IBT-UNAM : Dra. Gloria Saab Rincon
- Licenciatura: Química Farmaceutica Biologa, Fac. de Química-UNAM (1979-1984)
Miembro de la Academia Mexicana de Ciencias (2005)
Estudiantes Ing. Javier Burgos
Biol. Oscar Alberto Fernandez
M.C. Juanita Damián "Estudio del efecto de la topología en el plegamiento de la triosafosfato isomerasa monomérica de Trypanosoma brucei mediante permutación circular"
Q.F.B. Jorge Luis Jimenez
M.C. Rodrigo Arreola
M.C. Emma Liliana Arévalo
Publicaciones recientes
Carcamo,E. Roldan-Salgado,A. Osuna,J. Bello San-Martin,I. Yanez,J.A. Saab-Rincon,G. Viadiu,H. Gaytan,P.
2017. Spiked Genes: A Method to Introduce Random Point Nucleotide Mutations Evenly throughout an Entire Gene Using a Complete Set of Spiked Oligonucleotides for the Assembly ACS Omega, 2, 3183-3191.
Guzman-Luna,V. Olvera-Rodriguez,L. Bustamante-Villalobos,P. Saab-Rincon,G.
2017. Characterization of a New Allelic Variant of Triosephosphate Isomerase from the LNCaP Human Prostate Cancer Cell Line: Enzyme Inhibition and Spectroscopic Studies Current Enzyme Inhibition, 13, 1-7.
Cuevas-Velazquez,C.L. Saab-Rincon,G. Reyes,J.L. Covarrubias,A.A.
2016. The unstructured N-terminal region of Arabidopsis group 4 Late Embryogenesis Abundant Proteins (LEA) is required for folding and for chaperone-like activity under water deficit Journal of Biological Chemistry, 291, 10893-10903.
Carcamo-Noriega,E.N. Saab-Rincon,G.
2016. Identification of fibrillogenic regions in human triosephosphate isomerase PeerJ, 4, e1676.
Montero-Moran,G.M. Sampedro,J.G. Saab-Rincon,G. Cervantes-Gonzalez,M.A. Huerta-Ocampo,J.A. De Leon-Rodriguez,A. Barba de la Rosa,A.P.
2015. Biochemical and Molecular Characterization of a Novel Cu/Zn Superoxide Dismutase from Amaranthus hypochondriacus L.: an Intrinsically Disordered Protein Applied Biochemistry and Biotechnology, 176, 2328-2345.
Strompen,S. Miranda-Molina,A. Lopez-Munguia,A. Castillo,E. Saab-Rincon,G.
2015. Acceptor-induced modification of regioselectivity in CGTase-catalyzed glycosylations of p-nitrophenyl-glucopyranosides Carbohydrate Research, 404, 46-54.
Rivera-Najera,L.Y. Saab-Rincon,G. Battaglia,M. Amero,C. Pulido,N.O. Garcia-Hernandez,E. Solorzano,R.M. Reyes,J.L. Covarrubias,A.A.
2014. A Group 6 Late Embryogenesis Abundant Protein from Common Bean is a Disordered Protein with Extended Helical Structure and Oligomer-Forming Properties Journal of Biological Chemistry, 289, 31995-32009.
Bushey,D.F. Bannon,G.A. Delaney,B.F. Graser,G. Hefford,M. Jiang,X. Lee,T.C. Madduri,K.M. Pariza,M. Privalle,L.S. Ranjan,R. Saab-Rincon,G. Schafer,B.W. Thelen,J.J. Zhang,J.X. Harper,M.S.
2014. Characteristics and Safety Assessment of Intractable Proteins in Genetically Modified Crops Regulatory Toxicology and Pharmacology, 69, 154-170.
Hernandez-Moreno,A.V. Villasenor,F. Medina-Rivero,E. Perez,N.O. Flores-Ortiz,L.F. Saab-Rincon,G. Luna-Barcenas,G.
2014. Kinetics and conformational stability studies of recombinant leucine aminopeptidase International Journal of Biological Macromolecules, 64, 306-312.
Ochoa-Leyva,A. Montero-Moran,G. Saab-Rincon,G. Brieba,L.G. Soberon,X.
2013. Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold PLoS ONE, 8, e70582.
Figueroa-Angulo,E.E. Estrella-Hernandez,P. Salgado-Lugo,H. Ochoa-Leyva,A. Gomez-Puyou,A. Campos,S.S. Montero-Moran,G. Ortega-Lopez,J. Saab-Rincon,G. Arroyo,R. Benitez-Cardoza,C.G. Brieba,L.G.
