Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Enrique Rudiño Piñera


Dr. Enrique Rudiño Piñera

Secretario Académico

Líder Académico »» Grupo


Tutor de Maestría y Doctorado

Nivel III del SNI

Líneas de investigación



Oficina (52+55) 562-27673 ;

Oficina +52 (777) 329-1616
desde la CDMX 562-27616

red UNAM 27616
+52 (777) 311-4900 ext 246

Laboratorio +52 (777) 329-1610
desde la CDMX 562-27610

red UNAM 27610
+52 (777) 311-4900 ext 246

- Licenciatura: Química, Universidad La Salle, A.C. (1994)
- Maestría: Biotecnología, Facultad de Química, UNAM (1999)
- Doctorado: Ciencias (Bioquímicas), IBT, UNAM (2001)
- Medalla de plata Alfonso Caso (generación 1995)
- Laboratory of Molecular Biophysics, University of Oxford, Reino Unido (2003-2004) Visiting Scientist Fellowship from Royal Society, U.K. (2006)


Lic. Ulises Dantán

Biol. Cristhian Aristizabal

Angela Escudero

Biol. Nizaa Jimenez

Biol. Arisbeth Guadalupe Almeida

Lic. Jesús Lara

Biol. Elena Lizbeth Garcia

M.C. Yerli Marín

M.C. Ariadna Berenice Juarez

Ing. Alexis Omar Campuzano

Lic. Francisco Murphy

M.C Ruben Priego

Q.B.P. Alberto Venancio

Alfredo Rodríguez "Adaptaciones del Antígeno Nuclear de Células en Proliferación (PCNA) de Thermococcus gammatolerans a condiciones de extrema radiación."

Ing. Cristian Uriel Sanchez

José Ignacio Román

M.C. Ricardo Miranda

Dinorah Gallardo

Armando Avila

Publicaciones recientes

Flores-Ibarra,A. Campos-Escamilla,C. Guerra,Y. Rudino-Pinera,E. Demitri,N. Polntarrutti,M. Cuellar-Cruz,M. Moreno,A. 2018. Novel Devices for Transporting Protein Crystals to the Synchrotron Facilities and Thermal Protection of Protein Crystals Crystals, 8, .

Garcia-Magana,M.L. Gonzalez-Borrayo,J. Montalvo-Gonzalez,E. Rudino-Pinera,E. Sayago-Ayerdi,S.G. Salazar-Leyva,J.A. 2018. Isoelectric focusing, effect of reducing agents and inhibitors: partial characterization of proteases extracted from Bromelia karatas Applied Biological Chemistry, 61, 459-467.

Arreola,R. Villalpando,J.L. Puente-Rivera,J. Morales-Montor,J. Rudino-Pinera,E. Alvarez-Sanchez,M.E. 2018. Trichomonas vaginalis metalloproteinase TvMP50 is a monomeric Aminopeptidase P-like enzyme Molecular Biotechnology, 60, 563-575.

Paredes-Amaya,C.C. Valdes-Garcia,G. Juarez-Gonzalez,V.R. Rudino-Pinera,E. Bustamante,V.H. 2018. The Hcp-like protein HilE inhibits homodimerization and DNA binding of the virulence-associated transcriptional regulator HilD in Salmonella Journal of Biological Chemistry, 293, 6578-6592.

Jimenez-Arroyo,N. Gil-Rodriguez,P.C. Diaz-Vilchis,A. Rojas-Trejo,S.P. Rudino-Pinera,E. 2018. Zo-peroxidase: Crystal structure and sequence of a highly-glycosylated peroxidase resistant to high concentrations of H2O2 from Japanese radish Biochemistry and Biophysics Reports, 13, 32-38.

Vega-Garcia,V. Diaz-Vilchis,A. Saucedo-Vazquez,J.P. Solano-Peralta,A. Rudino-Pinera,E. Hansberg,W. 2018. Structure, kinetics, molecular and redox properties of a cytosolic and developmentally regulated fungal catalase-peroxidase Archives of Biochemistry and Biophysics, 640, 17-26.

