journal of Biological Inorganic Chemistry, 16, 63-68.

Ayala,M. Pickard,M.A. Vazquez-Duhalt,R. 2008. Fungal enzymes for environmental purposes, a molecular biology challenge Journal of Molecular Microbiology and Biotechnology, 15, 172-180.

Ayala,M. Verdin,J. Vazquez-Duhalt,R. 2007. The prospects for peroxidase-based biorefining of petroleum fuels Biocatalysis And Biotransformation, 25, 114-129.

Ayala,M. Roman,R. Vazquez-Duhalt,R. 2007. A catalytic approach to estimate the redox potential of heme-peroxidases Biochemical and Biophysical Research Communications, 357, 804-808.

Aburto,J. Ayala,M. Bustos-Jaimes,I. Montiel,C. Terres,E. Dominguez,J.M. Torres,E. 2005. Stability and catalytic properties of chloroperoxidase immobilized on SBA-16 mesoporous materials Microporous and Mesoporous Materials, 83, 193-200 * .

Ayala,M. Torres,E. 2004. Enzymatic activation of alkanes: constraints and prospective Applied Catalysis A-General, 272, 1-13 * .

Ayala,M. Horjales,E. Pickard,M.A. Vazquez-Duhalt,R. 2002. Cross-linked crystals of chloroperoxidase Biochemical and Biophysical Research Communications, 295, 828-831.

Valderrama,B. Ayala,M. Vazquez-Duhalt,R. 2002. Suicide inactivation of peroxidases and the challenge of engineering more robust enzymes Chemistry and Biology, 9, 555-565.

Ayala-Aceves,M. Baratto,M.C. Basosi,R. Vazquez-Duhalt,R. Pogni,R. 2001. Spectroscopic characterization of a manganese-lignin peroxidase hybrid isozyme produced by Bjerkandera adusta in the absence of manganese: evidence of a protein centred radical by hydrogen peroxide Journal Of Molecular Catalysis B-Enzymatic, 16, 159-167.

Vazquez-Duhalt,R. Ayala,M. Marquez-Rocha,F.J. 2001. Biocatalytic chlorination of aromatic hydrocarbons by chloroperoxidase of Caldariomyces fumago Phytochemistry, 58, 929-933.

Ayala,M. Robledo,N.R. Lopez-Munguia,A. Vazquez-Duhalt,R. 2000. Substrate specificity and ionization potential in chloroperoxidase-catalyzed oxidation of diesel fuel Environmental Science & Technology, 34, 2804-2809.

Ayala,M. Tinoco,R. Hernandez,V. Bremauntz,P. Vazquez-Duhalt,R. 1998. Biocatalytic oxidation of fuel as an alternative to biodesulfurization Fuel Processing Technology, 57, 101-111.

Libros y capítulos recientes

Ayala,M. Vazquez-Duhalt,R. Morales,M. Le Borgne,S. 2017. Application of Microorganisms to the Processing and Upgrading of Crude Oil and Fractions en: Lee,S.Y. Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals. Handbook of Hydrocarbon and Lipid Microbiology. Cham. Springer International Publishing. pags. 1-36

Ayala,M. Torres,E. 2016. Chapter 13 Peroxidases as Potential Industrial Biocatalysts en: Dunford,B. Heme Peroxidases. Cambridge. The Royal Society of Chemistry. pags. 309-333

Torres,E. Ayala,M. 2013. Biocatalysis by Metalloenzymes en: Poeppelmeier.K. Comprehensive Inorganic Chemistry II (Second Edition) Vol 6 Homogeneous Catalytic Applications. Amsterdam. Elsevier. pags. 685-735

Le Borgne,S. Ayala,M. 2010. Microorganisms utilizing sulfur-containing hydrocarbons en: Timmis,K.N. Handbook of Hydrocarbon and Lipid Microbiology. Heidelberg. Springer. pags. 2129-2141

Morales,M. Ayala,M. Vazquez-Duhalt,R. Le Borgne,S. 2010. Application of microorganisms to the processing and upgrading of crude oil and fractions en: Timmis,K.N. Handbook of Hydrocarbon and Lipid Microbiology. Heidelberg. Springer. pags. 2767-2785

Ayala,M. 2010. Redox potential of heme peroxidases en: *maa Biocatalysis based on heme peroxidases . Peroxidases as Potential Industrial Biocatalysts. Springer. pags. 61-77

Ayala,M. Torres,E. 2010. Biocatalysis Based on Heme Peroxidases Peroxidases as Potential Industrial Biocatalysts Introduction en: *maa Biocatalysis Based on Heme Peroxidases: Peroxidases As Potential Industrial Biocatalysts. Springer. pags. 1-4

Torres,E. Ayala,M. 2010. Biocatalysis based on heme peroxidases Springer-Verlag. 358 p.

Ayala,M. Vazquez-Duhalt,R. 2004. Enzymatic catalysis on petroleum products en: *vazqduh Petroleum Biotechnology: Developments and Perspectives. Elsevier Science. pags. 67-111

Valderrama,B. Ayala,M. Vazquez-Duhalt,R. 2003. Ambiente, energía y la nueva industria. en: *agustin Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII. Mexico,D.F.. El Colegio Nacional. pags. 67-91

Otras Publicaciones

Ayala-Aceves,M. 2019. Enzobioticos. Enriqueciendo la caja de herramientas para esquivar la resistencia a antibioticos Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 18, 24-27.

Ayala-Aceves,M. Castillo-Rosales,E. 2015. Enfoque molecular y computacional de la biocatálisis Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 1, 22.

Olvera-Carranza,C. Ayala-Aceves,M. 2015. Del gen al producto Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 2, 25-26.

Cruz,J.C. Garcia,J. Ayala,M. 2015. Enzymatic oxidation of volatile malodorous organosulfur compounds in a two-phase reactor TIP revista especializada en Ciencias Quimico-Biologicas, 18, 5-12.

Ramirez-Ramirez,J. Ayala-Aceves,M. 2014. Enzimas: ¿qué son y cómo funcionan Revista Digital Universitaria, 15, art 91.

Roman,R. Torres-Duarte,C. Ayala,M. Vazquez-Duhalt,R. 2010. Producción a escala piloto de lacasa de Coriolopsis gallica Revista Mexicana de Micología, 32, 19-27.

Ayala,M. Vazquez-Duhalt,R. 2003. Cristales cataliticos de una peroxidasa Biotecnologia, 8, 22-34.

* Indica publicación con otra institución de adscripción