2012. Cellular and biochemical characterization of two closely related triosephosphate isomerases from Trichomonas vaginalis Parasitology, 139, 1729-1738.
Osuna,J. Flores,H. Saab-Rincon,G.
2012. The beta1 domain of protein G can replace the chorismate mutase domain of the T-protein FEBS Letters, 586, 466-471.
Saab-Rincon,G. Olvera,L. Olvera,M. Rudino-Pinera,E. Benites,E. Soberon,X. Morett,E.
2012. Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase Journal of Molecular Biology, 416, 255-270.
Ochoa-Leyva,A. Barona-Gomez,F. Saab-Rincon,G. Verdel-Aranda,K. Sanchez,F. Soberon,X.
2011. Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability Journal of Molecular Biology, 411, 143-157.
Moreno,A. Damian-Almazo,J.Y. Miranda,A. Saab-Rincon,G. Gonzalez,F. Lopez-Munguia,A.
2010. Transglycosylation reactions of Thermotoga maritima [alpha]-amylase Enzyme and Microbial Technology, 46, 331-337.
Munoz-Garay,C. Rodriguez-Almazan,C. Aguilar,J.N. Portugal,L. Gomez,I. Saab-Rincon,G. Soberon,M. Bravo,A.
2009. Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti Applied and Environmental Microbiology, 75, 7548-7550 [Correction vol 79 (5) p 1762].
Pacheco,S. Gomez,I. Arenas,I. Saab-Rincon,G. Rodriguez-Almazan,C. Gill,S.S. Bravo,A. Soberon,M.
2009. Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping-pong" binding mechanism with Manduca sexta aminopetidase-N and cadherin receptors Journal of Biological Chemistry, 284, 32750-32757.
Ochoa-Leyva,A. Soberon,X. Sanchez,F. Arguello,M. Montero-Moran,G. Saab-Rincon,G.
2009. Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold Journal of Molecular Biology, 387, 949-964.
Saab-Rincon,G. Valderrama,B.
2009. Protein engineering of redox-active enzymes Antioxidants and Redox Signaling, 11, 167-192.
Damian-Almazo,J.Y. Lopez-Munguia A. Soberon-Mainero,X. Saab-Rincon,G.
2008. Role of the phenylalanine 260 residue in defining product profile and alcoholytic activity of the a-amylase AmyA from Thermotoga maritima Biologia, 63, 1035-1043.
Damian-Almazo,J.Y. Moreno,A. Lopez-Munguia,A. Soberon,X. Gonzalez-Munoz,F. Saab-Rincon,G.
2008. Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis Applied and Environmental Microbiology, 74, 5168-5177.
Morett,E. Saab-Rincon,G. Olvera,L. Olvera,M. Flores,H. Grande,R.
2008. Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity Journal of Molecular Biology, 376, 839-853.
Jimenez-Juarez,N. Munoz-Garay,C. Gomez,I. Saab-Rincon,G. Damian-Almazo,J.Y. Gill,S.S. Soberon,M. Bravo,A.
2007. Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae Journal of Biological Chemistry, 282, 21222-21229 [correction 2013 vol 288 (12) 8560].
Saab-Rincon,G. Mancera,E. Montero-Moran,G. Sanchez,F. Soberon,X.
2005. Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein Biomolecular Engineering, 22, 113-120.
Moreno,A. Saab-Rincon,G. Santamaria,R.I. Soberon,X. Lopez-Munguia,A.
2004. A more efficient starch degradation by the combination of hydrolase and transferase activities of alpha-amylase and cyclomaltodextrin glucanotransferase Starch-Starke, 56, 63-68.
Soberon,X. Fuentes-Gallego,P. Saab-Rincon,G.
2004. In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination FEBS Letters, 560, 167-172.
Rivera,M.H. Lopez-Munguia,A. Soberon,X. Saab-Rincon,G.
2003. alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity Protein Engineering, 16, 505-514.
Morett,E. Korbel,J.O. Rajan,E. Saab-Rincon,G. Olvera,L. Olvera,M. Schmidt,S. Snel,B. Bork,P.
2003. Systematic discovery of analogous enzymes in thiamin biosynthesis Nature Biotechnology, 21, 790-795.
Morett,E. Korbel,J.O. Rajan,E. Saab-Rincon,G. Olvera,L. Olvera,M. Schmidt,S. Snel,B. Bork,P.