Garcia,C.F. Pedrini,N. Sanchez-Paz,A. Reyna-Blanco,C.S. Lavarias,S. Muhlia-Almazan,A. Fernandez-Gimenez,A. Laino,A. de-la-Re-Vega,E. Lukaszewicz,G. Lopez-Zavala,A.A. Brieba,L.G. Criscitello,M.F. Carrasco-Miranda,J.S. Garcia-Orozco,K.D. Ochoa-Leyva,A. Rudino-Pinera,E. Sanchez-Flores,A. Sotelo-Mundo,R.R. 2018. De novo assembly and transcriptome characterization of the freshwater prawn Palaemonetes argentinus: Implications for a detoxification response Marine Genomics, 37, 74-81.

Jimenez-Sandoval,P. Vique-Sanchez,J.L. Hidalgo,M.L. Velazquez-Juarez,G. Diaz-Quezada,C. Arroyo-Navarro,L.F. Moran,G.M. Fattori,J. Jessica Diaz-Salazar,A. Rudino-Pinera,E. Sotelo-Mundo,R. Figueira,A.C.M. Lara-Gonzalez,S. Benitez-Cardoza,C.G. Brieba,L.G. 2017. A competent catalytic active site is necessary for substrate induced dimer assembly in triosephosphate isomerase Biochimica et Biophysica Acta (BBA), 1865, 1423-1432.

Campos-Acevedo,A.A. Sotelo-Mundo,R.R. Perez,J. Rudino-Pinera,E. 2017. Is dimerization a common feature in thioredoxins? The case of thioredoxin from Litopenaeus vannamei Acta Crystallographica Section D, 73, 326-339.

Valenzuela-Chavira,I. Contreras-Vergara,C.A. Arvizu-Flores,A.A. Serrano-Posada,H. Lopez-Zavala,A.A. Garcia-Orozco,K.D. Hernandez-Paredes,J. Rudino-Pinera,E. Stojanoff,V. Sotelo-Mundo,R.R. Islas-Osuna,M.A. 2017. Insights into ligand binding to a glutathione S-transferase from mango: Structure, thermodynamics and kinetics Biochimie, 135, 35-45.

Ayala-Sumuano,J.T. Licea-Navarro,A. Rudino-Pinera,E. Rodriguez,E. Rodriguez-Almazan,C. 2017. Sequencing and de novo transcriptome assembly of Anthopleura dowii Verrill (1869), from Mexico Genomics Data, 11, 92-94.

Juarez-Martinez,A.B. Sotelo-Mundo,R.R. Rudino-Pinera,E. 2017. Crystal structure of a class-mu glutathione S-transferase from whiteleg shrimp Litopenaeus vannamei: structural changes in the xenobiotic binding H-site may alter the spectra of molecules bound J Biochem Mol Toxicol, 31, e21838.

Campos-Acevedo,A.A. Diaz-Vilchis,A. Sotelo-Mundo,R.R. Rudino-Pinera,E. 2016. First attempts to crystallize a non-homogeneous sample of thioredoxin from Litopenaeus vannamei: What to do when you have diffraction data of a protein that is not the target? Biochemistry and Biophysics Reports, 8, 284-289.

Venancio-Landeros,A.A. Rudino-Pinera,E. Cardona-Felix,C.S. 2016. Cloning, recombinant production and crystallographic structure of Proliferating Cell Nuclear Antigen from radioresistant archaeon Thermococcus gammatolerans Biochemistry and Biophysics Reports, 8, 200-206.

Lopez-Zavala,A.A. Carrasco-Miranda,J.S. Ramirez-Aguirre,C.D. Lopez-Hidalgo,M. Benitez-Cardoza,C.G. Ochoa-Leyva,A. Cardona-Felix,C.S. Diaz-Quezada,C. Rudino-Pinera,E. Sotelo-Mundo,R.R. Brieba,L.G. 2016. Structural insights from a novel invertebrate triosephosphate isomerase from Litopenaeus vannamei Biochimica et Biophysica Acta (BBA) Proteins and Proteomics, 1864, 1696-1706.

Guerra,Y. Valiente,P.A. Pons,T. Berry,C. Rudino-Pinera,E. 2016. Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop? Journal of Structural Biology, 195, 259-271.

Rudino-Pinera,E. Stojanoff,V. 2016. Editorial: Synchrotron Applications in Life Sciences Protein And Peptide Letters, 23, 200.

Riano-Umbarila,L. Ledezma-Candanoza,L.M. Serrano-Posada,H. Fernandez-Taboada,G. Olamendi-Portugal,T. Rojas-Trejo,S. Gomez-Ramirez,I.V. Rudino-Pinera,E. Possani,L.D. Becerril,B. 2016. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin Journal of Biological Chemistry, 291, 1619-1630.

Serrano-Posada,H. Centeno-Leija,S. Rojas-Trejo,S.P. Rodriguez-Almazan,C. Stojanoff,V. Rudino-Pinera,E. 2015. X-ray-induced catalytic active-site reduction of a multicopper oxidase: structural insights into the proton-relay mechanism and O2-reduction states Acta Crystallographica Section D, 71, 2396-2411.

Serrano-Posada,H. Centeno-Leija,S. Rojas-Trejo,S. Stojanoff,V. Rodriguez-Sanoja,R. Rudino-Pinera,E. Sanchez,S. 2015. Crystallization and X-ray diffraction analysis of a putative bacterial class I labdane-related diterpene synthase Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 71, 1194-1199.

Villalba,M.I. Canul-Tec,J.C. Luna-Martinez,O.D. Sanchez-Alcala,R. Olamendi-Portugal,T. Rudino-Pinera,E. Rojas,S. Sanchez-Lopez,R. Fernandez-Velasco,D.A. Becerril,B. 2015. Site-directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human lambda3r Light Chains Journal of Biological Chemistry, 290, 2577-2592 [Correction vol 290 p 13039].

Campos-Acevedo,A.A. Rudino-Pinera,E. 2014. Crystallographic Studies Evidencing the High Energy Tolerance to Disrupting the Interface Disulfide Bond of Thioredoxin 1 from White Leg Shrimp Litopenaeus vannamei Molecules, 19, 21113-21126.

Lopez-Falcon,B. Meyer-Nava,S. Hernandez-Rodriguez,B. Campos,A. Montero,D. Rudino,E. Vazquez,M. Zurita,M. Valadez-Graham,V. 2014. Characterization of the Drosophila Group Ortholog to the Amino-Terminus of the Alpha-Thalassemia and Mental Retardation X-Linked (ATRX) Vertebrate Protein PLoS ONE, 9, e113182 [correction in 2016 Feb 10;11(2):e0149367].

Ghaffari,N. Sanchez-Flores,A. Doan,R. Garcia-Orozco,K.D. Chen,P.L. Ochoa-Leyva,A. Lopez-Zavala,A.A. Carrasco,J.S. Hong,C. Brieba,L.G. Rudino-Pinera,E. Blood,P.D. Sawyer,J.E. Johnson,C.D. Dindot,S.V. Sotelo-Mundo,R.R. Criscitiello,M.F. 2014. Novel transcriptome assembly and improved annotation of the whiteleg shrimp (Litopenaeus vannamei), a dominant crustacean in global seafood mariculture Scientific Reports, 4, 7081.

Lopez-Zavala,A.A. Quintero-Reyes,I.E. Carrasco-Miranda,J.S. Stojanoff,V. Weichsel,A. Rudino-Pinera,E. Sotelo-Mundo,R.R. 2014. Structure of nucleoside diphosphate kinase from pacific shrimp (Litopenaeus vannamei) in binary complexes with purine and pyrimidine nucleoside diphosphates Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 70, 1150-1154.

Carrasco-Miranda,J.S. Lopez-Zavala,A.A. Arvizu-Flores,A.A. Garcia-Orozco,K.D. Stojanoff,V. Rudino-Pinera,E. Brieba,L.G. Sotelo-Mundo,R.R. 2014. Crystal Structure of the Shrimp Proliferating Cell Nuclear Antigen: Structural Complementarity with WSSV DNA Polymerase PIP-Box PLoS ONE, 9, e94369.

Bello,M. Correa-Basurto,J. Rudino-Pinera,E. 2014. Simulation of the cavity-binding site of three bacterial multicopper oxidases upon complex stabilization: interactional profile and electron transference pathways Journal of Biomolecular Structure and Dynamics, 32, 1303-1317.


Antillon,A. de la Rosa,G. Juarez,A. Moreno,M. Mustre,J. Napsuciale,M. Rudino,E. 2011. First Mexican Synchrotron Radiation Users Meeting Synchrotron Radiation News, 24, 2-5.

de la Mora-Lugo,E. Rudino-Pinera,E. 2008. Cristales, difracción y desplazamientos atómicos: ¿es posible usar datos cristalográficos para extraer movimientos moleculares en proteínas? Mensaje Bioquimico, 32, 135-148.

* Indica publicación con otra institución de adscripción

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