2002. Discovery of Analogous Enzymes in Thiamin Biosynthesis by Anticorrelation Genome Informatics, 13, 365-366.
Garcia-Arellano,H. Valderrama,B. Saab-Rincon,G. Vazquez-Duhalt,R.
2002. High temperature biocatalysis by chemically modified cytochrome C Bioconjugate Chemistry, 13, 1336-1344.
Chanez-Cardenas,M.E. Fernandez-Velasco,D.A. Vazquez-Contreras,E. Coria,R. Saab-Rincon,G. Perez-Montfort,R.
2002. Unfolding of Triosephosphate Isomerase from Trypanosoma brucei: Identification of Intermediates and Insight into the Denaturation Pathway Using Tryptophan Mutants Archives of Biochemistry and Biophysics, 399, 117-129.
Saab-Rincon,G. Juarez,V.R. Osuna,J. Sanchez,F. Soberon,X.
2001. Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution Protein Engineering, 14, 149-155.
Santamaria,R.I. Del Rio,G. Saab,G. Rodriguez,M.E. Soberon,X. Lopez-Manguia,A.
1999. Alcoholysis reactions from starch with alpha-amylases FEBS Letters, 452, 346-350.
Saab-Rincon,G. Del Rio,G. Santamaria,R.I. Lopez-Munguia,A. Soberon,X.
1999. Introducing transglycosylation activity in a liquefying alpha-amylase FEBS Letters, 453, 100-106.
Saab-Rincon,G. Gualfetti,P.J. Matthews,C.R.
1996. Mutagenic and thermodynamic analyses of residual structure in the alpha subunit of tryptophan synthase Biochemistry, 35, 1988-1994 * .
Saab-Rincon,G. Froebe,C.L. Matthews,C.R.
1993. Urea-induced unfolding of the alpha subunit of tryptophan synthase: one-dimensional proton NMR evidence for residual structure near histidine-92 at high denaturant concentration Biochemistry, 32, 13981-13990 * .
Libros y capítulos recientes Damian-Almazo,J.Y. Saab-Rincon,G. 2013. Site directed-combinatorial mutagenesis for biocatalysis en: Figurski,D. Genetic Manipulation of DNA and Protein. Intech. pags. 303-330
Castillo,E. Saab-Rincon,G. Chavez-Mercado,C. 2012. Noncovalent interactions in proteins en: Gomez,I. Tools to Understand Protein-Protein Interactions. Kerala. Transworld Research Network. pags. 1-20
Saab-Rincon,G. Li,Y.G. Meyer,M. Carbone,M. Landwehr,M. Arnold,F.H. 2009. Protein Engineering by Structure-Guided (SCHEMA) Recombination en: Bornscheuer,U.T. Protein Engineering Handbook cap 20. Wiley-VHS. pags. 481-493
Morett,E. Saab-Rincon,G. Merino,E. Bork,P. Rajan,E. Olvera,L. Olvera,M. 2003. High rate of gene displacement in vitamin biosynthesis pathways en: Andrade,M.A. Bioinformatics and genomes: current perspectives. Norfolk,U.K.. Horizon Scientific Press. pags. 69-79
Morett.E. Saab,G. Olvera.L. Olvera.M Snel,B. Bork,P. 2002. Discovery of analogous enzymes in thiamin biosynthesis by anticorrelation en: Miyano,S. Genome Informatics 2002. Tokio. Universal Academy Press, Inc. pags. 365-366
Saab-Rincon,G. Del Rio,G. Santamaria,R. Diaz,M.L. Soberon,X. Lopez-Munguia,A. 2002. 54 en: Aguilera,J.M. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food. Boca Raton, Fla. CRC Press. pags. 913-924
Divulgación Carcamo-Noriega,E.N. Saab-Rincon,G.
2016. Tejiendo proteínas en fibras dañinas Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 7, 3-5.
Damian-Almazo,J.Y. Saab-Rincon,G.
2014. Las bacterias generadoras de enzimas que se encuentran hasta en los detergentes Hypatia, 47, .
Patentes J. E. Morett, L. Olvera R., M. Olvera R., E. Rajan-Koil M., G. Saab R., P. Bork, D. Korbe-Larz, S. Schmidt y D.H.P. Snel 2004 Bioinformatic Method.Copropiedad de la UNAM y el laboratorio Europeo de Biología Molecular PCT.
* Indica publicación con otra institución de adscripción
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